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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZMYND8
Full Name:
ISOFORM 2 OF PROTEIN KINASE C-BINDING PROTEIN 1.
Alias:
CTCL tumor antigen se14-3; Cutaneous T-cell lymphoma associated antigen se14-3; KIAA1125; PKCB; PKCB1; PRKCBP1; Protein kinase C binding protein 1; RACK7; Zinc finger MYND domain containing protein 8; Zinc finger, MYND-type containing 8
Type:
Transcription protein
Mass (Da):
131692
Number AA:
1186
UniProt ID:
Q9ULU4
International Prot ID:
IPI00385321
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
I
S
T
R
S
K
D
P
G
S
A
E
Site 2
S12
T
R
S
K
D
P
G
S
A
E
R
T
A
Q
K
Site 3
T16
D
P
G
S
A
E
R
T
A
Q
K
R
K
F
P
Site 4
S24
A
Q
K
R
K
F
P
S
P
P
H
S
S
N
G
Site 5
S28
K
F
P
S
P
P
H
S
S
N
G
H
S
P
Q
Site 6
S29
F
P
S
P
P
H
S
S
N
G
H
S
P
Q
D
Site 7
S33
P
H
S
S
N
G
H
S
P
Q
D
T
S
T
S
Site 8
T37
N
G
H
S
P
Q
D
T
S
T
S
P
I
K
K
Site 9
S38
G
H
S
P
Q
D
T
S
T
S
P
I
K
K
K
Site 10
S40
S
P
Q
D
T
S
T
S
P
I
K
K
K
K
K
Site 11
S53
K
K
P
G
L
L
N
S
N
N
K
E
Q
S
E
Site 12
Y67
E
L
R
H
G
P
F
Y
Y
M
K
Q
P
L
T
Site 13
Y68
L
R
H
G
P
F
Y
Y
M
K
Q
P
L
T
T
Site 14
T74
Y
Y
M
K
Q
P
L
T
T
D
P
V
D
V
V
Site 15
T118
H
A
K
C
L
R
L
T
S
E
P
E
G
D
W
Site 16
S119
A
K
C
L
R
L
T
S
E
P
E
G
D
W
F
Site 17
T141
T
V
A
E
C
I
E
T
Q
S
K
A
M
T
M
Site 18
Y185
P
L
E
Q
H
P
D
Y
A
E
Y
I
F
H
P
Site 19
T197
F
H
P
M
D
L
C
T
L
E
K
N
A
K
K
Site 20
T235
N
G
G
N
H
K
L
T
Q
I
A
K
V
V
I
Site 21
Y322
W
V
P
I
N
N
C
Y
L
M
S
K
E
I
P
Site 22
S331
M
S
K
E
I
P
F
S
V
K
K
T
K
S
I
Site 23
T335
I
P
F
S
V
K
K
T
K
S
I
F
N
S
A
Site 24
S337
F
S
V
K
K
T
K
S
I
F
N
S
A
M
Q
Site 25
S341
K
T
K
S
I
F
N
S
A
M
Q
E
M
E
V
Site 26
Y349
A
M
Q
E
M
E
V
Y
V
E
N
I
R
R
K
Site 27
Y362
R
K
F
G
V
F
N
Y
S
P
F
R
T
P
Y
Site 28
S363
K
F
G
V
F
N
Y
S
P
F
R
T
P
Y
T
Site 29
T367
F
N
Y
S
P
F
R
T
P
Y
T
P
N
S
Q
Site 30
Y369
Y
S
P
F
R
T
P
Y
T
P
N
S
Q
Y
Q
Site 31
T370
S
P
F
R
T
P
Y
T
P
N
S
Q
Y
Q
M
Site 32
S373
R
T
P
Y
T
P
N
S
Q
Y
Q
M
L
L
D
Site 33
T382
Y
Q
M
L
L
D
P
T
N
P
S
A
G
T
A
Site 34
T404
V
K
L
N
F
D
M
T
A
S
P
K
I
L
M
Site 35
S406
L
N
F
D
M
T
A
S
P
K
I
L
M
S
K
Site 36
S412
A
S
P
K
I
L
M
S
K
P
V
L
S
G
G
Site 37
S417
L
M
S
K
P
V
L
S
G
G
T
G
R
R
I
Site 38
T420
K
P
V
L
S
G
G
T
G
R
R
I
S
L
S
Site 39
S425
G
G
T
G
R
R
I
S
L
S
D
M
P
R
S
Site 40
S427
T
G
R
R
I
S
L
S
D
M
P
R
S
P
M
Site 41
S432
S
L
S
D
M
P
R
S
P
M
S
T
N
S
S
Site 42
S435
D
M
P
R
S
P
M
S
T
N
S
S
V
H
T
Site 43
T436
M
P
R
S
P
M
S
T
N
S
S
V
H
T
G
Site 44
S438
R
S
P
M
S
T
N
S
S
V
H
T
G
S
D
Site 45
S439
S
P
M
S
T
N
S
S
V
H
T
G
S
D
V
Site 46
T442
S
T
N
S
S
V
H
T
G
S
D
V
E
Q
D
Site 47
S444
N
S
S
V
H
T
G
S
D
V
E
Q
D
A
E
Site 48
T455
Q
D
A
E
K
K
A
T
S
S
H
F
S
A
S
Site 49
S456
D
A
E
K
K
A
T
S
S
H
F
S
A
S
E
Site 50
S457
A
E
K
K
A
T
S
S
H
F
S
A
S
E
E
Site 51
S460
K
A
T
S
S
H
F
S
A
S
E
E
S
M
D
Site 52
S462
T
S
S
H
F
S
A
S
E
E
S
M
D
F
L
Site 53
S465
H
F
S
A
S
E
E
S
M
D
F
L
D
K
S
Site 54
S472
S
M
D
F
L
D
K
S
T
A
S
P
A
S
T
Site 55
T473
M
D
F
L
D
K
S
T
A
S
P
A
S
T
K
Site 56
S475
F
L
D
K
S
T
A
S
P
A
S
T
K
T
G
Site 57
S478
K
S
T
A
S
P
A
S
T
K
T
G
Q
A
G
Site 58
T479
S
T
A
S
P
A
S
T
K
T
G
Q
A
G
S
Site 59
T481
A
S
P
A
S
T
K
T
G
Q
A
G
S
L
S
Site 60
S486
T
K
T
G
Q
A
G
S
L
S
G
S
P
K
P
Site 61
S488
T
G
Q
A
G
S
L
S
G
S
P
K
P
F
S
Site 62
S490
Q
A
G
S
L
S
G
S
P
K
P
F
S
P
Q
Site 63
S495
S
G
S
P
K
P
F
S
P
Q
L
S
A
P
I
Site 64
S499
K
P
F
S
P
Q
L
S
A
P
I
T
T
K
T
Site 65
T503
P
Q
L
S
A
P
I
T
T
K
T
D
K
T
S
Site 66
T506
S
A
P
I
T
T
K
T
D
K
T
S
T
T
G
Site 67
T509
I
T
T
K
T
D
K
T
S
T
T
G
S
I
L
Site 68
S510
Q
A
G
S
L
S
G
S
P
K
P
F
S
P
Q
Site 69
S514
T
E
T
L
N
K
S
S
Q
G
S
S
S
S
T
Site 70
S523
L
N
L
N
L
D
R
S
K
A
E
M
D
L
K
Site 71
S533
E
M
D
L
K
E
L
S
E
S
V
Q
Q
Q
S
Site 72
S535
D
L
K
E
L
S
E
S
V
Q
Q
Q
S
T
P
Site 73
S540
S
E
S
V
Q
Q
Q
S
T
P
V
P
L
I
S
Site 74
T541
E
S
V
Q
Q
Q
S
T
P
V
P
L
I
S
P
Site 75
S547
S
T
P
V
P
L
I
S
P
K
R
Q
I
R
S
Site 76
S554
S
P
K
R
Q
I
R
S
R
F
Q
L
N
L
D
Site 77
T563
F
Q
L
N
L
D
K
T
I
E
S
C
K
A
Q
Site 78
Y581
N
E
I
S
E
D
V
Y
T
A
V
E
H
S
D
Site 79
T582
E
I
S
E
D
V
Y
T
A
V
E
H
S
D
S
Site 80
S587
V
Y
T
A
V
E
H
S
D
S
E
D
S
E
K
Site 81
S589
T
A
V
E
H
S
D
S
E
D
S
E
K
S
D
Site 82
S592
E
H
S
D
S
E
D
S
E
K
S
D
S
S
D
Site 83
S595
D
S
E
D
S
E
K
S
D
S
S
D
S
E
Y
Site 84
S597
E
D
S
E
K
S
D
S
S
D
S
E
Y
I
S
Site 85
S598
D
S
E
K
S
D
S
S
D
S
E
Y
I
S
D
Site 86
S600
E
K
S
D
S
S
D
S
E
Y
I
S
D
D
E
Site 87
Y602
S
D
S
S
D
S
E
Y
I
S
D
D
E
Q
K
Site 88
S604
S
S
D
S
E
Y
I
S
D
D
E
Q
K
S
K
Site 89
S610
I
S
D
D
E
Q
K
S
K
N
E
P
E
D
T
Site 90
T617
S
K
N
E
P
E
D
T
E
D
K
E
G
C
Q
Site 91
T639
V
K
K
K
P
K
P
T
N
P
V
E
I
K
E
Site 92
S650
E
I
K
E
E
L
K
S
T
S
P
A
S
E
K
Site 93
T651
I
K
E
E
L
K
S
T
S
P
A
S
E
K
A
Site 94
S652
K
E
E
L
K
S
T
S
P
A
S
E
K
A
D
Site 95
S655
L
K
S
T
S
P
A
S
E
K
A
D
P
G
A
Site 96
S668
G
A
V
K
D
K
A
S
P
E
P
E
K
D
F
Site 97
S676
P
E
P
E
K
D
F
S
E
K
A
K
P
S
P
Site 98
S682
F
S
E
K
A
K
P
S
P
H
P
I
K
D
K
Site 99
T696
K
L
K
G
K
D
E
T
D
S
P
T
V
H
L
Site 100
S698
K
G
K
D
E
T
D
S
P
T
V
H
L
G
L
Site 101
T700
K
D
E
T
D
S
P
T
V
H
L
G
L
D
S
Site 102
S707
T
V
H
L
G
L
D
S
D
S
E
S
E
L
V
Site 103
S709
H
L
G
L
D
S
D
S
E
S
E
L
V
I
D
Site 104
S711
G
L
D
S
D
S
E
S
E
L
V
I
D
L
G
Site 105
S722
I
D
L
G
E
D
H
S
G
R
E
G
R
K
N
Site 106
S737
K
K
E
P
K
E
P
S
P
K
Q
D
V
V
G
Site 107
T746
K
Q
D
V
V
G
K
T
P
P
S
T
T
V
G
Site 108
S749
V
V
G
K
T
P
P
S
T
T
V
G
S
H
S
Site 109
T750
V
G
K
T
P
P
S
T
T
V
G
S
H
S
P
Site 110
T751
G
K
T
P
P
S
T
T
V
G
S
H
S
P
P
Site 111
S754
P
P
S
T
T
V
G
S
H
S
P
P
E
T
P
Site 112
S756
S
T
T
V
G
S
H
S
P
P
E
T
P
V
L
Site 113
T760
G
S
H
S
P
P
E
T
P
V
L
T
R
S
S
Site 114
T764
P
P
E
T
P
V
L
T
R
S
S
A
Q
T
S
Site 115
S766
E
T
P
V
L
T
R
S
S
A
Q
T
S
A
A
Site 116
S767
T
P
V
L
T
R
S
S
A
Q
T
S
A
A
G
Site 117
T770
L
T
R
S
S
A
Q
T
S
A
A
G
A
T
A
Site 118
S771
T
R
S
S
A
Q
T
S
A
A
G
A
T
A
T
Site 119
S797
P
A
P
A
A
T
G
S
P
V
K
K
Q
R
P
Site 120
S821
V
Q
R
V
V
W
N
S
S
S
K
F
Q
T
S
Site 121
S823
R
V
V
W
N
S
S
S
K
F
Q
T
S
S
Q
Site 122
T827
N
S
S
S
K
F
Q
T
S
S
Q
K
W
H
M
Site 123
S828
S
S
S
K
F
Q
T
S
S
Q
K
W
H
M
Q
Site 124
S829
S
S
K
F
Q
T
S
S
Q
K
W
H
M
Q
K
Site 125
Y861
Q
S
S
Q
G
T
R
Y
Q
T
R
Q
A
V
K
Site 126
T863
S
Q
G
T
R
Y
Q
T
R
Q
A
V
K
A
V
Site 127
T876
A
V
Q
Q
K
E
I
T
Q
S
P
S
T
S
T
Site 128
S878
Q
Q
K
E
I
T
Q
S
P
S
T
S
T
I
T
Site 129
T885
S
P
S
T
S
T
I
T
L
V
T
S
T
Q
S
Site 130
S893
L
V
T
S
T
Q
S
S
P
L
V
T
S
S
G
Site 131
T897
T
Q
S
S
P
L
V
T
S
S
G
S
M
S
T
Site 132
S898
Q
S
S
P
L
V
T
S
S
G
S
M
S
T
L
Site 133
Y945
K
G
T
M
T
E
I
Y
N
D
L
S
K
N
T
Site 134
S949
T
E
I
Y
N
D
L
S
K
N
T
T
G
S
T
Site 135
T953
N
D
L
S
K
N
T
T
G
S
T
I
A
E
I
Site 136
S995
T
M
A
E
M
R
Q
S
L
E
Q
E
R
D
R
Site 137
S1065
H
M
K
S
C
T
Q
S
A
T
A
P
Q
Q
E
Site 138
T1081
D
A
E
V
N
T
E
T
L
N
K
S
S
Q
G
Site 139
S1085
N
T
E
T
L
N
K
S
S
Q
G
S
S
S
S
Site 140
S1086
T
E
T
L
N
K
S
S
Q
G
S
S
S
S
T
Site 141
S1089
L
N
K
S
S
Q
G
S
S
S
S
T
Q
S
A
Site 142
S1090
N
K
S
S
Q
G
S
S
S
S
T
Q
S
A
P
Site 143
S1091
K
S
S
Q
G
S
S
S
S
T
Q
S
A
P
S
Site 144
S1092
S
S
Q
G
S
S
S
S
T
Q
S
A
P
S
E
Site 145
T1093
S
Q
G
S
S
S
S
T
Q
S
A
P
S
E
T
Site 146
S1095
G
S
S
S
S
T
Q
S
A
P
S
E
T
A
S
Site 147
S1098
S
S
T
Q
S
A
P
S
E
T
A
S
A
S
K
Site 148
S1102
S
A
P
S
E
T
A
S
A
S
K
E
K
E
T
Site 149
S1104
P
S
E
T
A
S
A
S
K
E
K
E
T
S
A
Site 150
S1110
A
S
K
E
K
E
T
S
A
E
K
S
K
E
S
Site 151
S1114
K
E
T
S
A
E
K
S
K
E
S
G
S
T
L
Site 152
S1119
E
K
S
K
E
S
G
S
T
L
D
L
S
G
S
Site 153
T1120
K
S
K
E
S
G
S
T
L
D
L
S
G
S
R
Site 154
S1124
S
G
S
T
L
D
L
S
G
S
R
E
T
P
S
Site 155
S1126
S
T
L
D
L
S
G
S
R
E
T
P
S
S
I
Site 156
T1129
D
L
S
G
S
R
E
T
P
S
S
I
L
L
G
Site 157
S1131
S
G
S
R
E
T
P
S
S
I
L
L
G
S
N
Site 158
S1132
G
S
R
E
T
P
S
S
I
L
L
G
S
N
Q
Site 159
S1137
P
S
S
I
L
L
G
S
N
Q
G
S
D
H
S
Site 160
S1141
L
L
G
S
N
Q
G
S
D
H
S
R
S
N
K
Site 161
S1144
S
N
Q
G
S
D
H
S
R
S
N
K
S
S
W
Site 162
S1146
Q
G
S
D
H
S
R
S
N
K
S
S
W
S
S
Site 163
S1149
D
H
S
R
S
N
K
S
S
W
S
S
S
D
E
Site 164
S1150
H
S
R
S
N
K
S
S
W
S
S
S
D
E
K
Site 165
S1152
R
S
N
K
S
S
W
S
S
S
D
E
K
R
G
Site 166
S1153
S
N
K
S
S
W
S
S
S
D
E
K
R
G
S
Site 167
S1154
N
K
S
S
W
S
S
S
D
E
K
R
G
S
T
Site 168
S1160
S
S
D
E
K
R
G
S
T
R
S
D
H
N
T
Site 169
T1161
S
D
E
K
R
G
S
T
R
S
D
H
N
T
S
Site 170
S1163
E
K
R
G
S
T
R
S
D
H
N
T
S
T
S
Site 171
T1167
S
T
R
S
D
H
N
T
S
T
S
T
K
S
L
Site 172
S1168
T
R
S
D
H
N
T
S
T
S
T
K
S
L
L
Site 173
T1169
R
S
D
H
N
T
S
T
S
T
K
S
L
L
P
Site 174
S1170
S
D
H
N
T
S
T
S
T
K
S
L
L
P
K
Site 175
S1173
N
T
S
T
S
T
K
S
L
L
P
K
E
S
R
Site 176
S1179
K
S
L
L
P
K
E
S
R
L
D
T
F
W
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation