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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCN10A
Full Name:
Sodium channel protein type 10 subunit alpha
Alias:
Nav1.8; Peripheral nerve sodium channel 3; PN3; SCNAA; SNS; Sodium channel protein type 10 alpha; Sodium channel protein type X subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.8
Type:
Membrane, Voltage-gated sodium channel complex, Integral membrane protein
Mass (Da):
220626
Number AA:
1956
UniProt ID:
Q9Y5Y9
International Prot ID:
IPI00008522
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001518
Uniprot
OncoNet
Molecular Function:
GO:0031402
GO:0005248
PhosphoSite+
KinaseNET
Biological Process:
GO:0007600
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
T
N
N
F
R
R
F
T
P
E
S
L
V
E
I
Site 2
S20
F
R
R
F
T
P
E
S
L
V
E
I
E
K
Q
Site 3
Y86
L
E
D
L
D
P
F
Y
S
T
H
R
T
F
M
Site 4
T88
D
L
D
P
F
Y
S
T
H
R
T
F
M
V
L
Site 5
T91
P
F
Y
S
T
H
R
T
F
M
V
L
N
K
G
Site 6
T100
M
V
L
N
K
G
R
T
I
S
R
F
S
A
T
Site 7
S102
L
N
K
G
R
T
I
S
R
F
S
A
T
R
A
Site 8
S105
G
R
T
I
S
R
F
S
A
T
R
A
L
W
L
Site 9
S127
R
R
T
A
I
K
V
S
V
H
S
W
F
S
L
Site 10
T150
N
C
V
C
M
T
R
T
D
L
P
E
K
I
E
Site 11
T286
N
D
M
A
V
N
E
T
T
N
Y
S
S
H
R
Site 12
Y289
A
V
N
E
T
T
N
Y
S
S
H
R
K
P
D
Site 13
S291
N
E
T
T
N
Y
S
S
H
R
K
P
D
I
Y
Site 14
Y298
S
H
R
K
P
D
I
Y
I
N
K
R
G
T
S
Site 15
T304
I
Y
I
N
K
R
G
T
S
D
P
L
L
C
G
Site 16
S305
Y
I
N
K
R
G
T
S
D
P
L
L
C
G
N
Site 17
S314
P
L
L
C
G
N
G
S
D
S
G
H
C
P
D
Site 18
S316
L
C
G
N
G
S
D
S
G
H
C
P
D
G
Y
Site 19
Y323
S
G
H
C
P
D
G
Y
I
C
L
K
T
S
D
Site 20
T328
D
G
Y
I
C
L
K
T
S
D
N
P
D
F
N
Site 21
Y336
S
D
N
P
D
F
N
Y
T
S
F
D
S
F
A
Site 22
T354
L
S
L
F
R
L
M
T
Q
D
S
W
E
R
L
Site 23
Y362
Q
D
S
W
E
R
L
Y
Q
Q
T
L
R
T
S
Site 24
T365
W
E
R
L
Y
Q
Q
T
L
R
T
S
G
K
I
Site 25
T440
A
A
L
G
I
D
T
T
S
L
H
S
H
N
G
Site 26
S441
A
L
G
I
D
T
T
S
L
H
S
H
N
G
S
Site 27
S444
I
D
T
T
S
L
H
S
H
N
G
S
P
L
T
Site 28
S448
S
L
H
S
H
N
G
S
P
L
T
S
K
N
A
Site 29
T451
S
H
N
G
S
P
L
T
S
K
N
A
S
E
R
Site 30
S452
H
N
G
S
P
L
T
S
K
N
A
S
E
R
R
Site 31
S456
P
L
T
S
K
N
A
S
E
R
R
H
R
I
K
Site 32
S467
H
R
I
K
P
R
V
S
E
G
S
T
E
D
N
Site 33
S470
K
P
R
V
S
E
G
S
T
E
D
N
K
S
P
Site 34
T471
P
R
V
S
E
G
S
T
E
D
N
K
S
P
R
Site 35
S476
G
S
T
E
D
N
K
S
P
R
S
D
P
Y
N
Site 36
S479
E
D
N
K
S
P
R
S
D
P
Y
N
Q
R
R
Site 37
Y482
K
S
P
R
S
D
P
Y
N
Q
R
R
M
S
F
Site 38
S488
P
Y
N
Q
R
R
M
S
F
L
G
L
A
S
G
Site 39
S494
M
S
F
L
G
L
A
S
G
K
R
R
A
S
H
Site 40
S500
A
S
G
K
R
R
A
S
H
G
S
V
F
H
F
Site 41
S503
K
R
R
A
S
H
G
S
V
F
H
F
R
S
P
Site 42
S509
G
S
V
F
H
F
R
S
P
G
R
D
I
S
L
Site 43
S515
R
S
P
G
R
D
I
S
L
P
E
G
V
T
D
Site 44
S532
V
F
P
G
D
H
E
S
H
R
G
S
L
L
L
Site 45
S536
D
H
E
S
H
R
G
S
L
L
L
G
G
G
A
Site 46
S552
Q
Q
G
P
L
P
R
S
P
L
P
Q
P
S
N
Site 47
S558
R
S
P
L
P
Q
P
S
N
P
D
S
R
H
G
Site 48
S562
P
Q
P
S
N
P
D
S
R
H
G
E
D
E
H
Site 49
S575
E
H
Q
P
P
P
T
S
E
L
A
P
G
A
V
Site 50
T594
F
D
A
G
Q
K
K
T
F
L
S
A
E
Y
L
Site 51
S627
V
L
E
E
L
E
E
S
E
Q
K
C
P
P
C
Site 52
S639
P
P
C
L
T
S
L
S
Q
K
Y
L
I
W
D
Site 53
S690
A
M
E
H
H
G
M
S
P
T
F
E
A
M
L
Site 54
T692
E
H
H
G
M
S
P
T
F
E
A
M
L
Q
I
Site 55
Y722
K
I
I
A
F
D
P
Y
Y
Y
F
Q
K
K
W
Site 56
Y723
I
I
A
F
D
P
Y
Y
Y
F
Q
K
K
W
N
Site 57
Y724
I
A
F
D
P
Y
Y
Y
F
Q
K
K
W
N
I
Site 58
S769
R
V
F
K
L
A
K
S
W
P
T
L
N
T
L
Site 59
T775
K
S
W
P
T
L
N
T
L
I
K
I
I
G
N
Site 60
T899
S
F
S
A
D
N
L
T
A
P
E
D
D
G
E
Site 61
S930
R
T
K
Q
A
L
C
S
F
F
S
R
S
C
P
Site 62
S933
Q
A
L
C
S
F
F
S
R
S
C
P
F
P
Q
Site 63
S935
L
C
S
F
F
S
R
S
C
P
F
P
Q
P
K
Site 64
S954
L
V
V
K
L
P
L
S
S
S
K
A
E
N
H
Site 65
S956
V
K
L
P
L
S
S
S
K
A
E
N
H
I
A
Site 66
T966
E
N
H
I
A
A
N
T
A
R
G
S
S
G
G
Site 67
S970
A
A
N
T
A
R
G
S
S
G
G
L
Q
A
P
Site 68
S971
A
N
T
A
R
G
S
S
G
G
L
Q
A
P
R
Site 69
S985
R
G
P
R
D
E
H
S
D
F
I
A
N
P
T
Site 70
S1019
D
G
G
E
D
A
Q
S
F
Q
Q
E
V
I
P
Site 71
T1044
E
R
C
G
D
H
L
T
P
R
S
P
G
T
G
Site 72
S1047
G
D
H
L
T
P
R
S
P
G
T
G
T
S
S
Site 73
T1050
L
T
P
R
S
P
G
T
G
T
S
S
E
D
L
Site 74
S1053
R
S
P
G
T
G
T
S
S
E
D
L
A
P
S
Site 75
S1054
S
P
G
T
G
T
S
S
E
D
L
A
P
S
L
Site 76
S1060
S
S
E
D
L
A
P
S
L
G
E
T
W
K
D
Site 77
T1064
L
A
P
S
L
G
E
T
W
K
D
E
S
V
P
Site 78
S1069
G
E
T
W
K
D
E
S
V
P
Q
V
P
A
E
Site 79
T1081
P
A
E
G
V
D
D
T
S
S
S
E
G
S
T
Site 80
S1082
A
E
G
V
D
D
T
S
S
S
E
G
S
T
V
Site 81
S1083
E
G
V
D
D
T
S
S
S
E
G
S
T
V
D
Site 82
S1084
G
V
D
D
T
S
S
S
E
G
S
T
V
D
C
Site 83
S1087
D
T
S
S
S
E
G
S
T
V
D
C
L
D
P
Site 84
T1088
T
S
S
S
E
G
S
T
V
D
C
L
D
P
E
Site 85
Y1174
G
S
L
A
F
E
D
Y
Y
L
D
Q
K
P
T
Site 86
Y1175
S
L
A
F
E
D
Y
Y
L
D
Q
K
P
T
V
Site 87
T1181
Y
Y
L
D
Q
K
P
T
V
K
A
L
L
E
Y
Site 88
Y1188
T
V
K
A
L
L
E
Y
T
D
R
V
F
T
F
Site 89
Y1208
M
L
L
K
W
V
A
Y
G
F
K
K
Y
F
T
Site 90
S1262
L
R
P
L
R
A
L
S
R
F
E
G
M
R
V
Site 91
Y1313
K
F
W
R
C
I
N
Y
T
D
G
E
F
S
L
Site 92
S1324
E
F
S
L
V
P
L
S
I
V
N
N
K
S
D
Site 93
S1330
L
S
I
V
N
N
K
S
D
C
K
I
Q
N
S
Site 94
Y1374
K
G
W
M
D
I
M
Y
A
A
V
D
S
R
E
Site 95
T1436
G
G
Q
D
I
F
M
T
E
E
Q
K
K
Y
Y
Site 96
Y1442
M
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
Site 97
Y1443
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
G
Site 98
S1501
M
V
E
T
D
D
Q
S
E
E
K
T
K
I
L
Site 99
T1505
D
D
Q
S
E
E
K
T
K
I
L
G
K
I
N
Site 100
Y1677
I
L
N
T
G
P
P
Y
C
D
P
N
L
P
N
Site 101
S1685
C
D
P
N
L
P
N
S
N
G
T
R
G
D
C
Site 102
S1732
F
N
V
A
T
E
E
S
T
E
P
L
S
E
D
Site 103
S1737
E
E
S
T
E
P
L
S
E
D
D
F
D
M
F
Site 104
Y1745
E
D
D
F
D
M
F
Y
E
T
W
E
K
F
D
Site 105
S1772
S
D
F
A
D
T
L
S
G
P
L
R
I
P
K
Site 106
S1820
G
E
S
G
E
L
D
S
L
K
A
N
M
E
E
Site 107
S1835
K
F
M
A
T
N
L
S
K
S
S
Y
E
P
I
Site 108
S1837
M
A
T
N
L
S
K
S
S
Y
E
P
I
A
T
Site 109
Y1839
T
N
L
S
K
S
S
Y
E
P
I
A
T
T
L
Site 110
T1844
S
S
Y
E
P
I
A
T
T
L
R
W
K
Q
E
Site 111
T1845
S
Y
E
P
I
A
T
T
L
R
W
K
Q
E
D
Site 112
S1854
R
W
K
Q
E
D
I
S
A
T
V
I
Q
K
A
Site 113
T1856
K
Q
E
D
I
S
A
T
V
I
Q
K
A
Y
R
Site 114
Y1862
A
T
V
I
Q
K
A
Y
R
S
Y
V
L
H
R
Site 115
Y1865
I
Q
K
A
Y
R
S
Y
V
L
H
R
S
M
A
Site 116
S1870
R
S
Y
V
L
H
R
S
M
A
L
S
N
T
P
Site 117
S1874
L
H
R
S
M
A
L
S
N
T
P
C
V
P
R
Site 118
T1876
R
S
M
A
L
S
N
T
P
C
V
P
R
A
E
Site 119
S1888
R
A
E
E
E
A
A
S
L
P
D
E
G
F
V
Site 120
S1909
N
C
V
L
P
D
K
S
E
T
A
S
A
T
S
Site 121
S1913
P
D
K
S
E
T
A
S
A
T
S
F
P
P
S
Site 122
S1916
S
E
T
A
S
A
T
S
F
P
P
S
Y
E
S
Site 123
S1920
S
A
T
S
F
P
P
S
Y
E
S
V
T
R
G
Site 124
Y1921
A
T
S
F
P
P
S
Y
E
S
V
T
R
G
L
Site 125
S1923
S
F
P
P
S
Y
E
S
V
T
R
G
L
S
D
Site 126
T1925
P
P
S
Y
E
S
V
T
R
G
L
S
D
R
V
Site 127
S1929
E
S
V
T
R
G
L
S
D
R
V
N
M
R
T
Site 128
T1936
S
D
R
V
N
M
R
T
S
S
S
I
Q
N
E
Site 129
S1937
D
R
V
N
M
R
T
S
S
S
I
Q
N
E
D
Site 130
S1938
R
V
N
M
R
T
S
S
S
I
Q
N
E
D
E
Site 131
S1939
V
N
M
R
T
S
S
S
I
Q
N
E
D
E
A
Site 132
T1947
I
Q
N
E
D
E
A
T
S
M
E
L
I
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation