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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPM1D
All Species:
17.88
Human Site:
Y337
Identified Species:
32.78
UniProt:
O15297
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15297
NP_003611.1
605
66675
Y337
Q
D
Q
E
E
K
K
Y
L
M
G
E
H
G
Q
Chimpanzee
Pan troglodytes
XP_511612
605
66629
Y337
Q
D
Q
E
E
K
K
Y
L
M
G
E
H
G
Q
Rhesus Macaque
Macaca mulatta
XP_001110891
605
66558
Y337
Q
D
Q
E
E
K
K
Y
L
M
G
E
H
G
Q
Dog
Lupus familis
XP_852759
729
79555
Y461
Q
D
Q
E
E
K
K
Y
L
M
G
E
H
G
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ67
598
65704
Y330
Q
D
Q
E
E
K
K
Y
L
M
G
E
Q
G
Q
Rat
Rattus norvegicus
P20650
382
42398
V130
D
R
S
G
S
T
A
V
G
V
L
I
S
P
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510733
468
51371
E216
R
A
L
G
R
W
R
E
R
M
L
R
A
D
N
Chicken
Gallus gallus
XP_415890
478
52722
N226
S
C
A
K
M
L
V
N
R
A
L
G
R
W
R
Frog
Xenopus laevis
NP_001085562
554
61512
V300
Q
E
Q
E
R
A
C
V
T
G
D
H
G
Q
T
Zebra Danio
Brachydanio rerio
NP_001007341
534
58704
L282
V
A
R
A
L
G
D
L
W
S
Y
D
F
Y
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_525074
1427
153887
E528
R
K
E
H
L
I
G
E
I
L
N
E
Q
D
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P49596
356
39046
M104
F
L
E
L
D
Q
Q
M
R
V
D
E
E
T
K
Sea Urchin
Strong. purpuratus
XP_787213
568
64302
N297
Y
H
L
L
R
A
D
N
I
S
V
I
C
V
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
78.3
N.A.
88.2
21.4
N.A.
59.6
60.9
59.1
49.4
N.A.
20.7
N.A.
20.6
31.5
Protein Similarity:
100
99.6
98.8
79.9
N.A.
92.7
33.5
N.A.
65.4
66.7
72.5
62.4
N.A.
29.5
N.A.
33.2
49.5
P-Site Identity:
100
100
100
100
N.A.
93.3
6.6
N.A.
6.6
0
20
0
N.A.
6.6
N.A.
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
13.3
N.A.
20
13.3
26.6
13.3
N.A.
33.3
N.A.
46.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
8
8
0
16
8
0
0
8
0
0
8
0
0
% A
% Cys:
0
8
0
0
0
0
8
0
0
0
0
0
8
0
0
% C
% Asp:
8
39
0
0
8
0
16
0
0
0
16
8
0
16
0
% D
% Glu:
0
8
16
47
39
0
0
16
0
0
0
54
8
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% F
% Gly:
0
0
0
16
0
8
8
0
8
8
39
8
8
39
0
% G
% His:
0
8
0
8
0
0
0
0
0
0
0
8
31
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
16
0
0
16
0
0
0
% I
% Lys:
0
8
0
8
0
39
39
0
0
0
0
0
0
0
8
% K
% Leu:
0
8
16
16
16
8
0
8
39
8
24
0
0
0
0
% L
% Met:
0
0
0
0
8
0
0
8
0
47
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
16
0
0
8
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
47
0
47
0
0
8
8
0
0
0
0
0
16
8
47
% Q
% Arg:
16
8
8
0
24
0
8
0
24
0
0
8
8
0
8
% R
% Ser:
8
0
8
0
8
0
0
0
0
16
0
0
8
0
8
% S
% Thr:
0
0
0
0
0
8
0
0
8
0
0
0
0
8
8
% T
% Val:
8
0
0
0
0
0
8
16
0
16
8
0
0
8
8
% V
% Trp:
0
0
0
0
0
8
0
0
8
0
0
0
0
8
0
% W
% Tyr:
8
0
0
0
0
0
0
39
0
0
8
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _