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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SAP18 All Species: 31.52
Human Site: Y77 Identified Species: 53.33
UniProt: O00422 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00422 NP_005861.2 153 17561 Y77 T S L V K E V Y P E A R K K G
Chimpanzee Pan troglodytes XP_509567 153 17527 Y77 T S L V K E V Y P E A R K K G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_534536 172 19536 Y96 T S L V K E V Y P E A R K K G
Cat Felis silvestris
Mouse Mus musculus O55128 153 17577 Y77 T S L V K E V Y P E A R K K G
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516469 153 17557 Y77 T S L V K E V Y P E A R K K G
Chicken Gallus gallus NP_989643 153 17587 Y77 T S L V K E V Y P E A R K K G
Frog Xenopus laevis NP_001089273 153 17596 Y77 T S L V K E V Y S D A R K K G
Zebra Danio Brachydanio rerio NP_957014 153 17506 Y77 T S L V K E V Y P E A R K K G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VEX9 150 17269 P75 S L V R D V N P D T R K K G T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09250 166 18953 N77 T S L I K E V N P D A R R K G
Sea Urchin Strong. purpuratus XP_784248 183 19677 P80 S L V K E V N P D A R R R G T
Poplar Tree Populus trichocarpa XP_002302551 151 17102 K75 E V Q I Y T W K D A T L R E L
Maize Zea mays NP_001132841 152 17110 W75 D E V Q I Y T W K D A T L R E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O64644 152 17146 D76 V Q I Y T W K D A S L R E L T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 N.A. 88.3 N.A. 98 N.A. N.A. 99.3 98.6 92.8 90.1 N.A. 58.8 N.A. 46.9 55.1
Protein Similarity: 100 99.3 N.A. 88.3 N.A. 98.6 N.A. N.A. 100 99.3 96 93.4 N.A. 76.4 N.A. 66.8 66.1
P-Site Identity: 100 100 N.A. 100 N.A. 100 N.A. N.A. 100 100 86.6 100 N.A. 6.6 N.A. 73.3 6.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 N.A. N.A. 100 100 93.3 100 N.A. 26.6 N.A. 93.3 33.3
Percent
Protein Identity: 48.3 47.7 N.A. 47 N.A. N.A.
Protein Similarity: 60.7 62 N.A. 62.7 N.A. N.A.
P-Site Identity: 0 6.6 N.A. 6.6 N.A. N.A.
P-Site Similarity: 20 33.3 N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 8 15 72 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 8 0 0 8 22 22 0 0 0 0 0 % D
% Glu: 8 8 0 0 8 65 0 0 0 50 0 0 8 8 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 15 65 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 15 8 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 8 65 0 8 8 8 0 0 8 65 65 0 % K
% Leu: 0 15 65 0 0 0 0 0 0 0 8 8 8 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 15 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 15 58 0 0 0 0 0 0 % P
% Gln: 0 8 8 8 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 8 0 0 0 0 0 0 15 79 22 8 0 % R
% Ser: 15 65 0 0 0 0 0 0 8 8 0 0 0 0 0 % S
% Thr: 65 0 0 0 8 8 8 0 0 8 8 8 0 0 22 % T
% Val: 8 8 22 58 0 15 65 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 8 8 8 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 8 8 0 58 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _