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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PEX12 All Species: 20.3
Human Site: S292 Identified Species: 29.78
UniProt: O00623 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00623 NP_000277.1 359 40797 S292 P V H L D Y N S D S P L L P K
Chimpanzee Pan troglodytes XP_001174172 359 40821 S292 P V H L D Y N S D S P L L P K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_548259 359 40831 S292 P V H L D Y N S D S P L L P K
Cat Felis silvestris
Mouse Mus musculus Q8VC48 359 40614 S292 P V H L D Y N S D S P L L P K
Rat Rattus norvegicus O88177 359 40663 S292 P V H L D Y N S D S P L L P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511496 312 33803 F246 V F L P L V P F P E R R L C P
Chicken Gallus gallus XP_415773 356 39947 V289 P V H L D H G V D S A L L P K
Frog Xenopus laevis NP_001086511 353 40718 Y287 I H F D L E T Y S P L L P K L
Zebra Danio Brachydanio rerio NP_956499 303 34092 V237 V S A A V G G V A V S L S T S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VPT5 297 34525 P231 A M P R K Q L P K E V Q Q S L
Honey Bee Apis mellifera XP_624974 285 32991 P219 S L P I P S P P K I P E I A K
Nematode Worm Caenorhab. elegans Q19189 359 41271 K291 A I P S P P H K M I I S E S E
Sea Urchin Strong. purpuratus XP_788130 354 40571 Y287 P K E R E P E Y C Q I L L P R
Poplar Tree Populus trichocarpa XP_002325774 388 43941 K322 P P A P K V A K E G I P L P P
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M841 393 44382 K327 P P A P K M A K E G I P L P P
Baker's Yeast Sacchar. cerevisiae Q04370 399 45974 D322 P P F S S H S D K T E D K E G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 N.A. 92.1 N.A. 89.4 88.5 N.A. 46.7 76 64 51.5 N.A. 29.8 31.7 35.9 45.6
Protein Similarity: 100 99.7 N.A. 96 N.A. 93.3 92.7 N.A. 57.3 85.7 79.6 65.4 N.A. 47 49 56.2 68.5
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 6.6 73.3 6.6 6.6 N.A. 0 13.3 0 26.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 6.6 80 6.6 6.6 N.A. 6.6 33.3 20 40
Percent
Protein Identity: 31.9 N.A. N.A. 31.3 22.3 N.A.
Protein Similarity: 48.7 N.A. N.A. 48.3 40.3 N.A.
P-Site Identity: 20 N.A. N.A. 20 6.6 N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 0 19 7 0 0 13 0 7 0 7 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 7 0 0 0 0 7 0 % C
% Asp: 0 0 0 7 38 0 0 7 38 0 0 7 0 0 0 % D
% Glu: 0 0 7 0 7 7 7 0 13 13 7 7 7 7 7 % E
% Phe: 0 7 13 0 0 0 0 7 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 7 13 0 0 13 0 0 0 0 7 % G
% His: 0 7 38 0 0 13 7 0 0 0 0 0 0 0 0 % H
% Ile: 7 7 0 7 0 0 0 0 0 13 25 0 7 0 0 % I
% Lys: 0 7 0 0 19 0 0 19 19 0 0 0 7 7 44 % K
% Leu: 0 7 7 38 13 0 7 0 0 0 7 57 63 0 13 % L
% Met: 0 7 0 0 0 7 0 0 7 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 32 0 0 0 0 0 0 0 0 % N
% Pro: 63 19 19 19 13 13 13 13 7 7 38 13 7 57 19 % P
% Gln: 0 0 0 0 0 7 0 0 0 7 0 7 7 0 0 % Q
% Arg: 0 0 0 13 0 0 0 0 0 0 7 7 0 0 7 % R
% Ser: 7 7 0 13 7 7 7 32 7 38 7 7 7 13 7 % S
% Thr: 0 0 0 0 0 0 7 0 0 7 0 0 0 7 0 % T
% Val: 13 38 0 0 7 13 0 13 0 7 7 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 32 0 13 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _