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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE2A
All Species:
23.94
Human Site:
Y680
Identified Species:
52.67
UniProt:
O00408
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00408
NP_001137311.1
941
105717
Y680
K
N
L
E
L
T
N
Y
L
E
D
I
E
I
F
Chimpanzee
Pan troglodytes
XP_001174746
941
105685
Y680
K
T
L
E
L
T
N
Y
L
E
D
I
E
I
F
Rhesus Macaque
Macaca mulatta
NP_001124298
941
105556
Y680
K
N
L
E
L
T
N
Y
L
E
D
I
E
I
F
Dog
Lupus familis
XP_851951
935
104266
Y674
K
N
L
E
L
T
N
Y
L
E
D
I
E
I
F
Cat
Felis silvestris
Mouse
Mus musculus
Q922S4
916
103270
Y656
K
N
L
E
L
S
N
Y
L
E
D
I
E
I
F
Rat
Rattus norvegicus
Q01062
928
104646
Y668
K
N
L
E
L
S
N
Y
L
E
D
I
E
I
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002664806
315
36239
D70
G
R
A
A
A
G
S
D
L
S
D
E
R
D
G
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
T642
T
T
A
G
F
Q
E
T
L
T
D
V
E
I
L
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
I884
T
T
T
Q
W
W
K
I
F
G
E
I
E
C
L
Honey Bee
Apis mellifera
XP_396028
715
83070
D470
S
C
L
C
H
D
I
D
H
R
G
T
N
N
M
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798824
255
29890
N10
M
C
M
F
D
D
M
N
M
I
N
R
W
R
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
97.9
92.6
N.A.
90.1
90.7
N.A.
N.A.
N.A.
N.A.
26.6
24
21.9
36.8
N.A.
20.4
Protein Similarity:
100
99.8
98.8
95.2
N.A.
93
93.9
N.A.
N.A.
N.A.
N.A.
29.6
43
36.3
53
N.A.
24.1
P-Site Identity:
100
93.3
100
100
N.A.
93.3
93.3
N.A.
N.A.
N.A.
N.A.
13.3
26.6
13.3
6.6
N.A.
0
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
N.A.
N.A.
N.A.
N.A.
20
33.3
26.6
6.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
19
10
10
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
19
0
10
0
0
0
0
0
0
0
0
0
10
0
% C
% Asp:
0
0
0
0
10
19
0
19
0
0
73
0
0
10
0
% D
% Glu:
0
0
0
55
0
0
10
0
0
55
10
10
73
0
0
% E
% Phe:
0
0
0
10
10
0
0
0
10
0
0
0
0
0
55
% F
% Gly:
10
0
0
10
0
10
0
0
0
10
10
0
0
0
10
% G
% His:
0
0
0
0
10
0
0
0
10
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
10
10
0
10
0
64
0
64
10
% I
% Lys:
55
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
64
0
55
0
0
0
73
0
0
0
0
0
19
% L
% Met:
10
0
10
0
0
0
10
0
10
0
0
0
0
0
10
% M
% Asn:
0
46
0
0
0
0
55
10
0
0
10
0
10
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
0
0
0
0
0
0
0
10
0
10
10
10
0
% R
% Ser:
10
0
0
0
0
19
10
0
0
10
0
0
0
0
0
% S
% Thr:
19
28
10
0
0
37
0
10
0
10
0
10
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
10
10
0
0
0
0
0
0
10
0
0
% W
% Tyr:
0
0
0
0
0
0
0
55
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _