KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PHF8
Full Name:
ISOFORM 3 OF PHD FINGER PROTEIN 8.
Alias:
JHDM1F; jumonji C domain-containing histone demethylase 1F; KIAA1111; PHD finger protein 8; ZNF422
Type:
Demethylase
Mass (Da):
117864
Number AA:
1060
UniProt ID:
Q9UPP1
International Prot ID:
IPI00480187
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
P
P
P
A
P
L
D
T
T
N
L
A
G
R
R
Site 2
T23
P
P
A
P
L
D
T
T
N
L
A
G
R
R
T
Site 3
T30
T
N
L
A
G
R
R
T
L
Q
G
R
A
K
M
Site 4
S69
C
Q
D
W
F
H
G
S
C
V
G
V
E
E
E
Site 5
Y84
K
A
A
D
I
D
L
Y
H
C
P
N
C
E
V
Site 6
S104
I
M
K
K
R
R
G
S
S
K
G
H
D
T
H
Site 7
S105
M
K
K
R
R
G
S
S
K
G
H
D
T
H
K
Site 8
T110
G
S
S
K
G
H
D
T
H
K
G
K
P
V
K
Site 9
T118
H
K
G
K
P
V
K
T
G
S
P
T
F
V
R
Site 10
S120
G
K
P
V
K
T
G
S
P
T
F
V
R
E
L
Site 11
T122
P
V
K
T
G
S
P
T
F
V
R
E
L
R
S
Site 12
S129
T
F
V
R
E
L
R
S
R
T
F
D
S
S
D
Site 13
T131
V
R
E
L
R
S
R
T
F
D
S
S
D
E
V
Site 14
S134
L
R
S
R
T
F
D
S
S
D
E
V
I
L
K
Site 15
S135
R
S
R
T
F
D
S
S
D
E
V
I
L
K
P
Site 16
T148
K
P
T
G
N
Q
L
T
V
E
F
L
E
E
N
Site 17
T172
K
K
D
G
L
G
M
T
L
P
S
P
S
F
T
Site 18
S175
G
L
G
M
T
L
P
S
P
S
F
T
V
R
D
Site 19
S177
G
M
T
L
P
S
P
S
F
T
V
R
D
V
E
Site 20
T179
T
L
P
S
P
S
F
T
V
R
D
V
E
H
Y
Site 21
Y186
T
V
R
D
V
E
H
Y
V
G
S
D
K
E
I
Site 22
Y214
K
L
G
D
F
V
K
Y
Y
Y
S
G
K
R
E
Site 23
Y215
L
G
D
F
V
K
Y
Y
Y
S
G
K
R
E
K
Site 24
Y216
G
D
F
V
K
Y
Y
Y
S
G
K
R
E
K
V
Site 25
S217
D
F
V
K
Y
Y
Y
S
G
K
R
E
K
V
L
Site 26
S228
E
K
V
L
N
V
I
S
L
E
F
S
D
T
R
Site 27
S232
N
V
I
S
L
E
F
S
D
T
R
L
S
N
L
Site 28
T234
I
S
L
E
F
S
D
T
R
L
S
N
L
V
E
Site 29
S237
E
F
S
D
T
R
L
S
N
L
V
E
T
P
K
Site 30
T242
R
L
S
N
L
V
E
T
P
K
I
V
R
K
L
Site 31
S250
P
K
I
V
R
K
L
S
W
V
E
N
L
W
P
Site 32
Y270
E
R
P
N
V
Q
K
Y
C
L
M
S
V
R
D
Site 33
Y279
L
M
S
V
R
D
S
Y
T
D
F
H
I
D
F
Site 34
Y293
F
G
G
T
S
V
W
Y
H
V
L
K
G
E
K
Site 35
Y303
L
K
G
E
K
I
F
Y
L
I
R
P
T
N
A
Site 36
T313
R
P
T
N
A
N
L
T
L
F
E
C
W
S
S
Site 37
S319
L
T
L
F
E
C
W
S
S
S
S
N
Q
N
E
Site 38
Y337
G
D
Q
V
D
K
C
Y
K
C
S
V
K
Q
G
Site 39
S390
Y
E
I
E
K
R
L
S
T
A
D
L
F
R
F
Site 40
T391
E
I
E
K
R
L
S
T
A
D
L
F
R
F
P
Site 41
S427
E
N
R
R
H
P
A
S
Y
L
V
H
G
G
K
Site 42
Y428
N
R
R
H
P
A
S
Y
L
V
H
G
G
K
A
Site 43
T444
N
L
A
F
R
A
W
T
R
K
E
A
L
P
D
Site 44
T459
H
E
D
E
I
P
E
T
V
R
T
V
Q
L
I
Site 45
T462
E
I
P
E
T
V
R
T
V
Q
L
I
K
D
L
Site 46
T505
P
A
G
S
I
P
L
T
R
P
A
H
S
T
S
Site 47
S510
P
L
T
R
P
A
H
S
T
S
V
S
M
S
R
Site 48
T511
L
T
R
P
A
H
S
T
S
V
S
M
S
R
L
Site 49
S512
T
R
P
A
H
S
T
S
V
S
M
S
R
L
S
Site 50
S514
P
A
H
S
T
S
V
S
M
S
R
L
S
L
P
Site 51
S516
H
S
T
S
V
S
M
S
R
L
S
L
P
S
K
Site 52
S519
S
V
S
M
S
R
L
S
L
P
S
K
N
G
S
Site 53
S522
M
S
R
L
S
L
P
S
K
N
G
S
K
K
K
Site 54
S526
S
L
P
S
K
N
G
S
K
K
K
G
L
K
P
Site 55
S547
A
E
R
K
G
K
E
S
S
A
L
G
P
A
G
Site 56
S557
L
G
P
A
G
Q
L
S
Y
N
L
M
D
T
Y
Site 57
T563
L
S
Y
N
L
M
D
T
Y
S
H
Q
A
L
K
Site 58
Y564
S
Y
N
L
M
D
T
Y
S
H
Q
A
L
K
T
Site 59
T571
Y
S
H
Q
A
L
K
T
G
S
F
Q
K
A
K
Site 60
S573
H
Q
A
L
K
T
G
S
F
Q
K
A
K
F
N
Site 61
S589
T
G
A
C
L
N
D
S
D
D
D
S
P
D
L
Site 62
S593
L
N
D
S
D
D
D
S
P
D
L
D
L
D
G
Site 63
S610
S
P
L
A
L
L
M
S
N
G
S
T
K
R
V
Site 64
S613
A
L
L
M
S
N
G
S
T
K
R
V
K
S
L
Site 65
T614
L
L
M
S
N
G
S
T
K
R
V
K
S
L
S
Site 66
S619
G
S
T
K
R
V
K
S
L
S
K
S
R
R
T
Site 67
S621
T
K
R
V
K
S
L
S
K
S
R
R
T
K
I
Site 68
S623
R
V
K
S
L
S
K
S
R
R
T
K
I
A
K
Site 69
T626
S
L
S
K
S
R
R
T
K
I
A
K
K
V
D
Site 70
S651
E
D
E
F
D
L
D
S
D
D
E
L
Q
I
D
Site 71
S685
L
P
R
A
K
P
C
S
D
P
N
R
V
R
E
Site 72
Y704
E
F
D
I
E
E
D
Y
T
T
D
E
D
M
V
Site 73
T705
F
D
I
E
E
D
Y
T
T
D
E
D
M
V
E
Site 74
T706
D
I
E
E
D
Y
T
T
D
E
D
M
V
E
G
Site 75
S722
E
G
K
L
G
N
G
S
G
A
G
G
I
L
D
Site 76
Y742
R
Q
V
G
G
P
D
Y
A
A
L
T
E
A
P
Site 77
T746
G
P
D
Y
A
A
L
T
E
A
P
A
S
P
S
Site 78
S751
A
L
T
E
A
P
A
S
P
S
T
Q
E
A
I
Site 79
S769
L
C
M
A
N
L
Q
S
S
S
S
S
P
A
T
Site 80
S770
C
M
A
N
L
Q
S
S
S
S
S
P
A
T
S
Site 81
S771
M
A
N
L
Q
S
S
S
S
S
P
A
T
S
S
Site 82
S772
A
N
L
Q
S
S
S
S
S
P
A
T
S
S
L
Site 83
S773
N
L
Q
S
S
S
S
S
P
A
T
S
S
L
Q
Site 84
T776
S
S
S
S
S
P
A
T
S
S
L
Q
A
W
W
Site 85
S777
S
S
S
S
P
A
T
S
S
L
Q
A
W
W
T
Site 86
S778
S
S
S
P
A
T
S
S
L
Q
A
W
W
T
G
Site 87
T784
S
S
L
Q
A
W
W
T
G
G
Q
D
R
S
S
Site 88
S790
W
T
G
G
Q
D
R
S
S
G
S
S
S
S
G
Site 89
S791
T
G
G
Q
D
R
S
S
G
S
S
S
S
G
L
Site 90
S793
G
Q
D
R
S
S
G
S
S
S
S
G
L
G
T
Site 91
S794
Q
D
R
S
S
G
S
S
S
S
G
L
G
T
V
Site 92
S795
D
R
S
S
G
S
S
S
S
G
L
G
T
V
S
Site 93
S796
R
S
S
G
S
S
S
S
G
L
G
T
V
S
N
Site 94
T800
S
S
S
S
G
L
G
T
V
S
N
S
P
A
S
Site 95
S802
S
S
G
L
G
T
V
S
N
S
P
A
S
Q
R
Site 96
S804
G
L
G
T
V
S
N
S
P
A
S
Q
R
T
P
Site 97
S807
T
V
S
N
S
P
A
S
Q
R
T
P
G
K
R
Site 98
T810
N
S
P
A
S
Q
R
T
P
G
K
R
P
I
K
Site 99
Y821
R
P
I
K
R
P
A
Y
W
R
T
E
S
E
E
Site 100
S826
P
A
Y
W
R
T
E
S
E
E
E
E
E
N
A
Site 101
S834
E
E
E
E
E
N
A
S
L
D
E
Q
D
S
L
Site 102
S840
A
S
L
D
E
Q
D
S
L
G
A
C
F
K
D
Site 103
Y850
A
C
F
K
D
A
E
Y
I
Y
P
S
L
E
S
Site 104
Y852
F
K
D
A
E
Y
I
Y
P
S
L
E
S
D
D
Site 105
S854
D
A
E
Y
I
Y
P
S
L
E
S
D
D
D
D
Site 106
S857
Y
I
Y
P
S
L
E
S
D
D
D
D
P
A
L
Site 107
S866
D
D
D
P
A
L
K
S
R
P
K
K
K
K
N
Site 108
S874
R
P
K
K
K
K
N
S
D
D
A
P
W
S
P
Site 109
S880
N
S
D
D
A
P
W
S
P
K
A
R
V
T
P
Site 110
T886
W
S
P
K
A
R
V
T
P
T
L
P
K
Q
D
Site 111
T900
D
R
P
V
R
E
G
T
R
V
A
S
I
E
T
Site 112
S904
R
E
G
T
R
V
A
S
I
E
T
G
L
A
A
Site 113
T907
T
R
V
A
S
I
E
T
G
L
A
A
A
A
A
Site 114
Y929
Q
K
A
Q
K
K
K
Y
I
K
K
K
P
L
L
Site 115
S947
E
Q
P
R
P
Q
D
S
N
L
S
L
T
V
P
Site 116
S950
R
P
Q
D
S
N
L
S
L
T
V
P
A
P
T
Site 117
S967
A
T
P
Q
L
V
T
S
S
S
P
L
P
P
P
Site 118
S969
P
Q
L
V
T
S
S
S
P
L
P
P
P
E
P
Site 119
S982
E
P
K
Q
E
A
L
S
G
S
L
A
D
H
E
Site 120
S984
K
Q
E
A
L
S
G
S
L
A
D
H
E
Y
T
Site 121
Y990
G
S
L
A
D
H
E
Y
T
A
R
P
N
A
F
Site 122
T991
S
L
A
D
H
E
Y
T
A
R
P
N
A
F
G
Site 123
S1005
G
M
A
Q
A
N
R
S
T
T
P
M
A
P
G
Site 124
T1006
M
A
Q
A
N
R
S
T
T
P
M
A
P
G
V
Site 125
T1007
A
Q
A
N
R
S
T
T
P
M
A
P
G
V
F
Site 126
T1016
M
A
P
G
V
F
L
T
Q
R
R
P
S
V
G
Site 127
S1021
F
L
T
Q
R
R
P
S
V
G
S
Q
S
N
Q
Site 128
S1024
Q
R
R
P
S
V
G
S
Q
S
N
Q
A
G
Q
Site 129
S1026
R
P
S
V
G
S
Q
S
N
Q
A
G
Q
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation