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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TrpC6
Full Name:
Short transient receptor potential channel 6
Alias:
Transient receptor potential cation channel, subfamily C, member 6; TRP6; TrpC6A
Type:
Channel protein
Mass (Da):
106326
Number AA:
931
UniProt ID:
Q9Y210
International Prot ID:
IPI00031683
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
F
G
P
R
R
G
S
S
P
R
G
A
A
G
Site 2
S14
F
G
P
R
R
G
S
S
P
R
G
A
A
G
A
Site 3
S28
A
A
A
R
R
N
E
S
Q
D
Y
L
L
M
D
Site 4
Y31
R
R
N
E
S
Q
D
Y
L
L
M
D
S
E
L
Site 5
Y51
P
Q
A
P
L
P
C
Y
G
Y
Y
P
C
F
R
Site 6
Y53
A
P
L
P
C
Y
G
Y
Y
P
C
F
R
G
S
Site 7
Y54
P
L
P
C
Y
G
Y
Y
P
C
F
R
G
S
D
Site 8
T70
R
L
A
H
R
R
Q
T
V
L
R
E
K
G
R
Site 9
Y86
L
A
N
R
G
P
A
Y
M
F
S
D
R
S
T
Site 10
S89
R
G
P
A
Y
M
F
S
D
R
S
T
S
L
S
Site 11
S92
A
Y
M
F
S
D
R
S
T
S
L
S
I
E
E
Site 12
T93
Y
M
F
S
D
R
S
T
S
L
S
I
E
E
E
Site 13
S94
M
F
S
D
R
S
T
S
L
S
I
E
E
E
R
Site 14
S96
S
D
R
S
T
S
L
S
I
E
E
E
R
F
L
Site 15
Y108
R
F
L
D
A
A
E
Y
G
N
I
P
V
V
R
Site 16
Y131
L
N
V
N
C
V
D
Y
M
G
Q
N
A
L
Q
Site 17
T194
A
E
G
K
R
L
A
T
S
P
S
Q
S
E
L
Site 18
S195
E
G
K
R
L
A
T
S
P
S
Q
S
E
L
Q
Site 19
S197
K
R
L
A
T
S
P
S
Q
S
E
L
Q
Q
D
Site 20
S199
L
A
T
S
P
S
Q
S
E
L
Q
Q
D
D
F
Site 21
Y207
E
L
Q
Q
D
D
F
Y
A
Y
D
E
D
G
T
Site 22
Y209
Q
Q
D
D
F
Y
A
Y
D
E
D
G
T
R
F
Site 23
S217
D
E
D
G
T
R
F
S
H
D
V
T
P
I
I
Site 24
T237
Q
E
Y
E
I
V
H
T
L
L
R
K
G
A
R
Site 25
S266
N
Q
K
Q
K
H
D
S
F
S
H
S
R
S
R
Site 26
S268
K
Q
K
H
D
S
F
S
H
S
R
S
R
I
N
Site 27
S270
K
H
D
S
F
S
H
S
R
S
R
I
N
A
Y
Site 28
S272
D
S
F
S
H
S
R
S
R
I
N
A
Y
K
G
Site 29
S282
N
A
Y
K
G
L
A
S
P
A
Y
L
S
L
S
Site 30
Y285
K
G
L
A
S
P
A
Y
L
S
L
S
S
E
D
Site 31
S289
S
P
A
Y
L
S
L
S
S
E
D
P
V
M
T
Site 32
S290
P
A
Y
L
S
L
S
S
E
D
P
V
M
T
A
Site 33
Y318
E
K
E
F
K
N
D
Y
K
K
L
S
M
Q
C
Site 34
S322
K
N
D
Y
K
K
L
S
M
Q
C
K
D
F
V
Site 35
T352
I
L
N
G
D
V
E
T
L
Q
S
G
D
H
G
Site 36
S364
D
H
G
R
P
N
L
S
R
L
K
L
A
I
K
Site 37
Y392
Q
Q
L
L
S
I
W
Y
E
N
L
S
G
L
R
Site 38
T515
A
E
C
K
E
I
W
T
Q
G
P
K
E
Y
L
Site 39
S556
W
H
A
S
K
A
Q
S
I
I
D
A
N
D
T
Site 40
T563
S
I
I
D
A
N
D
T
L
K
D
L
T
K
V
Site 41
T568
N
D
T
L
K
D
L
T
K
V
T
L
G
D
N
Site 42
Y578
T
L
G
D
N
V
K
Y
Y
N
L
A
R
I
K
Site 43
Y579
L
G
D
N
V
K
Y
Y
N
L
A
R
I
K
W
Site 44
S589
A
R
I
K
W
D
P
S
D
P
Q
I
I
S
E
Site 45
Y612
L
S
F
S
R
I
A
Y
I
L
P
A
N
E
S
Site 46
S626
S
F
G
P
L
Q
I
S
L
G
R
T
V
K
D
Site 47
T670
K
Q
N
E
A
F
T
T
V
E
E
S
F
K
T
Site 48
S730
L
I
A
M
I
N
S
S
F
Q
E
I
E
D
D
Site 49
S752
A
R
A
K
L
W
F
S
Y
F
E
E
G
R
T
Site 50
Y753
R
A
K
L
W
F
S
Y
F
E
E
G
R
T
L
Site 51
T759
S
Y
F
E
E
G
R
T
L
P
V
P
F
N
L
Site 52
S769
V
P
F
N
L
V
P
S
P
K
S
L
F
Y
L
Site 53
Y775
P
S
P
K
S
L
F
Y
L
L
L
K
L
K
K
Site 54
S785
L
K
L
K
K
W
I
S
E
L
F
Q
G
H
K
Site 55
S815
K
K
L
G
I
L
G
S
H
E
D
L
S
K
L
Site 56
S820
L
G
S
H
E
D
L
S
K
L
S
L
D
K
K
Site 57
S823
H
E
D
L
S
K
L
S
L
D
K
K
Q
V
G
Site 58
S836
V
G
H
N
K
Q
P
S
I
R
S
S
E
D
F
Site 59
S839
N
K
Q
P
S
I
R
S
S
E
D
F
H
L
N
Site 60
S840
K
Q
P
S
I
R
S
S
E
D
F
H
L
N
S
Site 61
S847
S
E
D
F
H
L
N
S
F
N
N
P
P
R
Q
Site 62
Y855
F
N
N
P
P
R
Q
Y
Q
K
I
M
K
R
L
Site 63
Y866
M
K
R
L
I
K
R
Y
V
L
Q
A
Q
I
D
Site 64
S876
Q
A
Q
I
D
K
E
S
D
E
V
N
E
G
E
Site 65
S893
E
I
K
Q
D
I
S
S
L
R
Y
E
L
L
E
Site 66
Y896
Q
D
I
S
S
L
R
Y
E
L
L
E
E
K
S
Site 67
S903
Y
E
L
L
E
E
K
S
Q
N
T
E
D
L
A
Site 68
S921
R
E
L
G
E
K
L
S
M
E
P
N
Q
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation