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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CASC3
All Species:
10
Human Site:
T441
Identified Species:
27.5
UniProt:
O15234
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15234
NP_031385.2
703
76278
T441
A
P
P
V
P
E
T
T
P
T
P
P
T
K
T
Chimpanzee
Pan troglodytes
XP_511470
633
69498
A397
S
G
L
E
Q
D
V
A
Q
L
N
I
A
E
Q
Rhesus Macaque
Macaca mulatta
XP_001096548
704
76487
T442
A
P
P
V
P
E
T
T
P
T
P
P
T
K
T
Dog
Lupus familis
XP_537649
703
76251
T441
A
P
P
V
P
E
T
T
P
P
P
P
A
K
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8K3W3
698
75752
E436
A
S
T
A
T
V
P
E
T
T
P
A
A
K
T
Rat
Rattus norvegicus
Q8K3X0
699
75886
S437
S
A
A
T
V
P
E
S
T
P
P
A
A
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_423806
573
63459
R353
R
A
E
Q
S
P
P
R
D
K
S
P
E
V
E
Frog
Xenopus laevis
A0JMU8
686
76943
P424
A
V
A
A
E
F
T
P
A
P
L
N
V
K
Q
Zebra Danio
Brachydanio rerio
Q1ECZ4
754
82725
A491
A
V
Q
Q
A
P
V
A
A
K
S
E
S
W
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.7
97.5
95.4
N.A.
90.3
91.6
N.A.
N.A.
55.3
56.6
45.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
89.7
98.1
96.3
N.A.
93
94
N.A.
N.A.
62.4
69.9
57.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
86.6
N.A.
33.3
20
N.A.
N.A.
6.6
20
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
100
86.6
N.A.
33.3
33.3
N.A.
N.A.
6.6
20
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
67
23
23
23
12
0
0
23
23
0
0
23
45
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
12
0
0
12
0
0
0
0
0
0
% D
% Glu:
0
0
12
12
12
34
12
12
0
0
0
12
12
12
12
% E
% Phe:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
23
0
0
0
67
0
% K
% Leu:
0
0
12
0
0
0
0
0
0
12
12
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
12
12
0
0
0
% N
% Pro:
0
34
34
0
34
34
23
12
34
34
56
45
0
0
0
% P
% Gln:
0
0
12
23
12
0
0
0
12
0
0
0
0
0
34
% Q
% Arg:
12
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% R
% Ser:
23
12
0
0
12
0
0
12
0
0
23
0
12
0
0
% S
% Thr:
0
0
12
12
12
0
45
34
23
34
0
0
23
0
56
% T
% Val:
0
23
0
34
12
12
23
0
0
0
0
0
12
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _