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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPM1D
All Species:
22.12
Human Site:
S543
Identified Species:
40.56
UniProt:
O15297
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15297
NP_003611.1
605
66675
S543
R
T
L
E
E
S
N
S
G
P
L
M
K
K
H
Chimpanzee
Pan troglodytes
XP_511612
605
66629
S543
R
T
L
E
E
S
N
S
G
P
L
M
K
K
H
Rhesus Macaque
Macaca mulatta
XP_001110891
605
66558
S543
R
T
L
E
E
S
N
S
G
P
L
M
K
K
H
Dog
Lupus familis
XP_852759
729
79555
S667
R
T
L
E
E
S
N
S
G
P
L
M
K
K
H
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ67
598
65704
S536
R
T
L
K
E
S
N
S
G
P
L
M
K
K
H
Rat
Rattus norvegicus
P20650
382
42398
P328
K
K
Q
G
E
G
V
P
D
L
V
H
V
M
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510733
468
51371
R414
P
R
R
G
G
P
T
R
S
G
G
A
Q
R
E
Chicken
Gallus gallus
XP_415890
478
52722
P424
S
G
P
A
V
K
K
P
R
R
G
L
S
R
S
Frog
Xenopus laevis
NP_001085562
554
61512
K498
S
N
S
A
P
A
V
K
K
L
K
R
N
F
P
Zebra Danio
Brachydanio rerio
NP_001007341
534
58704
S480
R
T
P
D
T
P
L
S
S
P
V
A
K
R
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_525074
1427
153887
S901
Q
M
E
V
E
A
I
S
S
S
G
Q
H
E
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P49596
356
39046
P302
L
F
T
K
C
A
R
P
A
V
F
T
G
V
N
Sea Urchin
Strong. purpuratus
XP_787213
568
64302
K498
N
A
L
S
A
P
A
K
G
S
S
S
R
Q
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
78.3
N.A.
88.2
21.4
N.A.
59.6
60.9
59.1
49.4
N.A.
20.7
N.A.
20.6
31.5
Protein Similarity:
100
99.6
98.8
79.9
N.A.
92.7
33.5
N.A.
65.4
66.7
72.5
62.4
N.A.
29.5
N.A.
33.2
49.5
P-Site Identity:
100
100
100
100
N.A.
93.3
6.6
N.A.
0
0
0
33.3
N.A.
13.3
N.A.
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
13.3
13.3
6.6
53.3
N.A.
33.3
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
16
8
24
8
0
8
0
0
16
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
8
31
54
0
0
0
0
0
0
0
0
8
8
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
8
0
0
8
8
% F
% Gly:
0
8
0
16
8
8
0
0
47
8
24
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
39
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
8
8
0
16
0
8
8
16
8
0
8
0
47
39
0
% K
% Leu:
8
0
47
0
0
0
8
0
0
16
39
8
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
39
0
8
0
% M
% Asn:
8
8
0
0
0
0
39
0
0
0
0
0
8
0
8
% N
% Pro:
8
0
16
0
8
24
0
24
0
47
0
0
0
0
16
% P
% Gln:
8
0
8
0
0
0
0
0
0
0
0
8
8
8
0
% Q
% Arg:
47
8
8
0
0
0
8
8
8
8
0
8
8
24
8
% R
% Ser:
16
0
8
8
0
39
0
54
24
16
8
8
8
0
16
% S
% Thr:
0
47
8
0
8
0
8
0
0
0
0
8
0
0
0
% T
% Val:
0
0
0
8
8
0
16
0
0
8
16
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _