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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPM1D
All Species:
21.52
Human Site:
S559
Identified Species:
39.44
UniProt:
O15297
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15297
NP_003611.1
605
66675
S559
R
N
G
L
S
R
S
S
G
A
Q
P
A
S
L
Chimpanzee
Pan troglodytes
XP_511612
605
66629
S559
R
N
G
L
S
R
S
S
G
A
Q
P
A
S
L
Rhesus Macaque
Macaca mulatta
XP_001110891
605
66558
S559
R
N
G
L
S
R
S
S
G
A
Q
P
A
S
L
Dog
Lupus familis
XP_852759
729
79555
S683
R
N
G
L
T
R
S
S
G
A
Q
P
A
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ67
598
65704
S552
R
N
G
L
S
R
S
S
G
A
Q
A
S
S
L
Rat
Rattus norvegicus
P20650
382
42398
S344
L
A
S
E
N
I
P
S
L
P
P
G
G
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510733
468
51371
K430
L
S
A
T
P
Q
R
K
N
S
V
R
L
T
M
Chicken
Gallus gallus
XP_415890
478
52722
S440
G
V
Q
A
E
G
I
S
T
T
P
Q
R
K
N
Frog
Xenopus laevis
NP_001085562
554
61512
L514
N
S
T
G
Q
T
E
L
P
S
T
T
P
K
R
Zebra Danio
Brachydanio rerio
NP_001007341
534
58704
S496
R
S
P
L
A
P
S
S
S
R
K
R
T
T
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_525074
1427
153887
A917
Y
P
V
T
T
A
T
A
S
E
W
C
A
T
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P49596
356
39046
I318
E
D
G
D
Q
N
Q
I
Q
Q
D
I
S
R
V
Sea Urchin
Strong. purpuratus
XP_787213
568
64302
D514
R
R
R
L
S
L
D
D
S
S
I
S
G
S
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
78.3
N.A.
88.2
21.4
N.A.
59.6
60.9
59.1
49.4
N.A.
20.7
N.A.
20.6
31.5
Protein Similarity:
100
99.6
98.8
79.9
N.A.
92.7
33.5
N.A.
65.4
66.7
72.5
62.4
N.A.
29.5
N.A.
33.2
49.5
P-Site Identity:
100
100
100
93.3
N.A.
86.6
13.3
N.A.
0
6.6
0
26.6
N.A.
13.3
N.A.
6.6
26.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
20
N.A.
33.3
6.6
13.3
53.3
N.A.
40
N.A.
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
8
8
0
8
0
39
0
8
39
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
8
0
8
0
0
8
8
0
0
8
0
0
0
8
% D
% Glu:
8
0
0
8
8
0
8
0
0
8
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
47
8
0
8
0
0
39
0
0
8
16
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
8
8
0
0
8
8
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
8
0
0
16
0
% K
% Leu:
16
0
0
54
0
8
0
8
8
0
0
0
8
0
54
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
8
39
0
0
8
8
0
0
8
0
0
0
0
0
8
% N
% Pro:
0
8
8
0
8
8
8
0
8
8
16
31
8
0
0
% P
% Gln:
0
0
8
0
16
8
8
0
8
8
39
8
0
0
0
% Q
% Arg:
54
8
8
0
0
39
8
0
0
8
0
16
8
8
16
% R
% Ser:
0
24
8
0
39
0
47
62
24
24
0
8
16
47
0
% S
% Thr:
0
0
8
16
16
8
8
0
8
8
8
8
8
24
0
% T
% Val:
0
8
8
0
0
0
0
0
0
0
8
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _