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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP26
Full Name:
Rho GTPase-activating protein 26
Alias:
Graf; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); GTPase regulator associated with the focal adhesion kinase pp125; KIAA0621; Oligophrenin-1 like protein; Oligophrenin-1-like protein; OPHN1L; OPHN1L1; RHG26; Rho GTPase activating protein 26; RhoGAP 26; Rho-GTPase-activating protein 26; Rho-type GTPase-activating protein 26
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
92235
Number AA:
814
UniProt ID:
Q9UNA1
International Prot ID:
IPI00007913
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005925
Uniprot
OncoNet
Molecular Function:
GO:0005100
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0007399
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
F
S
D
C
C
L
D
S
P
H
F
R
E
T
L
Site 2
T21
D
S
P
H
F
R
E
T
L
K
S
H
E
A
E
Site 3
S24
H
F
R
E
T
L
K
S
H
E
A
E
L
D
K
Site 4
T32
H
E
A
E
L
D
K
T
N
K
F
I
K
E
L
Site 5
S45
E
L
I
K
D
G
K
S
L
I
S
A
L
K
N
Site 6
S48
K
D
G
K
S
L
I
S
A
L
K
N
L
S
S
Site 7
S55
S
A
L
K
N
L
S
S
A
K
R
K
F
A
D
Site 8
S63
A
K
R
K
F
A
D
S
L
N
E
F
K
F
Q
Site 9
T92
R
S
L
Q
E
F
A
T
V
L
R
N
L
E
D
Site 10
T114
N
A
S
E
V
L
I
T
P
L
E
K
F
R
K
Site 11
Y134
A
K
E
A
K
K
K
Y
D
K
E
T
E
K
Y
Site 12
T138
K
K
K
Y
D
K
E
T
E
K
Y
C
G
I
L
Site 13
Y141
Y
D
K
E
T
E
K
Y
C
G
I
L
E
K
H
Site 14
S152
L
E
K
H
L
N
L
S
S
K
K
K
E
S
Q
Site 15
S153
E
K
H
L
N
L
S
S
K
K
K
E
S
Q
L
Site 16
S165
S
Q
L
Q
E
A
D
S
Q
V
D
L
V
R
Q
Site 17
Y175
D
L
V
R
Q
H
F
Y
E
V
S
L
E
Y
V
Site 18
T226
K
D
F
G
D
F
K
T
Q
L
T
I
S
I
Q
Site 19
T229
G
D
F
K
T
Q
L
T
I
S
I
Q
N
T
R
Site 20
T235
L
T
I
S
I
Q
N
T
R
N
R
F
E
G
T
Site 21
S244
N
R
F
E
G
T
R
S
E
V
E
S
L
M
K
Site 22
S248
G
T
R
S
E
V
E
S
L
M
K
K
M
K
E
Site 23
T262
E
N
P
L
E
H
K
T
I
S
P
Y
T
M
E
Site 24
S264
P
L
E
H
K
T
I
S
P
Y
T
M
E
G
Y
Site 25
Y266
E
H
K
T
I
S
P
Y
T
M
E
G
Y
L
Y
Site 26
T267
H
K
T
I
S
P
Y
T
M
E
G
Y
L
Y
V
Site 27
Y271
S
P
Y
T
M
E
G
Y
L
Y
V
Q
E
K
R
Site 28
Y273
Y
T
M
E
G
Y
L
Y
V
Q
E
K
R
H
F
Site 29
T299
Q
R
D
S
K
Q
I
T
M
V
P
F
D
Q
K
Site 30
S307
M
V
P
F
D
Q
K
S
G
G
K
G
G
E
D
Site 31
S316
G
K
G
G
E
D
E
S
V
I
L
K
S
C
T
Site 32
S321
D
E
S
V
I
L
K
S
C
T
R
R
K
T
D
Site 33
T327
K
S
C
T
R
R
K
T
D
S
I
E
K
R
F
Site 34
S329
C
T
R
R
K
T
D
S
I
E
K
R
F
C
F
Site 35
T348
V
D
R
P
G
V
I
T
M
Q
A
L
S
E
E
Site 36
S353
V
I
T
M
Q
A
L
S
E
E
D
R
R
L
W
Site 37
Y371
M
D
G
R
E
P
V
Y
N
S
N
K
D
S
Q
Site 38
S373
G
R
E
P
V
Y
N
S
N
K
D
S
Q
S
E
Site 39
S377
V
Y
N
S
N
K
D
S
Q
S
E
G
T
A
Q
Site 40
S379
N
S
N
K
D
S
Q
S
E
G
T
A
Q
L
D
Site 41
T402
K
C
I
H
A
V
E
T
R
G
I
N
E
Q
G
Site 42
Y411
G
I
N
E
Q
G
L
Y
R
I
V
G
V
N
S
Site 43
S425
S
R
V
Q
K
L
L
S
V
L
M
D
P
K
T
Site 44
T432
S
V
L
M
D
P
K
T
A
S
E
T
E
T
D
Site 45
S434
L
M
D
P
K
T
A
S
E
T
E
T
D
I
C
Site 46
T438
K
T
A
S
E
T
E
T
D
I
C
A
E
W
E
Site 47
Y456
I
T
S
A
L
K
T
Y
L
R
M
L
P
G
P
Site 48
Y467
L
P
G
P
L
M
M
Y
Q
F
Q
R
S
F
I
Site 49
S484
A
K
L
E
N
Q
E
S
R
V
S
E
I
H
S
Site 50
S487
E
N
Q
E
S
R
V
S
E
I
H
S
L
V
H
Site 51
S491
S
R
V
S
E
I
H
S
L
V
H
R
L
P
E
Site 52
T570
N
H
E
K
I
F
N
T
V
P
D
M
P
L
T
Site 53
T577
T
V
P
D
M
P
L
T
N
A
Q
L
H
L
S
Site 54
S584
T
N
A
Q
L
H
L
S
R
K
K
S
S
D
S
Site 55
S588
L
H
L
S
R
K
K
S
S
D
S
K
P
P
S
Site 56
S589
H
L
S
R
K
K
S
S
D
S
K
P
P
S
C
Site 57
S591
S
R
K
K
S
S
D
S
K
P
P
S
C
S
E
Site 58
S595
S
S
D
S
K
P
P
S
C
S
E
R
P
L
T
Site 59
S597
D
S
K
P
P
S
C
S
E
R
P
L
T
L
F
Site 60
T602
S
C
S
E
R
P
L
T
L
F
H
T
V
Q
S
Site 61
T606
R
P
L
T
L
F
H
T
V
Q
S
T
E
K
Q
Site 62
S618
E
K
Q
E
Q
R
N
S
I
I
N
S
S
L
E
Site 63
S622
Q
R
N
S
I
I
N
S
S
L
E
S
V
S
S
Site 64
S623
R
N
S
I
I
N
S
S
L
E
S
V
S
S
N
Site 65
S626
I
I
N
S
S
L
E
S
V
S
S
N
P
N
S
Site 66
S628
N
S
S
L
E
S
V
S
S
N
P
N
S
I
L
Site 67
S629
S
S
L
E
S
V
S
S
N
P
N
S
I
L
N
Site 68
S633
S
V
S
S
N
P
N
S
I
L
N
S
S
S
S
Site 69
S637
N
P
N
S
I
L
N
S
S
S
S
L
Q
P
N
Site 70
S640
S
I
L
N
S
S
S
S
L
Q
P
N
M
N
S
Site 71
S648
L
Q
P
N
M
N
S
S
D
P
D
L
A
V
V
Site 72
S662
V
K
P
T
R
P
N
S
L
P
P
N
P
S
P
Site 73
S668
N
S
L
P
P
N
P
S
P
T
S
P
L
S
P
Site 74
T670
L
P
P
N
P
S
P
T
S
P
L
S
P
S
W
Site 75
S671
P
P
N
P
S
P
T
S
P
L
S
P
S
W
P
Site 76
S674
P
S
P
T
S
P
L
S
P
S
W
P
M
F
S
Site 77
S676
P
T
S
P
L
S
P
S
W
P
M
F
S
A
P
Site 78
S681
S
P
S
W
P
M
F
S
A
P
S
S
P
M
P
Site 79
S684
W
P
M
F
S
A
P
S
S
P
M
P
T
S
S
Site 80
S685
P
M
F
S
A
P
S
S
P
M
P
T
S
S
T
Site 81
T689
A
P
S
S
P
M
P
T
S
S
T
S
S
D
S
Site 82
S690
P
S
S
P
M
P
T
S
S
T
S
S
D
S
S
Site 83
S691
S
S
P
M
P
T
S
S
T
S
S
D
S
S
P
Site 84
T692
S
P
M
P
T
S
S
T
S
S
D
S
S
P
V
Site 85
S693
P
M
P
T
S
S
T
S
S
D
S
S
P
V
R
Site 86
S694
M
P
T
S
S
T
S
S
D
S
S
P
V
R
S
Site 87
S696
T
S
S
T
S
S
D
S
S
P
V
R
S
V
A
Site 88
S697
S
S
T
S
S
D
S
S
P
V
R
S
V
A
G
Site 89
S754
E
E
A
V
H
E
D
S
S
T
P
F
R
K
A
Site 90
S755
E
A
V
H
E
D
S
S
T
P
F
R
K
A
K
Site 91
T756
A
V
H
E
D
S
S
T
P
F
R
K
A
K
A
Site 92
Y765
F
R
K
A
K
A
L
Y
A
C
K
A
E
H
D
Site 93
S773
A
C
K
A
E
H
D
S
E
L
S
F
T
A
G
Site 94
S776
A
E
H
D
S
E
L
S
F
T
A
G
T
V
F
Site 95
T778
H
D
S
E
L
S
F
T
A
G
T
V
F
D
N
Site 96
S789
V
F
D
N
V
H
P
S
Q
E
P
G
W
L
E
Site 97
T798
E
P
G
W
L
E
G
T
L
N
G
K
T
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation