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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AP4M1 All Species: 22.42
Human Site: S78 Identified Species: 37.95
UniProt: O00189 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00189 NP_004713.2 453 49977 S78 S E N V S P F S L L E L L S R
Chimpanzee Pan troglodytes XP_001145485 453 49942 S78 S E N V S P F S L L E L L S R
Rhesus Macaque Macaca mulatta XP_001101970 453 49960 S78 S E N V S P F S L L E L L S R
Dog Lupus familis XP_546965 452 49876 S78 S E N I S P F S L L E L L S R
Cat Felis silvestris
Mouse Mus musculus Q9JKC7 449 49491 S78 L E N V S P F S L L E L L S R
Rat Rattus norvegicus Q2PWT8 453 49834 S78 S E N V S P F S L L E L L S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZMP6 433 49371 M77 K Q N V N A A M V F E F L Y K
Frog Xenopus laevis Q801Q8 435 49666 M77 K Q N V N A A M V F E F L Y K
Zebra Danio Brachydanio rerio Q7ZW98 436 49724 M77 K Q N V N A A M V F E F L Y K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P35603 441 50282 M77 R Q N V N A A M V F E F L K R
Sea Urchin Strong. purpuratus XP_782338 436 48883 A78 S Q D E P P F A A L E L L E R
Poplar Tree Populus trichocarpa XP_002302340 446 50253 L80 R A N V S P S L V L E L L Q R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_194186 451 50928 L81 R V N V S P S L V L E L L Q R
Baker's Yeast Sacchar. cerevisiae Q00776 475 53855 A80 S L S A N A A A I F T F L H K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.1 94.6 N.A. 92.9 92.9 N.A. N.A. 29.1 29.1 29.3 N.A. N.A. N.A. 27.5 39
Protein Similarity: 100 99.7 99.1 96.2 N.A. 95.1 95.1 N.A. N.A. 50.9 50.7 50.9 N.A. N.A. N.A. 49.2 58.5
P-Site Identity: 100 100 100 93.3 N.A. 93.3 100 N.A. N.A. 26.6 26.6 26.6 N.A. N.A. N.A. 33.3 53.3
P-Site Similarity: 100 100 100 100 N.A. 93.3 100 N.A. N.A. 53.3 53.3 53.3 N.A. N.A. N.A. 53.3 73.3
Percent
Protein Identity: 35.3 N.A. N.A. 35.3 24.8 N.A.
Protein Similarity: 60.9 N.A. N.A. 60 46.9 N.A.
P-Site Identity: 60 N.A. N.A. 60 13.3 N.A.
P-Site Similarity: 66.6 N.A. N.A. 66.6 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 8 0 36 36 15 8 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 43 0 8 0 0 0 0 0 0 93 0 0 8 0 % E
% Phe: 0 0 0 0 0 0 50 0 0 36 0 36 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 8 0 0 0 0 8 0 0 0 0 0 0 % I
% Lys: 22 0 0 0 0 0 0 0 0 0 0 0 0 8 29 % K
% Leu: 8 8 0 0 0 0 0 15 43 65 0 65 100 0 0 % L
% Met: 0 0 0 0 0 0 0 29 0 0 0 0 0 0 0 % M
% Asn: 0 0 86 0 36 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 65 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 36 0 0 0 0 0 0 0 0 0 0 0 15 0 % Q
% Arg: 22 0 0 0 0 0 0 0 0 0 0 0 0 0 72 % R
% Ser: 50 0 8 0 58 0 15 43 0 0 0 0 0 43 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % T
% Val: 0 8 0 79 0 0 0 0 43 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 22 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _