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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAPK8IP1
Full Name:
C-jun-amino-terminal kinase-interacting protein 1
Alias:
Islet-brain 1;JNK MAP kinase scaffold protein 1;Mitogen-activated protein kinase 8-interacting protein 1
Type:
Adapter/scaffold protein
Mass (Da):
77524
Number AA:
711
UniProt ID:
Q9UQF2
International Prot ID:
IPI00023133
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005078
GO:0019894
GO:0004860
PhosphoSite+
KinaseNET
Biological Process:
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
E
R
E
S
G
G
L
G
G
G
A
Site 2
S15
G
L
G
G
G
A
A
S
P
P
A
A
S
P
F
Site 3
S29
F
L
G
L
H
I
A
S
P
P
N
F
R
L
T
Site 4
T36
S
P
P
N
F
R
L
T
H
D
I
S
L
E
E
Site 5
S40
F
R
L
T
H
D
I
S
L
E
E
F
E
D
E
Site 6
S50
E
F
E
D
E
D
L
S
E
I
T
D
E
C
G
Site 7
T65
I
S
L
Q
C
K
D
T
L
S
L
R
P
P
R
Site 8
S67
L
Q
C
K
D
T
L
S
L
R
P
P
R
A
G
Site 9
S85
A
G
G
G
G
A
G
S
R
L
Q
A
E
M
L
Site 10
T100
Q
M
D
L
I
D
A
T
G
D
T
P
G
A
E
Site 11
T103
L
I
D
A
T
G
D
T
P
G
A
E
D
D
E
Site 12
S131
A
G
P
P
K
A
E
S
G
Q
E
P
A
S
R
Site 13
S137
E
S
G
Q
E
P
A
S
R
G
Q
G
Q
S
Q
Site 14
S143
A
S
R
G
Q
G
Q
S
Q
G
Q
S
Q
G
P
Site 15
S147
Q
G
Q
S
Q
G
Q
S
Q
G
P
G
S
G
D
Site 16
S152
G
Q
S
Q
G
P
G
S
G
D
T
Y
R
P
K
Site 17
T155
Q
G
P
G
S
G
D
T
Y
R
P
K
R
P
T
Site 18
Y156
G
P
G
S
G
D
T
Y
R
P
K
R
P
T
T
Site 19
T162
T
Y
R
P
K
R
P
T
T
L
N
L
F
P
Q
Site 20
T163
Y
R
P
K
R
P
T
T
L
N
L
F
P
Q
V
Site 21
S173
L
F
P
Q
V
P
R
S
Q
D
T
L
N
N
N
Site 22
T176
Q
V
P
R
S
Q
D
T
L
N
N
N
S
L
G
Site 23
S181
Q
D
T
L
N
N
N
S
L
G
K
K
H
S
W
Site 24
S187
N
S
L
G
K
K
H
S
W
Q
D
R
V
S
R
Site 25
S193
H
S
W
Q
D
R
V
S
R
S
S
S
P
L
K
Site 26
S195
W
Q
D
R
V
S
R
S
S
S
P
L
K
T
G
Site 27
S196
Q
D
R
V
S
R
S
S
S
P
L
K
T
G
E
Site 28
S197
D
R
V
S
R
S
S
S
P
L
K
T
G
E
Q
Site 29
T201
R
S
S
S
P
L
K
T
G
E
Q
T
P
P
H
Site 30
T205
P
L
K
T
G
E
Q
T
P
P
H
E
H
I
C
Site 31
S214
P
H
E
H
I
C
L
S
D
E
L
P
P
Q
S
Site 32
S221
S
D
E
L
P
P
Q
S
G
P
A
P
T
T
D
Site 33
T227
Q
S
G
P
A
P
T
T
D
R
G
T
S
T
D
Site 34
T231
A
P
T
T
D
R
G
T
S
T
D
S
P
C
R
Site 35
S232
P
T
T
D
R
G
T
S
T
D
S
P
C
R
R
Site 36
T233
T
T
D
R
G
T
S
T
D
S
P
C
R
R
S
Site 37
S235
D
R
G
T
S
T
D
S
P
C
R
R
S
T
A
Site 38
S240
T
D
S
P
C
R
R
S
T
A
T
Q
M
A
P
Site 39
T241
D
S
P
C
R
R
S
T
A
T
Q
M
A
P
P
Site 40
T243
P
C
R
R
S
T
A
T
Q
M
A
P
P
G
G
Site 41
S262
P
P
G
G
R
G
H
S
H
R
D
R
I
H
Y
Site 42
Y269
S
H
R
D
R
I
H
Y
Q
A
D
V
R
L
E
Site 43
Y282
L
E
A
T
E
E
I
Y
L
T
P
V
Q
R
P
Site 44
T284
A
T
E
E
I
Y
L
T
P
V
Q
R
P
P
D
Site 45
S297
P
D
A
A
E
P
T
S
A
F
L
P
P
T
E
Site 46
T303
T
S
A
F
L
P
P
T
E
S
R
M
S
V
S
Site 47
S305
A
F
L
P
P
T
E
S
R
M
S
V
S
S
D
Site 48
S308
P
P
T
E
S
R
M
S
V
S
S
D
P
D
P
Site 49
S310
T
E
S
R
M
S
V
S
S
D
P
D
P
A
A
Site 50
S311
E
S
R
M
S
V
S
S
D
P
D
P
A
A
Y
Site 51
Y318
S
D
P
D
P
A
A
Y
P
S
T
A
G
R
P
Site 52
S320
P
D
P
A
A
Y
P
S
T
A
G
R
P
H
P
Site 53
S328
T
A
G
R
P
H
P
S
I
S
E
E
E
E
G
Site 54
S330
G
R
P
H
P
S
I
S
E
E
E
E
G
F
D
Site 55
S340
E
E
G
F
D
C
L
S
S
P
E
R
A
E
P
Site 56
S341
E
G
F
D
C
L
S
S
P
E
R
A
E
P
P
Site 57
S355
P
G
G
G
W
R
G
S
L
G
E
P
P
P
P
Site 58
S366
P
P
P
P
P
R
A
S
L
S
S
D
T
S
A
Site 59
S368
P
P
P
R
A
S
L
S
S
D
T
S
A
L
S
Site 60
S369
P
P
R
A
S
L
S
S
D
T
S
A
L
S
Y
Site 61
T371
R
A
S
L
S
S
D
T
S
A
L
S
Y
D
S
Site 62
S372
A
S
L
S
S
D
T
S
A
L
S
Y
D
S
V
Site 63
S375
S
S
D
T
S
A
L
S
Y
D
S
V
K
Y
T
Site 64
Y376
S
D
T
S
A
L
S
Y
D
S
V
K
Y
T
L
Site 65
T382
S
Y
D
S
V
K
Y
T
L
V
V
D
E
H
A
Site 66
Y403
L
R
P
C
F
G
D
Y
S
D
E
S
D
S
A
Site 67
S404
R
P
C
F
G
D
Y
S
D
E
S
D
S
A
T
Site 68
S407
F
G
D
Y
S
D
E
S
D
S
A
T
V
Y
D
Site 69
S409
D
Y
S
D
E
S
D
S
A
T
V
Y
D
N
C
Site 70
T411
S
D
E
S
D
S
A
T
V
Y
D
N
C
A
S
Site 71
Y413
E
S
D
S
A
T
V
Y
D
N
C
A
S
V
S
Site 72
S418
T
V
Y
D
N
C
A
S
V
S
S
P
Y
E
S
Site 73
S420
Y
D
N
C
A
S
V
S
S
P
Y
E
S
A
I
Site 74
S421
D
N
C
A
S
V
S
S
P
Y
E
S
A
I
G
Site 75
S425
S
V
S
S
P
Y
E
S
A
I
G
E
E
Y
E
Site 76
S444
P
Q
P
P
A
C
L
S
E
D
S
T
P
D
E
Site 77
S447
P
A
C
L
S
E
D
S
T
P
D
E
P
D
V
Site 78
T448
A
C
L
S
E
D
S
T
P
D
E
P
D
V
H
Site 79
S466
K
F
L
N
V
F
M
S
G
R
S
R
S
S
S
Site 80
S469
N
V
F
M
S
G
R
S
R
S
S
S
A
E
S
Site 81
S471
F
M
S
G
R
S
R
S
S
S
A
E
S
F
G
Site 82
S472
M
S
G
R
S
R
S
S
S
A
E
S
F
G
L
Site 83
S473
S
G
R
S
R
S
S
S
A
E
S
F
G
L
F
Site 84
S476
S
R
S
S
S
A
E
S
F
G
L
F
S
C
I
Site 85
T492
N
G
E
E
Q
E
Q
T
H
R
A
I
F
R
F
Site 86
Y524
V
E
L
Q
A
E
D
Y
W
Y
E
A
Y
N
M
Site 87
Y526
L
Q
A
E
D
Y
W
Y
E
A
Y
N
M
R
T
Site 88
Y529
E
D
Y
W
Y
E
A
Y
N
M
R
T
G
A
R
Site 89
Y543
R
G
V
F
P
A
Y
Y
A
I
E
V
T
K
E
Site 90
S574
F
R
V
K
F
L
G
S
V
Q
V
P
Y
H
K
Site 91
Y579
L
G
S
V
Q
V
P
Y
H
K
G
N
D
V
L
Site 92
T595
A
A
M
Q
K
I
A
T
T
R
R
L
T
V
H
Site 93
T596
A
M
Q
K
I
A
T
T
R
R
L
T
V
H
F
Site 94
T600
I
A
T
T
R
R
L
T
V
H
F
N
P
P
S
Site 95
S627
I
G
V
K
A
D
D
S
Q
E
A
K
G
N
K
Site 96
Y649
K
N
I
S
F
C
G
Y
H
P
K
N
N
K
Y
Site 97
Y656
Y
H
P
K
N
N
K
Y
F
G
F
I
T
K
H
Site 98
S686
S
T
K
A
L
A
E
S
V
G
R
A
F
Q
Q
Site 99
Y701
F
Y
K
Q
F
V
E
Y
T
C
P
T
E
D
I
Site 100
T702
Y
K
Q
F
V
E
Y
T
C
P
T
E
D
I
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation