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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3D
All Species:
27.27
Human Site:
S188
Identified Species:
46.15
UniProt:
O15371
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15371
NP_003744.1
548
63973
S188
K
M
R
Y
L
E
V
S
E
P
Q
D
I
E
C
Chimpanzee
Pan troglodytes
XP_001158987
547
63723
S188
K
M
R
Y
L
E
V
S
E
P
Q
D
I
E
C
Rhesus Macaque
Macaca mulatta
XP_001083790
547
63709
S188
K
M
R
Y
L
E
V
S
E
P
Q
D
I
E
C
Dog
Lupus familis
XP_850595
548
63914
S188
K
M
R
Y
L
E
V
S
E
P
Q
D
I
E
C
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Q6AYK8
548
63970
S188
K
M
R
Y
L
E
V
S
E
P
Q
D
I
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506069
668
76273
S188
K
M
R
Y
L
E
V
S
E
P
Q
D
I
E
C
Chicken
Gallus gallus
XP_001234643
699
80199
S342
K
M
R
Y
L
E
V
S
E
P
Q
D
I
E
C
Frog
Xenopus laevis
Q7ZTM9
550
63926
A191
K
M
R
Y
M
E
V
A
D
P
T
D
I
E
C
Zebra Danio
Brachydanio rerio
Q6TH15
552
64071
A191
K
M
R
Y
M
D
V
A
D
P
L
D
I
E
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCK0
560
63779
K194
K
L
S
L
P
N
I
K
E
G
V
D
I
V
T
Honey Bee
Apis mellifera
XP_393057
562
64634
K204
K
L
S
L
P
G
V
K
D
G
E
D
I
L
C
Nematode Worm
Caenorhab. elegans
P30642
570
64271
D208
L
P
N
I
P
G
G
D
D
I
G
D
H
Q
Y
Sea Urchin
Strong. purpuratus
XP_796913
549
63524
V188
N
K
L
R
L
P
T
V
E
D
P
E
D
L
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P56820
591
66706
P212
L
S
Y
T
V
Q
E
P
E
D
L
L
L
C
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.2
99
N.A.
N.A.
98.9
N.A.
73.8
72.5
89.4
90.4
N.A.
56.7
60.5
45.7
63.2
Protein Similarity:
100
99.4
99.4
99.8
N.A.
N.A.
99.8
N.A.
77.4
76.3
96.7
96.7
N.A.
73.3
77
63.5
82.3
P-Site Identity:
100
100
100
100
N.A.
N.A.
100
N.A.
100
100
73.3
66.6
N.A.
26.6
33.3
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
N.A.
100
N.A.
100
100
93.3
93.3
N.A.
40
53.3
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
40.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
57
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
15
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
72
% C
% Asp:
0
0
0
0
0
8
0
8
29
15
0
86
8
0
0
% D
% Glu:
0
0
0
0
0
58
8
0
72
0
8
8
0
65
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
15
8
0
0
15
8
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
8
0
0
8
0
0
8
0
0
79
0
0
% I
% Lys:
79
8
0
0
0
0
0
15
0
0
0
0
0
0
0
% K
% Leu:
15
15
8
15
58
0
0
0
0
0
15
8
8
15
0
% L
% Met:
0
65
0
0
15
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
22
8
0
8
0
65
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
50
0
0
8
0
% Q
% Arg:
0
0
65
8
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
15
0
0
0
0
50
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
8
0
0
8
0
0
0
8
0
0
0
8
% T
% Val:
0
0
0
0
8
0
72
8
0
0
8
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
65
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _