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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPX2
Full Name:
Targeting protein for Xklp2
Alias:
C20orf1; C20orf2; Differentially expressed in lung cells 2; DIL2; DIL-2; HCA519; Hepatocellular carcinoma-associated antigen 519; P100; Protein FLS353; Restricted expression proliferation associated protein 100; Restricted expression proliferation-associated protein 100; TPX2, microtubule-associated,
Type:
Cell cycle regulation
Mass (Da):
85653
Number AA:
747
UniProt ID:
Q9ULW0
International Prot ID:
IPI00008477
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005819
GO:0005819
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005525
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0007067
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
Q
V
K
S
S
Y
S
Y
D
A
P
Site 2
S7
_
M
S
Q
V
K
S
S
Y
S
Y
D
A
P
S
Site 3
S9
S
Q
V
K
S
S
Y
S
Y
D
A
P
S
D
F
Site 4
Y10
Q
V
K
S
S
Y
S
Y
D
A
P
S
D
F
I
Site 5
S14
S
Y
S
Y
D
A
P
S
D
F
I
N
F
S
S
Site 6
S20
P
S
D
F
I
N
F
S
S
L
D
D
E
G
D
Site 7
S21
S
D
F
I
N
F
S
S
L
D
D
E
G
D
T
Site 8
T28
S
L
D
D
E
G
D
T
Q
N
I
D
S
W
F
Site 9
S33
G
D
T
Q
N
I
D
S
W
F
E
E
K
A
N
Site 10
T51
K
L
L
G
K
N
G
T
G
G
L
F
Q
G
K
Site 11
T59
G
G
L
F
Q
G
K
T
P
L
R
K
A
N
L
Site 12
T72
N
L
Q
Q
A
I
V
T
P
L
K
P
V
D
N
Site 13
T80
P
L
K
P
V
D
N
T
Y
Y
K
E
A
E
K
Site 14
Y81
L
K
P
V
D
N
T
Y
Y
K
E
A
E
K
E
Site 15
Y82
K
P
V
D
N
T
Y
Y
K
E
A
E
K
E
N
Site 16
S97
L
V
E
Q
S
I
P
S
N
A
C
S
S
L
E
Site 17
S110
L
E
V
E
A
A
I
S
R
K
T
P
A
Q
P
Site 18
T113
E
A
A
I
S
R
K
T
P
A
Q
P
Q
R
R
Site 19
S121
P
A
Q
P
Q
R
R
S
L
R
L
S
A
Q
K
Site 20
S125
Q
R
R
S
L
R
L
S
A
Q
K
D
L
E
Q
Site 21
T147
M
K
A
K
R
C
A
T
P
V
I
I
D
E
I
Site 22
S157
I
I
D
E
I
L
P
S
K
K
M
K
V
S
N
Site 23
S163
P
S
K
K
M
K
V
S
N
N
K
K
K
P
E
Site 24
S174
K
K
P
E
E
E
G
S
A
H
Q
D
T
A
E
Site 25
T179
E
G
S
A
H
Q
D
T
A
E
K
N
A
S
S
Site 26
S185
D
T
A
E
K
N
A
S
S
P
E
K
A
K
G
Site 27
S186
T
A
E
K
N
A
S
S
P
E
K
A
K
G
R
Site 28
T195
E
K
A
K
G
R
H
T
V
P
C
M
P
P
A
Site 29
S209
A
K
Q
K
F
L
K
S
T
E
E
Q
E
L
E
Site 30
T210
K
Q
K
F
L
K
S
T
E
E
Q
E
L
E
K
Site 31
S218
E
E
Q
E
L
E
K
S
M
K
M
Q
Q
E
V
Site 32
S250
I
G
Q
P
V
K
K
S
V
S
Q
V
T
K
S
Site 33
S252
Q
P
V
K
K
S
V
S
Q
V
T
K
S
V
D
Site 34
S257
S
V
S
Q
V
T
K
S
V
D
F
H
F
R
T
Site 35
T264
S
V
D
F
H
F
R
T
D
E
R
I
K
Q
H
Site 36
Y278
H
P
K
N
Q
E
E
Y
K
E
V
N
F
T
S
Site 37
T284
E
Y
K
E
V
N
F
T
S
E
L
R
K
H
P
Site 38
S285
Y
K
E
V
N
F
T
S
E
L
R
K
H
P
S
Site 39
S292
S
E
L
R
K
H
P
S
S
P
A
R
V
T
K
Site 40
S293
E
L
R
K
H
P
S
S
P
A
R
V
T
K
G
Site 41
T298
P
S
S
P
A
R
V
T
K
G
C
T
I
V
K
Site 42
S310
I
V
K
P
F
N
L
S
Q
G
K
K
R
T
F
Site 43
T316
L
S
Q
G
K
K
R
T
F
D
E
T
V
S
T
Site 44
T320
K
K
R
T
F
D
E
T
V
S
T
Y
V
P
L
Site 45
S322
R
T
F
D
E
T
V
S
T
Y
V
P
L
A
Q
Site 46
T323
T
F
D
E
T
V
S
T
Y
V
P
L
A
Q
Q
Site 47
Y324
F
D
E
T
V
S
T
Y
V
P
L
A
Q
Q
V
Site 48
T338
V
E
D
F
H
K
R
T
P
N
R
Y
H
L
R
Site 49
Y342
H
K
R
T
P
N
R
Y
H
L
R
S
K
K
D
Site 50
S346
P
N
R
Y
H
L
R
S
K
K
D
D
I
N
L
Site 51
S356
D
D
I
N
L
L
P
S
K
S
S
V
T
K
I
Site 52
S358
I
N
L
L
P
S
K
S
S
V
T
K
I
C
R
Site 53
S359
N
L
L
P
S
K
S
S
V
T
K
I
C
R
D
Site 54
T361
L
P
S
K
S
S
V
T
K
I
C
R
D
P
Q
Site 55
T369
K
I
C
R
D
P
Q
T
P
V
L
Q
T
K
H
Site 56
T374
P
Q
T
P
V
L
Q
T
K
H
R
A
R
A
V
Site 57
T382
K
H
R
A
R
A
V
T
C
K
S
T
A
E
L
Site 58
S385
A
R
A
V
T
C
K
S
T
A
E
L
E
A
E
Site 59
T386
R
A
V
T
C
K
S
T
A
E
L
E
A
E
E
Site 60
T428
K
P
P
V
K
P
P
T
E
P
I
G
F
D
L
Site 61
S446
K
R
I
Q
E
R
E
S
K
K
K
T
E
D
E
Site 62
T450
E
R
E
S
K
K
K
T
E
D
E
H
F
E
F
Site 63
T482
E
K
K
V
L
P
I
T
V
P
K
S
P
A
F
Site 64
S486
L
P
I
T
V
P
K
S
P
A
F
A
L
K
N
Site 65
T499
K
N
R
I
R
M
P
T
K
E
D
E
E
E
D
Site 66
Y519
K
A
Q
P
V
P
H
Y
G
V
P
F
K
P
Q
Site 67
T532
P
Q
I
P
E
A
R
T
V
E
I
C
P
F
S
Site 68
S539
T
V
E
I
C
P
F
S
F
D
S
R
D
K
E
Site 69
S542
I
C
P
F
S
F
D
S
R
D
K
E
R
Q
L
Site 70
T576
L
P
L
P
H
F
D
T
I
N
L
P
E
K
K
Site 71
T597
I
E
P
F
C
L
E
T
D
R
R
G
A
L
K
Site 72
T631
C
F
K
A
R
P
N
T
V
I
S
Q
E
P
F
Site 73
S634
A
R
P
N
T
V
I
S
Q
E
P
F
V
P
K
Site 74
S646
V
P
K
K
E
K
K
S
V
A
E
G
L
S
G
Site 75
S652
K
S
V
A
E
G
L
S
G
S
L
V
Q
E
P
Site 76
S654
V
A
E
G
L
S
G
S
L
V
Q
E
P
F
Q
Site 77
Y721
K
A
N
P
I
R
K
Y
Q
G
L
E
I
K
S
Site 78
S728
Y
Q
G
L
E
I
K
S
S
D
Q
P
L
T
V
Site 79
S729
Q
G
L
E
I
K
S
S
D
Q
P
L
T
V
P
Site 80
T734
K
S
S
D
Q
P
L
T
V
P
V
S
P
K
F
Site 81
S738
Q
P
L
T
V
P
V
S
P
K
F
S
T
R
F
Site 82
S742
V
P
V
S
P
K
F
S
T
R
F
H
C
_
_
Site 83
T743
P
V
S
P
K
F
S
T
R
F
H
C
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation