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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLDN5 All Species: 30
Human Site: Y148 Identified Species: 73.33
UniProt: O00501 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00501 NP_001124333.1 218 23147 Y148 N I V V R E F Y D P S V P V S
Chimpanzee Pan troglodytes XP_530408 219 23200 Y148 N I V V R E F Y D P S V P V S
Rhesus Macaque Macaca mulatta XP_001104943 218 23049 Y148 N I V V R E F Y D P S V P V S
Dog Lupus familis XP_543546 302 32016 Y232 N I V V R E F Y D P T V P M S
Cat Felis silvestris
Mouse Mus musculus O54942 218 23036 Y148 N I V V R E F Y D P T V P V S
Rat Rattus norvegicus Q9JKD6 218 23054 Y148 N I V V R E F Y D P T V P V S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511784 216 22376 H148 H T V I S D F H N P R V P V S
Chicken Gallus gallus NP_989532 216 23162 Y148 N I V I S D F Y D P S V P P S
Frog Xenopus laevis NP_001085820 216 22996 Y148 N I I I T E F Y D P R V P A P
Zebra Danio Brachydanio rerio Q9YH91 208 22187 A140 L I P V C W S A N S V I K D F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 98.1 67.5 N.A. 91.7 91.2 N.A. 70.6 70.1 62.3 51.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.5 98.1 68.8 N.A. 94 93.5 N.A. 82.5 82.5 77 71.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. 46.6 73.3 60 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 80 86.6 73.3 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 10 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 20 0 0 80 0 0 0 0 10 0 % D
% Glu: 0 0 0 0 0 70 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 90 0 0 0 0 0 0 0 10 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 10 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % H
% Ile: 0 90 10 30 0 0 0 0 0 0 0 10 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % K
% Leu: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 80 0 0 0 0 0 0 0 20 0 0 0 0 0 0 % N
% Pro: 0 0 10 0 0 0 0 0 0 90 0 0 90 10 10 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 60 0 0 0 0 0 20 0 0 0 0 % R
% Ser: 0 0 0 0 20 0 10 0 0 10 40 0 0 0 80 % S
% Thr: 0 10 0 0 10 0 0 0 0 0 30 0 0 0 0 % T
% Val: 0 0 80 70 0 0 0 0 0 0 10 90 0 60 0 % V
% Trp: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 80 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _