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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GIT1
Full Name:
ARF GTPase-activating protein GIT1
Alias:
Cool-associated and tyrosine-phosphorylated protein 1; G protein-coupled receptor kinase interacting ArfGAP 1; G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1
Type:
GTPase-activating protein for G protein
Mass (Da):
84341
Number AA:
761
UniProt ID:
Q9Y2X7
International Prot ID:
IPI00383987
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005925
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0032312
GO:0008277
Phosida
TranscriptoNet
STRING
Kinexus Products
ARF GTPase-activating protein GIT1 pan-specific antibody AB-NN261-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN261-1#ARF GTPase-activating protein GIT1 Y545 phosphosite-specific antibody AB-PN517#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN517#ARF GTPase-activating protein GIT1 (D542-H548, human) pY545 phosphopeptide - Powder PE-04AEN99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEN99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
E
C
C
S
V
H
R
S
L
G
R
H
I
S
I
Site 2
S46
R
S
L
G
R
H
I
S
I
V
K
H
L
R
H
Site 3
T59
R
H
S
A
W
P
P
T
L
L
Q
M
V
H
T
Site 4
S88
L
D
P
A
Q
V
Q
S
G
R
R
K
A
N
P
Site 5
S104
D
K
V
H
P
I
K
S
E
F
I
R
A
K
Y
Site 6
Y111
S
E
F
I
R
A
K
Y
Q
M
L
A
F
V
H
Site 7
S134
G
V
T
A
K
D
L
S
K
Q
L
H
S
S
V
Site 8
S139
D
L
S
K
Q
L
H
S
S
V
R
T
G
N
L
Site 9
S140
L
S
K
Q
L
H
S
S
V
R
T
G
N
L
E
Site 10
T168
F
F
H
P
E
K
G
T
T
P
L
H
V
A
A
Site 11
T169
F
H
P
E
K
G
T
T
P
L
H
V
A
A
K
Site 12
S195
V
Y
G
A
D
P
G
S
P
D
V
N
G
R
T
Site 13
T202
S
P
D
V
N
G
R
T
P
I
D
Y
A
R
Q
Site 14
Y206
N
G
R
T
P
I
D
Y
A
R
Q
A
G
H
H
Site 15
Y224
E
R
L
V
E
C
Q
Y
E
L
T
D
R
L
A
Site 16
Y233
L
T
D
R
L
A
F
Y
L
C
G
R
K
P
D
Site 17
Y246
P
D
H
K
N
G
H
Y
I
I
P
Q
M
A
D
Site 18
S258
M
A
D
S
L
D
L
S
E
L
A
K
A
A
K
Site 19
S272
K
K
K
L
Q
A
L
S
N
R
L
F
E
E
L
Site 20
Y284
E
E
L
A
M
D
V
Y
D
E
V
D
R
R
E
Site 21
T299
N
D
A
V
W
L
A
T
Q
N
H
S
T
L
V
Site 22
T307
Q
N
H
S
T
L
V
T
E
R
S
A
V
P
F
Site 23
Y321
F
L
P
V
N
P
E
Y
S
A
T
R
N
Q
G
Site 24
T324
V
N
P
E
Y
S
A
T
R
N
Q
G
R
Q
K
Site 25
S349
T
L
I
I
D
I
L
S
E
A
K
R
R
Q
Q
Site 26
S359
K
R
R
Q
Q
G
K
S
L
S
S
P
T
D
N
Site 27
S361
R
Q
Q
G
K
S
L
S
S
P
T
D
N
L
E
Site 28
S362
Q
Q
G
K
S
L
S
S
P
T
D
N
L
E
L
Site 29
T364
G
K
S
L
S
S
P
T
D
N
L
E
L
S
L
Site 30
S370
P
T
D
N
L
E
L
S
L
R
S
Q
S
D
L
Site 31
S373
N
L
E
L
S
L
R
S
Q
S
D
L
D
D
Q
Site 32
S375
E
L
S
L
R
S
Q
S
D
L
D
D
Q
H
D
Site 33
Y383
D
L
D
D
Q
H
D
Y
D
S
V
A
S
D
E
Site 34
S385
D
D
Q
H
D
Y
D
S
V
A
S
D
E
D
T
Site 35
S388
H
D
Y
D
S
V
A
S
D
E
D
T
D
Q
E
Site 36
T392
S
V
A
S
D
E
D
T
D
Q
E
P
L
R
S
Site 37
S399
T
D
Q
E
P
L
R
S
T
G
A
T
R
S
N
Site 38
T400
D
Q
E
P
L
R
S
T
G
A
T
R
S
N
R
Site 39
T403
P
L
R
S
T
G
A
T
R
S
N
R
A
R
S
Site 40
S405
R
S
T
G
A
T
R
S
N
R
A
R
S
M
D
Site 41
S410
T
R
S
N
R
A
R
S
M
D
S
S
D
L
S
Site 42
S413
N
R
A
R
S
M
D
S
S
D
L
S
D
G
A
Site 43
S414
R
A
R
S
M
D
S
S
D
L
S
D
G
A
V
Site 44
S417
S
M
D
S
S
D
L
S
D
G
A
V
T
L
Q
Site 45
S448
Q
Q
L
M
K
V
N
S
S
L
S
D
E
L
R
Site 46
S449
Q
L
M
K
V
N
S
S
L
S
D
E
L
R
R
Site 47
S451
M
K
V
N
S
S
L
S
D
E
L
R
R
L
Q
Site 48
T480
Q
P
P
G
P
V
P
T
P
P
L
P
S
E
R
Site 49
S485
V
P
T
P
P
L
P
S
E
R
A
E
H
T
P
Site 50
T491
P
S
E
R
A
E
H
T
P
M
A
P
G
G
S
Site 51
S498
T
P
M
A
P
G
G
S
T
H
R
R
D
R
Q
Site 52
T499
P
M
A
P
G
G
S
T
H
R
R
D
R
Q
A
Site 53
S508
R
R
D
R
Q
A
F
S
M
Y
E
P
G
S
A
Site 54
Y510
D
R
Q
A
F
S
M
Y
E
P
G
S
A
L
K
Site 55
S514
F
S
M
Y
E
P
G
S
A
L
K
P
F
G
G
Site 56
T528
G
P
P
G
D
E
L
T
T
R
L
Q
P
F
H
Site 57
S536
T
R
L
Q
P
F
H
S
T
E
L
E
D
D
A
Site 58
T537
R
L
Q
P
F
H
S
T
E
L
E
D
D
A
I
Site 59
Y545
E
L
E
D
D
A
I
Y
S
V
H
V
P
A
G
ARF GTPase-activating protein GIT1 Y545 phosphosite-specific antibody AB-PN517#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN517#ARF GTPase-activating protein GIT1 (D542-H548, human) pY545 phosphopeptide - Powder PE-04AEN99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AEN99
Site 60
S546
L
E
D
D
A
I
Y
S
V
H
V
P
A
G
L
Site 61
Y554
V
H
V
P
A
G
L
Y
R
I
R
K
G
V
S
Site 62
S561
Y
R
I
R
K
G
V
S
A
S
A
V
P
F
T
Site 63
S570
S
A
V
P
F
T
P
S
S
P
L
L
S
C
S
Site 64
S571
A
V
P
F
T
P
S
S
P
L
L
S
C
S
Q
Site 65
S575
T
P
S
S
P
L
L
S
C
S
Q
E
G
S
R
Site 66
S577
S
S
P
L
L
S
C
S
Q
E
G
S
R
H
T
Site 67
S581
L
S
C
S
Q
E
G
S
R
H
T
S
K
L
S
Site 68
T584
S
Q
E
G
S
R
H
T
S
K
L
S
R
H
G
Site 69
S585
Q
E
G
S
R
H
T
S
K
L
S
R
H
G
S
Site 70
S588
S
R
H
T
S
K
L
S
R
H
G
S
G
A
D
Site 71
S592
S
K
L
S
R
H
G
S
G
A
D
S
D
Y
E
Site 72
S596
R
H
G
S
G
A
D
S
D
Y
E
N
T
Q
S
Site 73
Y598
G
S
G
A
D
S
D
Y
E
N
T
Q
S
G
D
Site 74
T601
A
D
S
D
Y
E
N
T
Q
S
G
D
P
L
L
Site 75
S603
S
D
Y
E
N
T
Q
S
G
D
P
L
L
G
L
Site 76
S630
D
F
H
P
E
L
E
S
L
D
G
D
L
D
P
Site 77
S641
D
L
D
P
G
L
P
S
T
E
D
V
I
L
K
Site 78
T642
L
D
P
G
L
P
S
T
E
D
V
I
L
K
T
Site 79
S670
A
Q
E
F
K
H
D
S
F
V
P
C
S
E
K
Site 80
S700
P
A
L
E
P
V
R
S
S
L
R
L
L
N
A
Site 81
S708
S
L
R
L
L
N
A
S
A
Y
R
L
Q
S
E
Site 82
Y710
R
L
L
N
A
S
A
Y
R
L
Q
S
E
C
R
Site 83
S714
A
S
A
Y
R
L
Q
S
E
C
R
K
T
V
P
Site 84
T719
L
Q
S
E
C
R
K
T
V
P
P
E
P
G
A
Site 85
T753
K
A
A
K
Q
L
V
T
I
T
T
R
E
K
K
Site 86
T755
A
K
Q
L
V
T
I
T
T
R
E
K
K
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation