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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIK3C2A All Species: 14.24
Human Site: Y73 Identified Species: 34.81
UniProt: O00443 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00443 NP_002636.2 1686 190680 Y73 Q V Y N K Q D Y D L M V F P E
Chimpanzee Pan troglodytes XP_001172532 1686 190756 Y73 Q V Y N K Q D Y D L M V F P E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542517 1688 190811 Y72 Q V Y N K Q D Y D L M V F P E
Cat Felis silvestris
Mouse Mus musculus Q61194 1686 190739 Y73 Q G F N K Q D Y D L M V F P E
Rat Rattus norvegicus O70173 1505 170957
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510027 1689 189289 H73 Q V Q S Q E E H D L M V F P E
Chicken Gallus gallus XP_421003 1693 190736 F78 Q D H D L M V F P E S D A K R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_700029 1738 195284 N63 S S V N P L P N P T A Q T S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524028 1876 210456 Y165 T A A Q P T P Y G M V A G G V
Honey Bee Apis mellifera XP_396869 1681 191083 Q70 N I Q F E K F Q C R S R P R P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 N.A. 93.5 N.A. 90.2 31.1 N.A. 83.3 75.4 N.A. 60.2 N.A. 32.5 33.9 N.A. N.A.
Protein Similarity: 100 99.6 N.A. 96.8 N.A. 94.5 50.6 N.A. 90.2 85.4 N.A. 75.3 N.A. 51 54.7 N.A. N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 86.6 0 N.A. 60 6.6 N.A. 6.6 N.A. 6.6 0 N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 93.3 0 N.A. 93.3 26.6 N.A. 6.6 N.A. 20 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 10 0 0 0 0 0 0 0 10 10 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % C
% Asp: 0 10 0 10 0 0 40 0 50 0 0 10 0 0 0 % D
% Glu: 0 0 0 0 10 10 10 0 0 10 0 0 0 0 50 % E
% Phe: 0 0 10 10 0 0 10 10 0 0 0 0 50 0 0 % F
% Gly: 0 10 0 0 0 0 0 0 10 0 0 0 10 10 0 % G
% His: 0 0 10 0 0 0 0 10 0 0 0 0 0 0 0 % H
% Ile: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 40 10 0 0 0 0 0 0 0 10 0 % K
% Leu: 0 0 0 0 10 10 0 0 0 50 0 0 0 0 0 % L
% Met: 0 0 0 0 0 10 0 0 0 10 50 0 0 0 0 % M
% Asn: 10 0 0 50 0 0 0 10 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 20 0 20 0 20 0 0 0 10 50 10 % P
% Gln: 60 0 20 10 10 40 0 10 0 0 0 10 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 10 0 10 0 10 10 % R
% Ser: 10 10 0 10 0 0 0 0 0 0 20 0 0 10 10 % S
% Thr: 10 0 0 0 0 10 0 0 0 10 0 0 10 0 0 % T
% Val: 0 40 10 0 0 0 10 0 0 0 10 50 0 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 30 0 0 0 0 50 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _