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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IGF2BP2
Full Name:
Insulin-like growth factor 2 mRNA-binding protein 2
Alias:
Hepatocellular carcinoma autoantigen p62; IF2B2; IGF2 mRNA-binding protein 2; IMP2; VICKZ2
Type:
RNA binding protein
Mass (Da):
66121
Number AA:
599
UniProt ID:
Q9Y6M1
International Prot ID:
IPI00179713
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044430
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0048027
GO:0000166
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
GO:0017148
GO:0042035
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y6
_
_
M
M
N
K
L
Y
I
G
N
L
S
P
A
Site 2
S11
K
L
Y
I
G
N
L
S
P
A
V
T
A
D
D
Site 3
T15
G
N
L
S
P
A
V
T
A
D
D
L
R
Q
L
Site 4
Y40
Q
V
L
L
K
S
G
Y
A
F
V
D
Y
P
D
Site 5
Y45
S
G
Y
A
F
V
D
Y
P
D
Q
N
W
A
I
Site 6
Y73
G
K
I
M
E
V
D
Y
S
V
S
K
K
L
R
Site 7
S74
K
I
M
E
V
D
Y
S
V
S
K
K
L
R
S
Site 8
T116
E
N
V
E
Q
V
N
T
D
T
E
T
A
V
V
Site 9
T120
Q
V
N
T
D
T
E
T
A
V
V
N
V
T
Y
Site 10
Y148
S
G
H
Q
F
E
N
Y
S
F
K
I
S
Y
I
Site 11
S153
E
N
Y
S
F
K
I
S
Y
I
P
D
E
E
V
Site 12
S161
Y
I
P
D
E
E
V
S
S
P
S
P
P
Q
R
Site 13
S162
I
P
D
E
E
V
S
S
P
S
P
P
Q
R
A
Site 14
S164
D
E
E
V
S
S
P
S
P
P
Q
R
A
Q
R
Site 15
S175
R
A
Q
R
G
D
H
S
S
R
E
Q
G
H
A
Site 16
S176
A
Q
R
G
D
H
S
S
R
E
Q
G
H
A
P
Site 17
S187
G
H
A
P
G
G
T
S
Q
A
R
Q
I
D
F
Site 18
T223
I
K
N
I
T
K
Q
T
Q
S
R
V
D
I
H
Site 19
T243
G
A
A
E
K
P
V
T
I
H
A
T
P
E
G
Site 20
T247
K
P
V
T
I
H
A
T
P
E
G
T
S
E
A
Site 21
T269
M
Q
K
E
A
D
E
T
K
L
A
E
E
I
P
Site 22
S317
I
S
S
L
Q
D
L
S
I
Y
N
P
E
R
T
Site 23
Y319
S
L
Q
D
L
S
I
Y
N
P
E
R
T
I
T
Site 24
T326
Y
N
P
E
R
T
I
T
V
K
G
T
V
E
A
Site 25
S382
S
T
G
L
S
V
L
S
P
P
A
G
P
R
G
Site 26
Y396
G
A
P
P
A
A
P
Y
H
P
F
T
T
H
S
Site 27
T400
A
A
P
Y
H
P
F
T
T
H
S
G
Y
F
S
Site 28
T401
A
P
Y
H
P
F
T
T
H
S
G
Y
F
S
S
Site 29
Y405
P
F
T
T
H
S
G
Y
F
S
S
L
Y
P
H
Site 30
S407
T
T
H
S
G
Y
F
S
S
L
Y
P
H
H
Q
Site 31
Y410
S
G
Y
F
S
S
L
Y
P
H
H
Q
F
G
P
Site 32
S423
G
P
F
P
H
H
H
S
Y
P
E
Q
E
I
V
Site 33
Y424
P
F
P
H
H
H
S
Y
P
E
Q
E
I
V
N
Site 34
S472
P
A
E
G
P
D
V
S
E
R
M
V
I
I
T
Site 35
T479
S
E
R
M
V
I
I
T
G
P
P
E
A
Q
F
Site 36
S518
E
A
H
I
R
V
P
S
S
T
A
G
R
V
I
Site 37
T520
H
I
R
V
P
S
S
T
A
G
R
V
I
G
K
Site 38
T531
V
I
G
K
G
G
K
T
V
N
E
L
Q
N
L
Site 39
S540
N
E
L
Q
N
L
T
S
A
E
V
I
V
P
R
Site 40
T550
V
I
V
P
R
D
Q
T
P
D
E
N
E
E
V
Site 41
Y589
V
K
Q
Q
E
Q
K
Y
P
Q
G
V
A
S
Q
Site 42
S595
K
Y
P
Q
G
V
A
S
Q
R
S
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation