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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SAMHD1
Full Name:
SAM domain and HD domain-containing protein 1
Alias:
AGS5; Aicardi-Goutieres syndrome 5; DCIP; Dendritic cell-derived IFNG-induced protein; HD domain containing 1; HDDC1; Mg11; Monocyte protein 5; MOP5; MOP-5; SAM domain and HD domain 1; SAMH1; SBBI88
Type:
Unknown function
Mass (Da):
72201
Number AA:
626
UniProt ID:
Q9Y3Z3
International Prot ID:
IPI00294739
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0002376
GO:0006955
GO:0050896
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
Q
R
A
D
S
E
Q
P
S
K
R
P
Site 2
S10
R
A
D
S
E
Q
P
S
K
R
P
R
C
D
D
Site 3
S18
K
R
P
R
C
D
D
S
P
R
T
P
S
N
T
Site 4
T21
R
C
D
D
S
P
R
T
P
S
N
T
P
S
A
Site 5
S23
D
D
S
P
R
T
P
S
N
T
P
S
A
E
A
Site 6
T25
S
P
R
T
P
S
N
T
P
S
A
E
A
D
W
Site 7
S27
R
T
P
S
N
T
P
S
A
E
A
D
W
S
P
Site 8
S33
P
S
A
E
A
D
W
S
P
G
L
E
L
H
P
Site 9
Y42
G
L
E
L
H
P
D
Y
K
T
W
G
P
E
Q
Site 10
T44
E
L
H
P
D
Y
K
T
W
G
P
E
Q
V
C
Site 11
S102
G
E
R
K
K
L
L
S
Y
I
Q
R
L
V
Q
Site 12
Y103
E
R
K
K
L
L
S
Y
I
Q
R
L
V
Q
I
Site 13
T138
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Site 14
Y146
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Site 15
Y155
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
Site 16
S168
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
Site 17
S192
K
Q
P
E
L
Q
I
S
E
R
D
V
L
C
V
Site 18
T232
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
Site 19
S278
Q
I
V
G
P
L
E
S
P
V
E
D
S
L
W
Site 20
S283
L
E
S
P
V
E
D
S
L
W
P
Y
K
G
R
Site 21
Y287
V
E
D
S
L
W
P
Y
K
G
R
P
E
N
K
Site 22
S295
K
G
R
P
E
N
K
S
F
L
Y
E
I
V
S
Site 23
Y298
P
E
N
K
S
F
L
Y
E
I
V
S
N
K
R
Site 24
S302
S
F
L
Y
E
I
V
S
N
K
R
N
G
I
D
Site 25
Y315
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
Site 26
Y331
G
I
Q
N
N
F
D
Y
K
R
F
I
K
F
A
Site 27
Y360
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
Site 28
Y374
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
Site 29
T384
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
Site 30
T387
N
I
I
D
T
M
I
T
D
A
F
L
K
A
D
Site 31
Y407
T
G
A
G
G
K
K
Y
R
I
S
T
A
I
D
Site 32
S410
G
G
K
K
Y
R
I
S
T
A
I
D
D
M
E
Site 33
T411
G
K
K
Y
R
I
S
T
A
I
D
D
M
E
A
Site 34
Y419
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
Site 35
Y432
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
Site 36
S433
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
Site 37
Y450
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
Site 38
Y456
E
Y
R
N
L
F
K
Y
V
G
E
T
Q
P
T
Site 39
T463
Y
V
G
E
T
Q
P
T
G
Q
I
K
I
K
R
Site 40
Y473
I
K
I
K
R
E
D
Y
E
S
L
P
K
E
V
Site 41
S475
I
K
R
E
D
Y
E
S
L
P
K
E
V
A
S
Site 42
S482
S
L
P
K
E
V
A
S
A
K
P
K
V
L
L
Site 43
Y507
V
D
V
I
N
M
D
Y
G
M
Q
E
K
N
P
Site 44
Y521
P
I
D
H
V
S
F
Y
C
K
T
A
P
N
R
Site 45
T533
P
N
R
A
I
R
I
T
K
N
Q
V
S
Q
L
Site 46
S538
R
I
T
K
N
Q
V
S
Q
L
L
P
E
K
F
Site 47
Y553
A
E
Q
L
I
R
V
Y
C
K
K
V
D
R
K
Site 48
S561
C
K
K
V
D
R
K
S
L
Y
A
A
R
Q
Y
Site 49
Y563
K
V
D
R
K
S
L
Y
A
A
R
Q
Y
F
V
Site 50
Y568
S
L
Y
A
A
R
Q
Y
F
V
Q
W
C
A
D
Site 51
T579
W
C
A
D
R
N
F
T
K
P
Q
D
G
D
V
Site 52
T592
D
V
I
A
P
L
I
T
P
Q
K
K
E
W
N
Site 53
S601
Q
K
K
E
W
N
D
S
T
S
V
Q
N
P
T
Site 54
T602
K
K
E
W
N
D
S
T
S
V
Q
N
P
T
R
Site 55
S603
K
E
W
N
D
S
T
S
V
Q
N
P
T
R
L
Site 56
S614
P
T
R
L
R
E
A
S
K
S
R
V
Q
L
F
Site 57
S616
R
L
R
E
A
S
K
S
R
V
Q
L
F
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation