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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: STXBP3 All Species: 19.09
Human Site: Y219 Identified Species: 32.31
UniProt: O00186 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00186 NP_009200.2 592 67764 Y219 E K K L E D Y Y K I D E K S L
Chimpanzee Pan troglodytes XP_001145368 592 67778 Y219 E K K L E D Y Y K I D E K S L
Rhesus Macaque Macaca mulatta XP_001087621 798 89892 Y425 E K K L E N Y Y K I D E K S L
Dog Lupus familis XP_547249 592 67727 Y219 E K K L E N Y Y K I D E K S Q
Cat Felis silvestris
Mouse Mus musculus Q60770 592 67924 Y219 E K K L E D Y Y K I D E K G L
Rat Rattus norvegicus P61765 594 67550 A214 D K L D A Y K A D D P T M G E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508183 589 67400 S227 D R G F D P S S P V L H E L T
Chicken Gallus gallus Q6R748 594 67454 A214 D K L D A Y K A D D P T M G E
Frog Xenopus laevis NP_001090087 589 67497 M218 Q L V Q Y Y R M D E K D Q F K
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07327 597 67832 A225 Q K L D A Y K A D D A T M G E
Honey Bee Apis mellifera XP_396375 585 66573 A214 Q K L D A Y K A D E P T M G E
Nematode Worm Caenorhab. elegans P34815 673 76715 A294 Q K L D A Y K A D D P S M G E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SZ77 662 75299 A230 E L I P T K L A A S V W N C L
Baker's Yeast Sacchar. cerevisiae P30619 724 83462 F235 Y A R N N P D F P P Q N T E R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 73 94.7 N.A. 91.8 51.3 N.A. 49.6 51.5 67.5 N.A. N.A. 43.2 44.9 39.6 N.A.
Protein Similarity: 100 100 73.9 96.9 N.A. 96.1 74 N.A. 72.1 73.9 82.7 N.A. N.A. 67 68.9 60.7 N.A.
P-Site Identity: 100 100 93.3 86.6 N.A. 93.3 6.6 N.A. 0 6.6 0 N.A. N.A. 6.6 6.6 6.6 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 13.3 N.A. 33.3 13.3 20 N.A. N.A. 13.3 13.3 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27.3 22.5 N.A.
Protein Similarity: N.A. N.A. N.A. 49.4 42.2 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 36 0 0 43 8 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 22 0 0 36 8 22 8 0 43 29 36 8 0 0 0 % D
% Glu: 43 0 0 0 36 0 0 0 0 15 0 36 8 8 36 % E
% Phe: 0 0 0 8 0 0 0 8 0 0 0 0 0 8 0 % F
% Gly: 0 0 8 0 0 0 0 0 0 0 0 0 0 43 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 36 0 0 0 0 0 % I
% Lys: 0 72 36 0 0 8 36 0 36 0 8 0 36 0 8 % K
% Leu: 0 15 36 36 0 0 8 0 0 0 8 0 0 8 36 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 0 36 0 0 % M
% Asn: 0 0 0 8 8 15 0 0 0 0 0 8 8 0 0 % N
% Pro: 0 0 0 8 0 15 0 0 15 8 29 0 0 0 0 % P
% Gln: 29 0 0 8 0 0 0 0 0 0 8 0 8 0 8 % Q
% Arg: 0 8 8 0 0 0 8 0 0 0 0 0 0 0 8 % R
% Ser: 0 0 0 0 0 0 8 8 0 8 0 8 0 29 0 % S
% Thr: 0 0 0 0 8 0 0 0 0 0 0 29 8 0 8 % T
% Val: 0 0 8 0 0 0 0 0 0 8 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % W
% Tyr: 8 0 0 0 8 43 36 36 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _