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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FAF1
Full Name:
FAS-associated factor 1
Alias:
CGI-03; Fas (TNFRSF6) associated factor 1; HFAF1; HFAF1s; TNFRSF6-associated factor 1; UBX domain protein 3A; UBX domain-containing protein 12; UBX domain-containing protein 3A; UBXD12; UBXN3A
Type:
Apoptosis; Nuclear receptor co-regulator
Mass (Da):
73954
Number AA:
650
UniProt ID:
Q9UNN5
International Prot ID:
IPI00070643
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031265
GO:0005829
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0051059
GO:0031072
GO:0019901
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007253
GO:0043065
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y56
N
G
I
L
Q
S
E
Y
G
G
E
T
I
P
G
Site 2
S70
G
P
A
F
N
P
A
S
H
P
A
S
A
P
T
Site 3
S74
N
P
A
S
H
P
A
S
A
P
T
S
S
S
S
Site 4
T77
S
H
P
A
S
A
P
T
S
S
S
S
S
A
F
Site 5
S78
H
P
A
S
A
P
T
S
S
S
S
S
A
F
R
Site 6
S79
P
A
S
A
P
T
S
S
S
S
S
A
F
R
P
Site 7
S80
A
S
A
P
T
S
S
S
S
S
A
F
R
P
V
Site 8
S81
S
A
P
T
S
S
S
S
S
A
F
R
P
V
M
Site 9
S82
A
P
T
S
S
S
S
S
A
F
R
P
V
M
P
Site 10
S90
A
F
R
P
V
M
P
S
R
Q
I
V
E
R
Q
Site 11
Y107
M
L
D
F
R
V
E
Y
R
D
R
N
V
D
V
Site 12
S138
N
E
L
Q
I
P
V
S
K
M
L
L
K
G
W
Site 13
T147
M
L
L
K
G
W
K
T
G
D
V
E
D
S
T
Site 14
S153
K
T
G
D
V
E
D
S
T
V
L
K
S
L
H
Site 15
T154
T
G
D
V
E
D
S
T
V
L
K
S
L
H
L
Site 16
S158
E
D
S
T
V
L
K
S
L
H
L
P
K
N
N
Site 17
S166
L
H
L
P
K
N
N
S
L
Y
V
L
T
P
D
Site 18
Y168
L
P
K
N
N
S
L
Y
V
L
T
P
D
L
P
Site 19
T171
N
N
S
L
Y
V
L
T
P
D
L
P
P
P
S
Site 20
S178
T
P
D
L
P
P
P
S
S
S
S
H
A
G
A
Site 21
S179
P
D
L
P
P
P
S
S
S
S
H
A
G
A
L
Site 22
S181
L
P
P
P
S
S
S
S
H
A
G
A
L
Q
E
Site 23
S189
H
A
G
A
L
Q
E
S
L
N
Q
N
F
M
L
Site 24
Y207
H
R
E
V
Q
R
E
Y
N
L
N
F
S
G
S
Site 25
S212
R
E
Y
N
L
N
F
S
G
S
S
T
I
Q
E
Site 26
S214
Y
N
L
N
F
S
G
S
S
T
I
Q
E
V
K
Site 27
T216
L
N
F
S
G
S
S
T
I
Q
E
V
K
R
N
Site 28
Y225
Q
E
V
K
R
N
V
Y
D
L
T
S
I
P
V
Site 29
T228
K
R
N
V
Y
D
L
T
S
I
P
V
R
H
Q
Site 30
S229
R
N
V
Y
D
L
T
S
I
P
V
R
H
Q
L
Site 31
T245
E
G
W
P
T
S
A
T
D
D
S
M
C
L
A
Site 32
S248
P
T
S
A
T
D
D
S
M
C
L
A
E
S
G
Site 33
S254
D
S
M
C
L
A
E
S
G
L
S
Y
P
C
H
Site 34
T264
S
Y
P
C
H
R
L
T
V
G
R
R
S
S
P
Site 35
S269
R
L
T
V
G
R
R
S
S
P
A
Q
T
R
E
Site 36
S270
L
T
V
G
R
R
S
S
P
A
Q
T
R
E
Q
Site 37
T274
R
R
S
S
P
A
Q
T
R
E
Q
S
E
E
Q
Site 38
S278
P
A
Q
T
R
E
Q
S
E
E
Q
I
T
D
V
Site 39
T283
E
Q
S
E
E
Q
I
T
D
V
H
M
V
S
D
Site 40
S289
I
T
D
V
H
M
V
S
D
S
D
G
D
D
F
Site 41
S291
D
V
H
M
V
S
D
S
D
G
D
D
F
E
D
Site 42
T300
G
D
D
F
E
D
A
T
E
F
G
V
D
D
G
Site 43
S314
G
E
V
F
G
M
A
S
S
A
L
R
K
S
P
Site 44
S315
E
V
F
G
M
A
S
S
A
L
R
K
S
P
M
Site 45
S320
A
S
S
A
L
R
K
S
P
M
M
P
E
N
A
Site 46
T338
G
D
A
L
L
Q
F
T
A
E
F
S
S
R
Y
Site 47
Y366
A
A
F
Q
E
A
F
Y
V
K
A
R
D
R
K
Site 48
Y378
D
R
K
L
L
A
I
Y
L
H
H
D
E
S
V
Site 49
S419
A
W
D
L
T
K
D
S
N
R
A
R
F
L
T
Site 50
T439
F
G
S
V
V
A
Q
T
I
R
T
Q
K
T
D
Site 51
T472
N
V
I
Q
G
N
T
T
V
D
E
L
M
M
R
Site 52
Y515
K
R
E
Q
D
E
A
Y
R
L
S
L
E
A
D
Site 53
S518
Q
D
E
A
Y
R
L
S
L
E
A
D
R
A
K
Site 54
S556
E
R
E
A
I
R
L
S
L
E
Q
A
L
P
P
Site 55
S574
E
E
N
A
E
P
V
S
K
L
R
I
R
T
P
Site 56
T580
V
S
K
L
R
I
R
T
P
S
G
E
F
L
E
Site 57
S582
K
L
R
I
R
T
P
S
G
E
F
L
E
R
R
Site 58
Y613
K
G
F
P
W
D
E
Y
K
L
L
S
T
F
P
Site 59
S617
W
D
E
Y
K
L
L
S
T
F
P
R
R
D
V
Site 60
T618
D
E
Y
K
L
L
S
T
F
P
R
R
D
V
T
Site 61
T625
T
F
P
R
R
D
V
T
Q
L
D
P
N
K
S
Site 62
S632
T
Q
L
D
P
N
K
S
L
L
E
V
K
L
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation