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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IKK-gamma
Full Name:
NF-kappa-B essential modulator
Alias:
FIP3; FIP-3; I-kappa-B kinase gamma; IkB kinase gamma subunit; IkB kinase-associated protein 1; IKBKG; IKKAP1; IKKG; Inhibitor of nuclear factor kappa-B kinase gamma subunit; MFIP-3; NEMO; NF-kappaB essential modifier; NF-kappaB essential modulator
Type:
Adaptor/scaffold, Protein kinase, regulatory subunit
Mass (Da):
48198
Number AA:
419
UniProt ID:
Q9Y6K9
International Prot ID:
IPI00002411
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004871
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0050852
GO:0006955
GO:0006917
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
C
E
M
V
Q
P
S
G
G
P
A
A
D
Q
Site 2
S31
Q
D
V
L
G
E
E
S
P
L
G
K
P
A
M
Site 3
S43
P
A
M
L
H
L
P
S
E
Q
G
A
P
E
T
Site 4
T50
S
E
Q
G
A
P
E
T
L
Q
R
C
L
E
E
Site 5
S68
L
R
D
A
I
R
Q
S
N
Q
I
L
R
E
R
Site 6
S85
E
L
L
H
F
Q
A
S
Q
R
E
E
K
E
F
Site 7
S141
Q
M
A
E
D
K
A
S
V
K
A
Q
V
T
S
Site 8
S148
S
V
K
A
Q
V
T
S
L
L
G
E
L
Q
E
Site 9
S156
L
L
G
E
L
Q
E
S
Q
S
R
L
E
A
A
Site 10
S178
E
G
R
A
R
A
A
S
E
Q
A
R
Q
L
E
Site 11
S186
E
Q
A
R
Q
L
E
S
E
R
E
A
L
Q
Q
Site 12
S196
E
A
L
Q
Q
Q
H
S
V
Q
V
D
Q
L
R
Site 13
S208
Q
L
R
M
Q
G
Q
S
V
E
A
A
L
R
M
Site 14
S221
R
M
E
R
Q
A
A
S
E
E
K
R
K
L
A
Site 15
S247
E
Y
D
N
H
I
K
S
S
V
V
G
S
E
R
Site 16
S248
Y
D
N
H
I
K
S
S
V
V
G
S
E
R
K
Site 17
S252
I
K
S
S
V
V
G
S
E
R
K
R
G
M
Q
Site 18
T297
Q
H
K
I
V
M
E
T
V
P
V
L
K
A
Q
Site 19
Y308
L
K
A
Q
A
D
I
Y
K
A
D
F
Q
A
E
Site 20
Y340
L
E
Q
L
Q
R
E
Y
S
K
L
K
A
S
C
Site 21
S341
E
Q
L
Q
R
E
Y
S
K
L
K
A
S
C
Q
Site 22
S346
E
Y
S
K
L
K
A
S
C
Q
E
S
A
R
I
Site 23
S350
L
K
A
S
C
Q
E
S
A
R
I
E
D
M
R
Site 24
S364
R
K
R
H
V
E
V
S
Q
A
P
L
P
P
A
Site 25
Y374
P
L
P
P
A
P
A
Y
L
S
S
P
L
A
L
Site 26
S376
P
P
A
P
A
Y
L
S
S
P
L
A
L
P
S
Site 27
S377
P
A
P
A
Y
L
S
S
P
L
A
L
P
S
Q
Site 28
S383
S
S
P
L
A
L
P
S
Q
R
R
S
P
P
E
Site 29
S387
A
L
P
S
Q
R
R
S
P
P
E
E
P
P
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation