KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LEMD3
Full Name:
Inner nuclear membrane protein Man1
Alias:
LEM domain containing 3; LEM domain-containing protein 3; MAN1
Type:
Nuclear envelope; Membrane protein, integral
Mass (Da):
99997
Number AA:
911
UniProt ID:
Q9Y2U8
International Prot ID:
IPI00032491
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005639
GO:0005624
GO:0005626
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0000166
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030514
GO:0032926
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
A
A
A
A
S
A
P
Q
Q
L
S
D
Site 2
S13
A
S
A
P
Q
Q
L
S
D
E
E
L
F
S
Q
Site 3
S19
L
S
D
E
E
L
F
S
Q
L
R
R
Y
G
L
Site 4
Y24
L
F
S
Q
L
R
R
Y
G
L
S
P
G
P
V
Site 5
S27
Q
L
R
R
Y
G
L
S
P
G
P
V
T
E
S
Site 6
T32
G
L
S
P
G
P
V
T
E
S
T
R
P
V
Y
Site 7
S34
S
P
G
P
V
T
E
S
T
R
P
V
Y
L
K
Site 8
T35
P
G
P
V
T
E
S
T
R
P
V
Y
L
K
K
Site 9
Y39
T
E
S
T
R
P
V
Y
L
K
K
L
K
K
L
Site 10
T63
S
G
G
R
G
N
K
T
R
N
S
N
N
N
N
Site 11
S66
R
G
N
K
T
R
N
S
N
N
N
N
T
A
A
Site 12
S95
G
M
G
V
R
P
V
S
G
D
L
S
Y
L
R
Site 13
S99
R
P
V
S
G
D
L
S
Y
L
R
T
P
G
G
Site 14
Y100
P
V
S
G
D
L
S
Y
L
R
T
P
G
G
L
Site 15
T103
G
D
L
S
Y
L
R
T
P
G
G
L
C
R
I
Site 16
S111
P
G
G
L
C
R
I
S
A
S
G
P
E
S
L
Site 17
S117
I
S
A
S
G
P
E
S
L
L
G
G
P
G
G
Site 18
S140
S
K
V
L
L
G
F
S
S
D
E
S
D
V
E
Site 19
S141
K
V
L
L
G
F
S
S
D
E
S
D
V
E
A
Site 20
S144
L
G
F
S
S
D
E
S
D
V
E
A
S
P
R
Site 21
S149
D
E
S
D
V
E
A
S
P
R
D
Q
A
G
G
Site 22
S164
G
G
R
K
D
R
A
S
L
Q
Y
R
G
L
K
Site 23
S180
P
P
A
P
L
A
A
S
E
V
T
N
S
N
S
Site 24
S185
A
A
S
E
V
T
N
S
N
S
A
E
R
R
K
Site 25
S187
S
E
V
T
N
S
N
S
A
E
R
R
K
P
H
Site 26
S195
A
E
R
R
K
P
H
S
W
W
G
A
R
R
P
Site 27
T209
P
A
G
P
E
L
Q
T
P
P
G
K
D
G
A
Site 28
T234
G
E
E
R
D
P
E
T
E
E
P
L
W
A
S
Site 29
T243
E
P
L
W
A
S
R
T
V
N
G
S
R
L
V
Site 30
S247
A
S
R
T
V
N
G
S
R
L
V
P
Y
S
C
Site 31
Y252
N
G
S
R
L
V
P
Y
S
C
R
E
N
Y
S
Site 32
S253
G
S
R
L
V
P
Y
S
C
R
E
N
Y
S
D
Site 33
Y258
P
Y
S
C
R
E
N
Y
S
D
S
E
E
E
D
Site 34
S259
Y
S
C
R
E
N
Y
S
D
S
E
E
E
D
D
Site 35
S261
C
R
E
N
Y
S
D
S
E
E
E
D
D
D
D
Site 36
S271
E
D
D
D
D
V
A
S
S
R
Q
V
L
K
D
Site 37
S272
D
D
D
D
V
A
S
S
R
Q
V
L
K
D
D
Site 38
S280
R
Q
V
L
K
D
D
S
L
S
R
H
R
P
R
Site 39
S282
V
L
K
D
D
S
L
S
R
H
R
P
R
R
T
Site 40
T289
S
R
H
R
P
R
R
T
H
S
K
P
L
P
P
Site 41
S291
H
R
P
R
R
T
H
S
K
P
L
P
P
L
T
Site 42
T298
S
K
P
L
P
P
L
T
A
K
S
A
G
G
R
Site 43
S301
L
P
P
L
T
A
K
S
A
G
G
R
L
E
T
Site 44
T308
S
A
G
G
R
L
E
T
S
V
Q
G
G
G
G
Site 45
S309
A
G
G
R
L
E
T
S
V
Q
G
G
G
G
L
Site 46
S327
D
R
A
A
A
A
G
S
L
D
R
S
R
N
L
Site 47
S331
A
A
G
S
L
D
R
S
R
N
L
E
E
A
A
Site 48
S351
G
G
C
D
Q
V
D
S
S
P
V
P
R
Y
R
Site 49
S352
G
C
D
Q
V
D
S
S
P
V
P
R
Y
R
V
Site 50
Y357
D
S
S
P
V
P
R
Y
R
V
N
A
K
K
L
Site 51
T365
R
V
N
A
K
K
L
T
P
L
L
P
P
P
L
Site 52
T373
P
L
L
P
P
P
L
T
D
M
D
S
T
L
D
Site 53
S377
P
P
L
T
D
M
D
S
T
L
D
S
S
T
G
Site 54
T378
P
L
T
D
M
D
S
T
L
D
S
S
T
G
S
Site 55
S381
D
M
D
S
T
L
D
S
S
T
G
S
L
L
K
Site 56
S382
M
D
S
T
L
D
S
S
T
G
S
L
L
K
T
Site 57
S385
T
L
D
S
S
T
G
S
L
L
K
T
N
N
H
Site 58
T389
S
T
G
S
L
L
K
T
N
N
H
I
G
G
G
Site 59
S399
H
I
G
G
G
A
F
S
V
D
S
P
R
I
Y
Site 60
S402
G
G
A
F
S
V
D
S
P
R
I
Y
S
N
S
Site 61
Y406
S
V
D
S
P
R
I
Y
S
N
S
L
P
P
S
Site 62
S407
V
D
S
P
R
I
Y
S
N
S
L
P
P
S
A
Site 63
S409
S
P
R
I
Y
S
N
S
L
P
P
S
A
A
V
Site 64
S413
Y
S
N
S
L
P
P
S
A
A
V
A
A
S
S
Site 65
Y436
H
T
G
S
N
H
T
Y
L
K
N
T
Y
N
K
Site 66
Y441
H
T
Y
L
K
N
T
Y
N
K
P
K
L
S
E
Site 67
S447
T
Y
N
K
P
K
L
S
E
P
E
E
E
L
L
Site 68
S463
Q
F
K
R
E
E
V
S
P
T
G
S
F
S
A
Site 69
T465
K
R
E
E
V
S
P
T
G
S
F
S
A
H
Y
Site 70
S467
E
E
V
S
P
T
G
S
F
S
A
H
Y
L
S
Site 71
T498
T
Y
L
G
M
R
G
T
G
V
S
E
D
G
E
Site 72
S501
G
M
R
G
T
G
V
S
E
D
G
E
L
S
I
Site 73
S507
V
S
E
D
G
E
L
S
I
E
N
P
F
G
E
Site 74
T525
K
I
Q
E
S
E
K
T
L
M
M
N
T
L
Y
Site 75
T530
E
K
T
L
M
M
N
T
L
Y
K
L
H
D
R
Site 76
Y532
T
L
M
M
N
T
L
Y
K
L
H
D
R
L
A
Site 77
S549
A
G
D
H
E
C
G
S
S
S
Q
R
T
L
S
Site 78
S550
G
D
H
E
C
G
S
S
S
Q
R
T
L
S
V
Site 79
S551
D
H
E
C
G
S
S
S
Q
R
T
L
S
V
Q
Site 80
T554
C
G
S
S
S
Q
R
T
L
S
V
Q
E
A
A
Site 81
S556
S
S
S
Q
R
T
L
S
V
Q
E
A
A
A
Y
Site 82
Y563
S
V
Q
E
A
A
A
Y
L
K
D
L
G
P
E
Site 83
Y571
L
K
D
L
G
P
E
Y
E
G
I
F
N
T
S
Site 84
T603
F
G
P
E
E
E
L
T
N
I
T
D
V
Q
F
Site 85
S613
T
D
V
Q
F
L
Q
S
T
R
P
L
M
S
F
Site 86
Y651
M
V
C
V
V
L
R
Y
M
K
Y
R
W
T
K
Site 87
Y654
V
V
L
R
Y
M
K
Y
R
W
T
K
E
E
E
Site 88
T657
R
Y
M
K
Y
R
W
T
K
E
E
E
E
T
R
Site 89
Y667
E
E
E
T
R
Q
M
Y
D
M
V
V
K
I
I
Site 90
S679
K
I
I
D
V
L
R
S
H
N
E
A
C
Q
E
Site 91
Y693
E
N
K
D
L
Q
P
Y
M
P
I
P
H
V
R
Site 92
S702
P
I
P
H
V
R
D
S
L
I
Q
P
H
D
R
Site 93
S728
D
F
L
A
A
N
E
S
R
V
R
T
E
T
R
Site 94
T732
A
N
E
S
R
V
R
T
E
T
R
R
I
G
G
Site 95
T734
E
S
R
V
R
T
E
T
R
R
I
G
G
A
D
Site 96
S777
F
H
L
D
R
R
N
S
P
P
N
S
L
T
P
Site 97
S781
R
R
N
S
P
P
N
S
L
T
P
C
L
K
I
Site 98
T783
N
S
P
P
N
S
L
T
P
C
L
K
I
R
N
Site 99
S815
E
A
I
L
E
K
C
S
D
N
D
G
I
V
H
Site 100
Y835
N
S
R
E
G
C
V
Y
V
K
C
L
S
P
E
Site 101
Y843
V
K
C
L
S
P
E
Y
A
G
K
A
F
K
A
Site 102
T862
W
F
D
G
K
L
V
T
V
K
Y
L
R
L
D
Site 103
Y865
G
K
L
V
T
V
K
Y
L
R
L
D
R
Y
H
Site 104
Y871
K
Y
L
R
L
D
R
Y
H
H
R
F
P
Q
A
Site 105
S881
R
F
P
Q
A
L
T
S
N
T
P
L
K
P
S
Site 106
T883
P
Q
A
L
T
S
N
T
P
L
K
P
S
N
K
Site 107
S888
S
N
T
P
L
K
P
S
N
K
H
M
N
S
M
Site 108
S894
P
S
N
K
H
M
N
S
M
S
H
L
R
L
R
Site 109
S896
N
K
H
M
N
S
M
S
H
L
R
L
R
T
G
Site 110
T902
M
S
H
L
R
L
R
T
G
L
T
N
S
Q
G
Site 111
T905
L
R
L
R
T
G
L
T
N
S
Q
G
S
S
_
Site 112
S907
L
R
T
G
L
T
N
S
Q
G
S
S
_
_
_
Site 113
S910
G
L
T
N
S
Q
G
S
S
_
_
_
_
_
_
Site 114
S911
L
T
N
S
Q
G
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation