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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GCFC
Full Name:
GC-rich sequence DNA-binding factor 1
Alias:
C21orf66; Chromosome 21 open reading frame 66; FSAP105; Functional spliceosome-associated protein 105; GC-rich sequence DNA-binding factor homolog
Type:
Transcription protein
Mass (Da):
104804
Number AA:
917
UniProt ID:
Q9Y5B6
International Prot ID:
IPI00001364
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003700
GO:0003677
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
N
V
R
K
R
N
D
S
E
E
E
E
R
E
R
Site 2
T38
P
L
L
P
P
P
G
T
G
E
E
A
G
P
G
Site 3
S55
D
R
A
P
G
G
E
S
L
L
G
P
G
P
S
Site 4
S62
S
L
L
G
P
G
P
S
P
P
S
A
L
T
P
Site 5
S65
G
P
G
P
S
P
P
S
A
L
T
P
G
L
G
Site 6
T68
P
S
P
P
S
A
L
T
P
G
L
G
A
E
A
Site 7
S105
N
K
E
V
P
R
A
S
L
L
S
F
Q
D
E
Site 8
S108
V
P
R
A
S
L
L
S
F
Q
D
E
E
E
E
Site 9
S125
E
V
F
K
V
K
K
S
S
Y
S
K
K
I
V
Site 10
S126
V
F
K
V
K
K
S
S
Y
S
K
K
I
V
K
Site 11
S146
Y
K
E
D
L
E
K
S
K
I
K
T
E
L
N
Site 12
T150
L
E
K
S
K
I
K
T
E
L
N
S
S
A
E
Site 13
S154
K
I
K
T
E
L
N
S
S
A
E
S
E
Q
P
Site 14
S155
I
K
T
E
L
N
S
S
A
E
S
E
Q
P
L
Site 15
S158
E
L
N
S
S
A
E
S
E
Q
P
L
D
K
T
Site 16
T165
S
E
Q
P
L
D
K
T
G
H
V
K
D
T
N
Site 17
S180
Q
E
D
G
V
I
I
S
E
H
G
E
D
E
M
Site 18
S191
E
D
E
M
D
M
E
S
E
K
E
E
E
K
P
Site 19
T200
K
E
E
E
K
P
K
T
G
G
A
F
S
N
A
Site 20
S205
P
K
T
G
G
A
F
S
N
A
L
S
S
L
N
Site 21
T242
A
R
E
L
G
D
F
T
P
H
D
N
E
P
G
Site 22
S262
R
E
D
E
N
D
A
S
D
D
E
D
D
D
E
Site 23
S276
E
K
R
R
I
V
F
S
V
K
E
K
S
Q
R
Site 24
S281
V
F
S
V
K
E
K
S
Q
R
Q
K
I
A
E
Site 25
S295
E
E
I
G
I
E
G
S
D
D
D
A
L
V
T
Site 26
S329
N
I
P
Q
V
Q
A
S
Q
P
A
E
V
N
M
Site 27
Y337
Q
P
A
E
V
N
M
Y
Y
Q
N
T
Y
Q
T
Site 28
Y338
P
A
E
V
N
M
Y
Y
Q
N
T
Y
Q
T
M
Site 29
Y347
N
T
Y
Q
T
M
P
Y
G
S
S
Y
G
I
P
Site 30
Y351
T
M
P
Y
G
S
S
Y
G
I
P
Y
S
Y
T
Site 31
S356
S
S
Y
G
I
P
Y
S
Y
T
A
Y
G
S
S
Site 32
Y357
S
Y
G
I
P
Y
S
Y
T
A
Y
G
S
S
D
Site 33
T358
Y
G
I
P
Y
S
Y
T
A
Y
G
S
S
D
A
Site 34
Y360
I
P
Y
S
Y
T
A
Y
G
S
S
D
A
K
S
Site 35
S363
S
Y
T
A
Y
G
S
S
D
A
K
S
Q
K
T
Site 36
S367
Y
G
S
S
D
A
K
S
Q
K
T
D
N
T
V
Site 37
T370
S
D
A
K
S
Q
K
T
D
N
T
V
P
F
K
Site 38
T373
K
S
Q
K
T
D
N
T
V
P
F
K
T
P
S
Site 39
T378
D
N
T
V
P
F
K
T
P
S
N
E
M
T
P
Site 40
S380
T
V
P
F
K
T
P
S
N
E
M
T
P
V
T
Site 41
T384
K
T
P
S
N
E
M
T
P
V
T
I
D
L
V
Site 42
S401
Q
L
K
D
R
L
D
S
M
K
E
L
H
K
T
Site 43
T408
S
M
K
E
L
H
K
T
N
R
Q
Q
H
E
K
Site 44
S419
Q
H
E
K
H
L
Q
S
R
V
D
S
T
R
A
Site 45
S423
H
L
Q
S
R
V
D
S
T
R
A
I
E
R
L
Site 46
S433
A
I
E
R
L
E
G
S
S
G
G
I
G
E
R
Site 47
S434
I
E
R
L
E
G
S
S
G
G
I
G
E
R
Y
Site 48
Y441
S
G
G
I
G
E
R
Y
K
F
L
Q
E
M
R
Site 49
Y450
F
L
Q
E
M
R
G
Y
V
Q
D
L
L
E
C
Site 50
Y476
E
S
A
I
H
Q
L
Y
K
Q
R
A
S
R
L
Site 51
S481
Q
L
Y
K
Q
R
A
S
R
L
V
Q
R
R
Q
Site 52
S495
Q
D
D
I
K
D
E
S
S
E
F
S
S
H
S
Site 53
S496
D
D
I
K
D
E
S
S
E
F
S
S
H
S
N
Site 54
S499
K
D
E
S
S
E
F
S
S
H
S
N
K
A
L
Site 55
S500
D
E
S
S
E
F
S
S
H
S
N
K
A
L
M
Site 56
S502
S
S
E
F
S
S
H
S
N
K
A
L
M
A
P
Site 57
S513
L
M
A
P
N
L
D
S
F
G
R
D
R
A
L
Site 58
Y521
F
G
R
D
R
A
L
Y
Q
E
H
A
K
R
R
Site 59
T537
A
E
R
E
A
R
R
T
R
R
R
Q
A
R
E
Site 60
T546
R
R
Q
A
R
E
Q
T
G
K
M
A
D
H
L
Site 61
S557
A
D
H
L
E
G
L
S
S
D
D
E
E
T
S
Site 62
S558
D
H
L
E
G
L
S
S
D
D
E
E
T
S
T
Site 63
T563
L
S
S
D
D
E
E
T
S
T
D
I
T
N
F
Site 64
S564
S
S
D
D
E
E
T
S
T
D
I
T
N
F
N
Site 65
T565
S
D
D
E
E
T
S
T
D
I
T
N
F
N
L
Site 66
T568
E
E
T
S
T
D
I
T
N
F
N
L
E
K
D
Site 67
S578
N
L
E
K
D
R
I
S
K
E
S
G
K
V
F
Site 68
S581
K
D
R
I
S
K
E
S
G
K
V
F
E
D
V
Site 69
S594
D
V
L
E
S
F
Y
S
I
D
C
I
K
S
Q
Site 70
Y609
F
E
A
W
R
S
K
Y
Y
T
S
Y
K
D
A
Site 71
Y610
E
A
W
R
S
K
Y
Y
T
S
Y
K
D
A
Y
Site 72
Y613
R
S
K
Y
Y
T
S
Y
K
D
A
Y
I
G
L
Site 73
Y617
Y
T
S
Y
K
D
A
Y
I
G
L
C
L
P
K
Site 74
T638
R
L
Q
L
L
T
W
T
P
L
E
A
K
C
R
Site 75
Y659
W
F
E
S
L
L
F
Y
G
C
E
E
R
E
Q
Site 76
T704
D
P
F
S
T
T
Q
T
S
R
M
V
G
I
T
Site 77
Y718
T
L
K
L
I
N
G
Y
P
S
V
V
N
A
E
Site 78
S720
K
L
I
N
G
Y
P
S
V
V
N
A
E
N
K
Site 79
T729
V
N
A
E
N
K
N
T
Q
V
Y
L
K
A
L
Site 80
Y732
E
N
K
N
T
Q
V
Y
L
K
A
L
L
L
R
Site 81
Y753
D
D
V
F
M
P
L
Y
P
K
N
V
L
E
N
Site 82
S763
N
V
L
E
N
K
N
S
G
P
Y
L
F
F
Q
Site 83
Y787
L
G
N
F
L
Q
W
Y
G
I
F
S
N
K
T
Site 84
T794
Y
G
I
F
S
N
K
T
L
Q
E
L
S
I
D
Site 85
Y817
M
A
F
Q
N
S
E
Y
G
D
D
S
I
K
K
Site 86
S821
N
S
E
Y
G
D
D
S
I
K
K
A
Q
N
V
Site 87
S847
L
K
G
E
R
T
I
S
Q
L
E
N
F
C
R
Site 88
Y855
Q
L
E
N
F
C
R
Y
L
V
H
L
A
D
T
Site 89
S867
A
D
T
I
Y
R
N
S
I
G
C
S
D
V
E
Site 90
S871
Y
R
N
S
I
G
C
S
D
V
E
K
R
N
A
Site 91
S900
R
A
L
D
H
A
M
S
V
A
S
D
H
N
V
Site 92
S912
H
N
V
K
E
F
K
S
L
I
E
G
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation