PhosphoNET

           
Protein Info 
   
Short Name:  SETD1B
Full Name:  Histone-lysine N-methyltransferase SET domain-containing protein 1B
Alias:  FLJ20803; KIAA1076; KMT2G; Lysine N-methyltransferase 2G; SET domain containing 1B; SET1B
Type:  Amino Acid Metabolism - lysine degradation; Methyltransferase; EC 2.1.1.43
Mass (Da):  208732
Number AA:  1923
UniProt ID:  Q9UPS6
International Prot ID:  not found
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0035097  GO:0016607   Uniprot OncoNet
Molecular Function:  GO:0003723  GO:0018024  GO:0000166 PhosphoSite+ KinaseNET
Biological Process:  GO:0051568  GO:0045449  GO:0006350 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S21PPPQPGPSGERRNHH
Site 2Y32RNHHWRSYKLMIDPA
Site 3Y48KKGHHKLYRYDGQHF
Site 4Y50GHHKLYRYDGQHFSL
Site 5S56RYDGQHFSLAMSSNR
Site 6S60QHFSLAMSSNRPVEI
Site 7T78PRVVGIWTKNKELEL
Site 8S86KNKELELSVPKFKID
Site 9Y96KFKIDEFYVGPVPPK
Site 10T106PVPPKQVTFAKLNDN
Site 11Y126LRDMCKKYGEVEEVE
Site 12Y136VEEVEILYNPKTKKH
Site 13T140EILYNPKTKKHLGIA
Site 14Y189GETRMRFYELLVTGR
Site 15T194RFYELLVTGRYTPQT
Site 16T201TGRYTPQTLPVGELD
Site 17S211VGELDAVSPIVNETL
Site 18S221VNETLQLSDALKRLK
Site 19S233RLKDGGLSAGCGSGS
Site 20S238GLSAGCGSGSSSVTP
Site 21S240SAGCGSGSSSVTPNS
Site 22S241AGCGSGSSSVTPNSG
Site 23S242GCGSGSSSVTPNSGG
Site 24T244GSGSSSVTPNSGGTP
Site 25S247SSSVTPNSGGTPFSQ
Site 26T250VTPNSGGTPFSQDTA
Site 27S253NSGGTPFSQDTAYSS
Site 28T256GTPFSQDTAYSSCRL
Site 29Y258PFSQDTAYSSCRLDT
Site 30S259FSQDTAYSSCRLDTP
Site 31S260SQDTAYSSCRLDTPN
Site 32T265YSSCRLDTPNSYGQG
Site 33S268CRLDTPNSYGQGTPL
Site 34Y269RLDTPNSYGQGTPLT
Site 35T273PNSYGQGTPLTPRLG
Site 36T276YGQGTPLTPRLGTPF
Site 37T281PLTPRLGTPFSQDSS
Site 38S284PRLGTPFSQDSSYSS
Site 39S287GTPFSQDSSYSSRQP
Site 40S288TPFSQDSSYSSRQPT
Site 41Y289PFSQDSSYSSRQPTP
Site 42S290FSQDSSYSSRQPTPS
Site 43S291SQDSSYSSRQPTPSY
Site 44T295SYSSRQPTPSYLFSQ
Site 45S297SSRQPTPSYLFSQDP
Site 46Y298SRQPTPSYLFSQDPA
Site 47S301PTPSYLFSQDPAVTF
Site 48T307FSQDPAVTFKARRHE
Site 49S315FKARRHESKFTDAYN
Site 50T318RRHESKFTDAYNRRH
Site 51Y321ESKFTDAYNRRHEHH
Site 52Y329NRRHEHHYVHNSPAV
Site 53S333EHHYVHNSPAVTAVA
Site 54T360PFGAVGGTGGSSGPP
Site 55S364VGGTGGSSGPPFKAQ
Site 56S375FKAQPQDSATFAHTP
Site 57T377AQPQDSATFAHTPPP
Site 58T381DSATFAHTPPPAQAT
Site 59T388TPPPAQATPAPGFKS
Site 60S395TPAPGFKSAFSPYQT
Site 61S398PGFKSAFSPYQTPVA
Site 62Y400FKSAFSPYQTPVAHF
Site 63T402SAFSPYQTPVAHFPP
Site 64T417PPEEPTATAAFGARD
Site 65S425AAFGARDSGEFRRAP
Site 66T450LAKEKPGTPPGPPPP
Site 67T459PGPPPPDTNSMELGG
Site 68S461PPPPDTNSMELGGRP
Site 69T469MELGGRPTFGWSPEP
Site 70S473GRPTFGWSPEPCDSP
Site 71S479WSPEPCDSPGTPTLE
Site 72T482EPCDSPGTPTLESSP
Site 73T484CDSPGTPTLESSPAG
Site 74S487PGTPTLESSPAGPEK
Site 75S488GTPTLESSPAGPEKP
Site 76S498GPEKPHDSLDSRIEM
Site 77S501PAGSPELSPPQPLFR
Site 78S522LFLREPDSDTELQME
Site 79T524LREPDSDTELQMEGS
Site 80S531TELQMEGSPISSSSS
Site 81S534QMEGSPISSSSSQLS
Site 82S535MEGSPISSSSSQLSP
Site 83S536EGSPISSSSSQLSPL
Site 84S537GSPISSSSSQLSPLA
Site 85S538SPISSSSSQLSPLAP
Site 86S541SSSSSQLSPLAPFGT
Site 87T548SPLAPFGTNSQPGFR
Site 88S550LAPFGTNSQPGFRGP
Site 89T558QPGFRGPTPPSSRPS
Site 90S561FRGPTPPSSRPSSTG
Site 91S562RGPTPPSSRPSSTGL
Site 92S565TPPSSRPSSTGLEDI
Site 93S566PPSSRPSSTGLEDIS
Site 94S573STGLEDISPTPLPDS
Site 95T575GLEDISPTPLPDSDE
Site 96S580SPTPLPDSDEDEELD
Site 97T622LDLVGDRTPTSEKMD
Site 98T624LVGDRTPTSEKMDEG
Site 99S625VGDRTPTSEKMDEGQ
Site 100S634KMDEGQQSSGEDMEI
Site 101S642SGEDMEISDDEMPSA
Site 102S648ISDDEMPSAPITSAD
Site 103T652EMPSAPITSADCPKP
Site 104T724PPAHPAVTVPPPPLP
Site 105T779PMSFQMQTQVLSRLM
Site 106S783QMQTQVLSRLMTGQG
Site 107T787QVLSRLMTGQGACPY
Site 108Y817QFVNLPPYRGPFSLS
Site 109S822PPYRGPFSLSNSGPG
Site 110S824YRGPFSLSNSGPGRG
Site 111S826GPFSLSNSGPGRGQH
Site 112S843PLPKFDPSVPPPGYM
Site 113Y849PSVPPPGYMPRQEDP
Site 114S907KERMAKASLTPVKSG
Site 115T909RMAKASLTPVKSGEH
Site 116S913ASLTPVKSGEHKDED
Site 117S930KPKDRIASCLLESWG
Site 118S961RGAIRLPSFKVKRKE
Site 119T972KRKEPPDTTSSGDQK
Site 120T973RKEPPDTTSSGDQKR
Site 121S974KEPPDTTSSGDQKRL
Site 122S975EPPDTTSSGDQKRLR
Site 123S984DQKRLRPSTSVDEED
Site 124T985QKRLRPSTSVDEEDE
Site 125S986KRLRPSTSVDEEDEE
Site 126S994VDEEDEESERERDRD
Site 127T1005RDRDMADTPCELAKR
Site 128S1031ARPLELDSGGEEDEK
Site 129S1040GEEDEKESLSEEQES
Site 130S1042EDEKESLSEEQESTE
Site 131S1047SLSEEQESTEEEEEA
Site 132T1048LSEEQESTEEEEEAE
Site 133S1068EDDDDDDSDDRDESE
Site 134S1074DSDDRDESENDDEDT
Site 135T1081SENDDEDTALSEASE
Site 136S1084DDEDTALSEASEKDE
Site 137S1094SEKDEGDSDEEETVS
Site 138T1099GDSDEEETVSIVTSK
Site 139S1101SDEEETVSIVTSKAE
Site 140S1105ETVSIVTSKAEATSS
Site 141S1111TSKAEATSSSESSES
Site 142S1112SKAEATSSSESSESS
Site 143S1113KAEATSSSESSESSE
Site 144S1115EATSSSESSESSEFE
Site 145S1116ATSSSESSESSEFES
Site 146S1118SSSESSESSEFESSS
Site 147S1119SSESSESSEFESSSE
Site 148S1123SESSEFESSSESSPS
Site 149S1124ESSEFESSSESSPSS
Site 150S1125SSEFESSSESSPSSS
Site 151S1127EFESSSESSPSSSED
Site 152S1128FESSSESSPSSSEDE
Site 153S1130SSSESSPSSSEDEEE
Site 154S1131SSESSPSSSEDEEEV
Site 155S1132SESSPSSSEDEEEVV
Site 156S1160VAEESMASAGPEDFE
Site 157S1184PGAPAVDSLGMEEEV
Site 158T1195EEEVDIETEAVAPEE
Site 159S1205VAPEERPSMLDEPPL
Site 160S1222GVEEPADSREPPEEP
Site 161S1232PPEEPGLSQEGAMLL
Site 162S1240QEGAMLLSPEPPAKE
Site 163S1255VEARPPLSPERAPEH
Site 164S1292PRPPRPPSPPPEPET
Site 165T1299SPPPEPETTDASHPS
Site 166T1300PPPEPETTDASHPSV
Site 167S1303EPETTDASHPSVPPE
Site 168S1306TTDASHPSVPPEPLA
Site 169T1320AEDHPPHTPGLCGSL
Site 170S1326HTPGLCGSLAKSQST
Site 171S1330LCGSLAKSQSTETVP
Site 172S1332GSLAKSQSTETVPAT
Site 173T1335AKSQSTETVPATPGG
Site 174T1339STETVPATPGGEPPL
Site 175S1347PGGEPPLSGGSSGLS
Site 176S1350EPPLSGGSSGLSLSS
Site 177S1351PPLSGGSSGLSLSSP
Site 178S1354SGGSSGLSLSSPQVP
Site 179S1356GSSGLSLSSPQVPGS
Site 180S1357SSGLSLSSPQVPGSP
Site 181S1363SSPQVPGSPFSYPAP
Site 182S1366QVPGSPFSYPAPSPS
Site 183Y1367VPGSPFSYPAPSPSL
Site 184S1371PFSYPAPSPSLSSGG
Site 185S1373SYPAPSPSLSSGGLP
Site 186S1375PAPSPSLSSGGLPRT
Site 187T1382SSGGLPRTPGRDFSF
Site 188S1388RTPGRDFSFTPTFSE
Site 189T1390PGRDFSFTPTFSEPS
Site 190T1392RDFSFTPTFSEPSGP
Site 191T1409LPVCPLPTGRRDERS
Site 192S1416TGRRDERSGPLASPV
Site 193S1421ERSGPLASPVLLETG
Site 194T1455RAQARAPTPLPPLLP
Site 195S1482KPGRPRRSPPSMLSL
Site 196S1485RPRRSPPSMLSLDGP
Site 197S1488RSPPSMLSLDGPLVR
Site 198T1515LLPGQPQTPVFPSTH
Site 199S1520PQTPVFPSTHDPRTV
Site 200T1521QTPVFPSTHDPRTVT
Site 201T1526PSTHDPRTVTLDFRN
Site 202T1528THDPRTVTLDFRNAG
Site 203T1559PPPPVEPTKLPFKEL
Site 204S1572ELDNQWPSEAIPPGP
Site 205T1586PRGRDEVTEEYMELA
Site 206Y1589RDEVTEEYMELAKSR
Site 207S1595EYMELAKSRGPWRRP
Site 208S1616DLVPPAGSPELSPPQ
Site 209S1620PAGSPELSPPQPLFR
Site 210S1630QPLFRPRSEFEEMTI
Site 211T1657DIRFLCVTYERLLQQ
Site 212Y1658IRFLCVTYERLLQQD
Site 213Y1678LNDTLWVYHPSTSLS
Site 214S1681TLWVYHPSTSLSSAK
Site 215T1682LWVYHPSTSLSSAKK
Site 216S1683WVYHPSTSLSSAKKK
Site 217S1685YHPSTSLSSAKKKKR
Site 218T1701DGIREHVTGCARSEG
Site 219Y1710CARSEGFYTIDKKDK
Site 220T1711ARSEGFYTIDKKDKL
Site 221Y1720DKKDKLRYLNSSRAS
Site 222S1723DKLRYLNSSRASTDE
Site 223S1724KLRYLNSSRASTDEP
Site 224S1727YLNSSRASTDEPPAD
Site 225T1728LNSSRASTDEPPADT
Site 226T1735TDEPPADTQGMSIPA
Site 227S1739PADTQGMSIPAQPHA
Site 228S1747IPAQPHASTRAGSER
Site 229S1752HASTRAGSERRSEQR
Site 230S1756RAGSERRSEQRRLLS
Site 231S1763SEQRRLLSSFTGSCD
Site 232S1764EQRRLLSSFTGSCDS
Site 233T1766RRLLSSFTGSCDSDL
Site 234S1771SFTGSCDSDLLKFNQ
Site 235Y1813ADEMVIEYVGQNIRQ
Site 236Y1830ADMREKRYEDEGIGS
Site 237S1837YEDEGIGSSYMFRVD
Site 238S1838EDEGIGSSYMFRVDH
Site 239Y1839DEGIGSSYMFRVDHD
Site 240T1847MFRVDHDTIIDATKC
Site 241Y1898NVNEEITYDYKFPIE
Site 242Y1900NEEITYDYKFPIEDV
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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