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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPM1D
All Species:
19.39
Human Site:
S421
Identified Species:
35.56
UniProt:
O15297
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15297
NP_003611.1
605
66675
S421
C
S
T
P
P
V
K
S
L
E
E
D
P
W
P
Chimpanzee
Pan troglodytes
XP_511612
605
66629
S421
C
S
T
P
P
V
K
S
L
E
E
D
P
W
P
Rhesus Macaque
Macaca mulatta
XP_001110891
605
66558
S421
C
S
T
P
P
V
K
S
L
E
E
D
P
W
P
Dog
Lupus familis
XP_852759
729
79555
S545
C
S
T
P
P
V
K
S
L
E
E
D
P
W
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ67
598
65704
S414
S
S
T
P
P
I
K
S
P
E
E
D
A
W
P
Rat
Rattus norvegicus
P20650
382
42398
H206
D
F
D
Y
K
C
V
H
G
K
G
P
T
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510733
468
51371
L292
R
L
S
S
K
D
H
L
P
A
L
V
R
S
G
Chicken
Gallus gallus
XP_415890
478
52722
P302
L
L
E
D
D
P
W
P
R
L
N
A
S
E
P
Frog
Xenopus laevis
NP_001085562
554
61512
S376
H
L
S
S
T
P
C
S
T
P
P
I
K
F
L
Zebra Danio
Brachydanio rerio
NP_001007341
534
58704
R358
L
G
C
H
A
L
M
R
W
R
Q
R
M
L
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_525074
1427
153887
L779
A
E
S
Y
N
S
L
L
N
E
Q
E
E
Q
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P49596
356
39046
N180
E
F
N
R
V
N
G
N
L
A
L
S
R
A
L
Sea Urchin
Strong. purpuratus
XP_787213
568
64302
S376
Y
N
R
L
Y
C
M
S
N
K
E
R
R
Q
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
78.3
N.A.
88.2
21.4
N.A.
59.6
60.9
59.1
49.4
N.A.
20.7
N.A.
20.6
31.5
Protein Similarity:
100
99.6
98.8
79.9
N.A.
92.7
33.5
N.A.
65.4
66.7
72.5
62.4
N.A.
29.5
N.A.
33.2
49.5
P-Site Identity:
100
100
100
100
N.A.
73.3
0
N.A.
0
6.6
6.6
0
N.A.
6.6
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
80
6.6
N.A.
6.6
6.6
20
13.3
N.A.
26.6
N.A.
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
0
16
0
8
8
8
0
% A
% Cys:
31
0
8
0
0
16
8
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
8
8
8
0
0
0
0
0
39
0
0
0
% D
% Glu:
8
8
8
0
0
0
0
0
0
47
47
8
8
16
8
% E
% Phe:
0
16
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
8
0
0
0
0
8
0
8
0
8
0
0
0
8
% G
% His:
8
0
0
8
0
0
8
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
0
0
16
0
39
0
0
16
0
0
8
0
0
% K
% Leu:
16
24
0
8
0
8
8
16
39
8
16
0
0
8
16
% L
% Met:
0
0
0
0
0
0
16
0
0
0
0
0
8
0
0
% M
% Asn:
0
8
8
0
8
8
0
8
16
0
8
0
0
0
0
% N
% Pro:
0
0
0
39
39
16
0
8
16
8
8
8
31
0
47
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
16
0
0
16
8
% Q
% Arg:
8
0
8
8
0
0
0
8
8
8
0
16
24
0
8
% R
% Ser:
8
39
24
16
0
8
0
54
0
0
0
8
8
8
0
% S
% Thr:
0
0
39
0
8
0
0
0
8
0
0
0
8
0
0
% T
% Val:
0
0
0
0
8
31
8
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
8
0
8
0
0
0
0
39
0
% W
% Tyr:
8
0
0
16
8
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _