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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DDX39 All Species: 52.12
Human Site: S40 Identified Species: 76.44
UniProt: O00148 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00148 NP_005795.2 427 49130 S40 D I K G S Y V S I H S S G F R
Chimpanzee Pan troglodytes XP_001171771 416 46980 S40 D I K G S Y V S I H S S G F R
Rhesus Macaque Macaca mulatta XP_001112060 544 61883 S168 D I K G S Y V S I H S S G F R
Dog Lupus familis XP_533895 427 49073 S40 D V K G S Y V S I H S S G F R
Cat Felis silvestris
Mouse Mus musculus Q8VDW0 427 49049 S40 D V K G S Y V S I H S S G F R
Rat Rattus norvegicus Q5U216 427 49091 S40 D V K G S Y V S I H S S G F R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515366 430 49724 A40 S V K G S Y V A I H S S G F R
Chicken Gallus gallus Q5ZHZ0 428 48985 S41 D V K G S Y V S I H S S G F R
Frog Xenopus laevis NP_001079623 427 49158 S40 E V K G S Y V S I H S S G F R
Zebra Danio Brachydanio rerio NP_998142 427 48929 S40 E V K G S Y V S I H S S G F R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q27268 424 48633 S37 D V K G T Y V S I H S S G F R
Honey Bee Apis mellifera XP_624894 424 48776 S38 E V K G T Y V S I H S S G F R
Nematode Worm Caenorhab. elegans Q18212 425 48474 S37 K T K G T Y A S I H S S G F R
Sea Urchin Strong. purpuratus XP_779919 429 49042 S43 T K A K G Y V S I H S S G F R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LFN6 427 48319 G42 A V K K G Y V G I H S S G F R
Baker's Yeast Sacchar. cerevisiae Q07478 446 50290 G58 D K K G S Y V G I H S T G F K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.9 76.2 97.8 N.A. 97.1 96.7 N.A. 76.5 89.9 90.4 91.8 N.A. 82.1 82.4 75.8 82.2
Protein Similarity: 100 89.9 76.4 99.5 N.A. 99.7 99.5 N.A. 89.5 96.7 96.4 97.1 N.A. 91.8 91.5 87.5 90.9
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 80 93.3 86.6 86.6 N.A. 86.6 80 73.3 66.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 100 100 100 N.A. 100 100 80 66.6
Percent
Protein Identity: N.A. N.A. N.A. 70.4 62.1 N.A.
Protein Similarity: N.A. N.A. N.A. 84.3 78 N.A.
P-Site Identity: N.A. N.A. N.A. 66.6 73.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 73.3 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 7 0 0 0 7 7 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 57 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 100 0 % F
% Gly: 0 0 0 88 13 0 0 13 0 0 0 0 100 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 % H
% Ile: 0 19 0 0 0 0 0 0 100 0 0 0 0 0 0 % I
% Lys: 7 13 94 13 0 0 0 0 0 0 0 0 0 0 7 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 94 % R
% Ser: 7 0 0 0 69 0 0 82 0 0 100 94 0 0 0 % S
% Thr: 7 7 0 0 19 0 0 0 0 0 0 7 0 0 0 % T
% Val: 0 63 0 0 0 0 94 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 100 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _