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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HFM1
All Species:
8.18
Human Site:
S186
Identified Species:
16.36
UniProt:
A2PYH4
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
A2PYH4
NP_001017975.3
1435
162610
S186
S
N
D
N
E
L
D
S
H
I
G
S
V
K
I
Chimpanzee
Pan troglodytes
XP_524618
845
96632
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_537081
1567
175547
S215
R
P
R
C
C
A
W
S
R
G
G
P
R
Q
S
Cat
Felis silvestris
Mouse
Mus musculus
NP_808541
1434
161360
S185
D
G
S
L
N
L
S
S
H
I
S
P
V
K
L
Rat
Rattus norvegicus
XP_002724973
1434
161022
S185
N
G
N
L
S
L
N
S
H
I
S
P
A
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519189
952
107492
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001919555
1228
138324
S50
G
L
W
S
H
E
P
S
S
T
G
E
Q
A
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUV9
2142
244492
R386
G
E
A
R
G
S
K
R
G
K
G
D
A
E
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U2G0
2145
243812
S380
S
K
R
D
A
E
K
S
K
K
A
A
T
A
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002298526
984
111701
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_189410
1133
128271
Baker's Yeast
Sacchar. cerevisiae
P51979
1187
135053
L8
M
K
T
K
F
D
R
L
G
T
G
K
R
S
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
57.8
N.A.
43.7
N.A.
76.8
76.4
N.A.
48.7
N.A.
N.A.
47.1
N.A.
22.4
N.A.
21.9
N.A.
Protein Similarity:
100
58.2
N.A.
56.4
N.A.
86.3
85.7
N.A.
56.6
N.A.
N.A.
63.2
N.A.
38
N.A.
37.8
N.A.
P-Site Identity:
100
0
N.A.
13.3
N.A.
40
26.6
N.A.
0
N.A.
N.A.
13.3
N.A.
6.6
N.A.
13.3
N.A.
P-Site Similarity:
100
0
N.A.
20
N.A.
46.6
60
N.A.
0
N.A.
N.A.
26.6
N.A.
13.3
N.A.
26.6
N.A.
Percent
Protein Identity:
25.7
N.A.
N.A.
24.6
26.6
N.A.
Protein Similarity:
40.8
N.A.
N.A.
41.6
43.6
N.A.
P-Site Identity:
0
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
0
N.A.
N.A.
0
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
9
9
0
0
0
0
9
9
17
17
9
% A
% Cys:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
9
9
0
9
9
0
0
0
0
9
0
0
9
% D
% Glu:
0
9
0
0
9
17
0
0
0
0
0
9
0
9
0
% E
% Phe:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
17
17
0
0
9
0
0
0
17
9
42
0
0
0
0
% G
% His:
0
0
0
0
9
0
0
0
25
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
25
0
0
0
0
9
% I
% Lys:
0
17
0
9
0
0
17
0
9
17
0
9
0
17
0
% K
% Leu:
0
9
0
17
0
25
0
9
0
0
0
0
0
0
17
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
9
9
9
9
0
9
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
0
0
0
0
9
0
0
0
0
25
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
9
9
0
% Q
% Arg:
9
0
17
9
0
0
9
9
9
0
0
0
17
9
9
% R
% Ser:
17
0
9
9
9
9
9
50
9
0
17
9
0
9
9
% S
% Thr:
0
0
9
0
0
0
0
0
0
17
0
0
9
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
17
0
9
% V
% Trp:
0
0
9
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _