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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRR12
Full Name:
Protein proline-rich-12
Alias:
Proline-rich protein 12
Type:
DNA binding protein
Mass (Da):
129991
Number AA:
1215
UniProt ID:
Q9ULL5
International Prot ID:
IPI00181759
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S44
G
L
E
P
A
A
P
S
P
R
L
R
P
E
E
Site 2
S52
P
R
L
R
P
E
E
S
L
D
P
P
G
A
M
Site 3
T76
L
P
P
A
P
G
D
T
G
V
G
P
P
N
S
Site 4
S83
T
G
V
G
P
P
N
S
E
G
K
D
P
A
G
Site 5
Y92
G
K
D
P
A
G
A
Y
R
S
P
S
P
Q
G
Site 6
S94
D
P
A
G
A
Y
R
S
P
S
P
Q
G
T
K
Site 7
S96
A
G
A
Y
R
S
P
S
P
Q
G
T
K
A
P
Site 8
T100
R
S
P
S
P
Q
G
T
K
A
P
R
F
V
P
Site 9
S116
T
S
I
C
F
P
D
S
L
L
Q
D
E
E
R
Site 10
S124
L
L
Q
D
E
E
R
S
F
F
P
T
M
E
E
Site 11
T128
E
E
R
S
F
F
P
T
M
E
E
M
F
G
G
Site 12
Y141
G
G
G
A
A
D
D
Y
G
K
A
G
P
P
E
Site 13
Y166
P
P
P
G
P
P
A
Y
D
P
Y
G
P
Y
C
Site 14
Y169
G
P
P
A
Y
D
P
Y
G
P
Y
C
P
G
R
Site 15
Y172
A
Y
D
P
Y
G
P
Y
C
P
G
R
A
S
G
Site 16
S178
P
Y
C
P
G
R
A
S
G
A
G
P
E
T
P
Site 17
T184
A
S
G
A
G
P
E
T
P
G
L
G
L
D
P
Site 18
T200
K
P
P
E
L
P
S
T
V
N
A
E
P
L
G
Site 19
S211
E
P
L
G
L
I
Q
S
G
P
H
Q
A
A
P
Site 20
S232
P
P
P
P
A
P
A
S
E
P
K
G
G
L
T
Site 21
T239
S
E
P
K
G
G
L
T
S
P
I
F
C
S
T
Site 22
S240
E
P
K
G
G
L
T
S
P
I
F
C
S
T
K
Site 23
T246
T
S
P
I
F
C
S
T
K
P
K
K
L
L
K
Site 24
T254
K
P
K
K
L
L
K
T
S
S
F
H
L
L
R
Site 25
S255
P
K
K
L
L
K
T
S
S
F
H
L
L
R
R
Site 26
S256
K
K
L
L
K
T
S
S
F
H
L
L
R
R
R
Site 27
T269
R
R
D
P
P
F
Q
T
P
K
K
L
Y
A
Q
Site 28
S305
R
R
L
P
D
L
V
S
S
C
R
S
R
P
A
Site 29
S306
R
L
P
D
L
V
S
S
C
R
S
R
P
A
L
Site 30
S309
D
L
V
S
S
C
R
S
R
P
A
L
S
P
L
Site 31
S314
C
R
S
R
P
A
L
S
P
L
G
D
I
D
F
Site 32
T339
R
R
R
G
R
K
P
T
K
A
K
R
D
G
P
Site 33
T363
R
P
L
E
V
P
T
T
A
G
P
A
S
A
S
Site 34
S368
P
T
T
A
G
P
A
S
A
S
T
P
T
D
G
Site 35
S370
T
A
G
P
A
S
A
S
T
P
T
D
G
A
K
Site 36
T371
A
G
P
A
S
A
S
T
P
T
D
G
A
K
K
Site 37
S409
K
P
L
K
I
K
L
S
V
P
K
A
G
E
G
Site 38
T419
K
A
G
E
G
L
G
T
S
S
G
D
A
I
S
Site 39
S420
A
G
E
G
L
G
T
S
S
G
D
A
I
S
G
Site 40
S421
G
E
G
L
G
T
S
S
G
D
A
I
S
G
T
Site 41
S426
T
S
S
G
D
A
I
S
G
T
D
H
N
S
L
Site 42
T428
S
G
D
A
I
S
G
T
D
H
N
S
L
D
S
Site 43
S432
I
S
G
T
D
H
N
S
L
D
S
S
L
T
R
Site 44
S436
D
H
N
S
L
D
S
S
L
T
R
E
K
I
E
Site 45
S458
E
K
Q
P
E
M
K
S
G
F
M
A
S
F
L
Site 46
S470
S
F
L
D
F
L
K
S
G
K
R
H
P
P
L
Site 47
Y478
G
K
R
H
P
P
L
Y
Q
A
G
L
T
P
P
Site 48
T483
P
L
Y
Q
A
G
L
T
P
P
L
S
P
P
K
Site 49
S487
A
G
L
T
P
P
L
S
P
P
K
S
V
P
P
Site 50
S491
P
P
L
S
P
P
K
S
V
P
P
S
V
P
A
Site 51
S495
P
P
K
S
V
P
P
S
V
P
A
R
G
L
Q
Site 52
T508
L
Q
P
Q
P
P
A
T
P
A
V
P
H
P
P
Site 53
S540
G
L
G
L
G
C
P
S
P
C
K
R
L
D
E
Site 54
T555
E
L
K
R
N
L
E
T
L
P
S
F
S
S
D
Site 55
S558
R
N
L
E
T
L
P
S
F
S
S
D
E
E
D
Site 56
S560
L
E
T
L
P
S
F
S
S
D
E
E
D
S
V
Site 57
S561
E
T
L
P
S
F
S
S
D
E
E
D
S
V
A
Site 58
S566
F
S
S
D
E
E
D
S
V
A
K
N
R
D
L
Site 59
S576
K
N
R
D
L
Q
E
S
I
S
S
A
I
S
A
Site 60
S578
R
D
L
Q
E
S
I
S
S
A
I
S
A
L
D
Site 61
S579
D
L
Q
E
S
I
S
S
A
I
S
A
L
D
D
Site 62
S582
E
S
I
S
S
A
I
S
A
L
D
D
P
P
L
Site 63
T595
P
L
A
G
P
K
D
T
S
T
P
D
G
P
P
Site 64
S596
L
A
G
P
K
D
T
S
T
P
D
G
P
P
L
Site 65
T597
A
G
P
K
D
T
S
T
P
D
G
P
P
L
A
Site 66
S620
P
P
L
P
G
L
P
S
A
N
S
N
G
T
P
Site 67
S623
P
G
L
P
S
A
N
S
N
G
T
P
E
P
P
Site 68
T626
P
S
A
N
S
N
G
T
P
E
P
P
L
L
E
Site 69
T639
L
E
E
K
P
P
P
T
P
P
P
A
P
T
P
Site 70
T645
P
T
P
P
P
A
P
T
P
Q
P
Q
P
P
P
Site 71
S663
P
P
Q
P
A
L
P
S
P
P
P
L
V
A
P
Site 72
T671
P
P
P
L
V
A
P
T
P
S
S
P
P
P
P
Site 73
S673
P
L
V
A
P
T
P
S
S
P
P
P
P
P
L
Site 74
S674
L
V
A
P
T
P
S
S
P
P
P
P
P
L
P
Site 75
S690
P
P
P
P
A
M
P
S
P
P
P
P
P
P
P
Site 76
S713
P
E
E
P
A
A
P
S
P
E
D
P
E
L
P
Site 77
T722
E
D
P
E
L
P
D
T
R
P
L
H
L
A
K
Site 78
T740
T
A
A
V
C
G
E
T
D
E
E
A
G
E
S
Site 79
S747
T
D
E
E
A
G
E
S
G
G
E
G
I
F
R
Site 80
T775
S
L
K
L
A
L
Q
T
G
R
E
P
P
P
I
Site 81
T794
K
A
L
L
Q
K
F
T
P
E
I
K
D
G
Q
Site 82
Y810
Q
F
C
A
T
S
N
Y
L
G
Y
F
G
D
A
Site 83
Y813
A
T
S
N
Y
L
G
Y
F
G
D
A
K
N
R
Site 84
Y821
F
G
D
A
K
N
R
Y
Q
R
L
Y
V
K
F
Site 85
Y825
K
N
R
Y
Q
R
L
Y
V
K
F
L
E
N
V
Site 86
Y837
E
N
V
N
K
K
D
Y
V
R
V
C
A
R
K
Site 87
S856
P
P
V
P
V
R
R
S
G
Q
A
K
N
P
V
Site 88
S864
G
Q
A
K
N
P
V
S
A
G
G
S
S
A
P
Site 89
S868
N
P
V
S
A
G
G
S
S
A
P
P
P
K
A
Site 90
S869
P
V
S
A
G
G
S
S
A
P
P
P
K
A
P
Site 91
T884
A
P
P
P
K
P
E
T
P
E
K
T
T
S
E
Site 92
T888
K
P
E
T
P
E
K
T
T
S
E
K
P
P
E
Site 93
S890
E
T
P
E
K
T
T
S
E
K
P
P
E
Q
T
Site 94
T897
S
E
K
P
P
E
Q
T
P
E
T
A
M
P
E
Site 95
T900
P
P
E
Q
T
P
E
T
A
M
P
E
P
P
A
Site 96
T939
P
L
R
G
E
R
A
T
S
G
R
Q
T
R
P
Site 97
S940
L
R
G
E
R
A
T
S
G
R
Q
T
R
P
E
Site 98
T944
R
A
T
S
G
R
Q
T
R
P
E
R
S
L
A
Site 99
T966
R
L
P
K
A
R
P
T
K
V
K
A
E
P
P
Site 100
S997
A
G
G
G
P
P
G
S
S
S
D
S
E
S
S
Site 101
S998
G
G
G
P
P
G
S
S
S
D
S
E
S
S
P
Site 102
S999
G
G
P
P
G
S
S
S
D
S
E
S
S
P
G
Site 103
S1001
P
P
G
S
S
S
D
S
E
S
S
P
G
A
P
Site 104
S1003
G
S
S
S
D
S
E
S
S
P
G
A
P
S
E
Site 105
S1004
S
S
S
D
S
E
S
S
P
G
A
P
S
E
D
Site 106
S1009
E
S
S
P
G
A
P
S
E
D
E
R
A
V
P
Site 107
T1022
V
P
G
R
L
L
K
T
R
A
M
R
E
M
Y
Site 108
Y1029
T
R
A
M
R
E
M
Y
R
S
Y
V
E
M
L
Site 109
S1031
A
M
R
E
M
Y
R
S
Y
V
E
M
L
V
S
Site 110
Y1032
M
R
E
M
Y
R
S
Y
V
E
M
L
V
S
T
Site 111
Y1057
E
D
T
H
D
E
L
Y
L
P
P
M
R
K
I
Site 112
S1080
K
K
V
L
K
R
L
S
L
S
P
A
L
Q
D
Site 113
T1091
A
L
Q
D
A
L
H
T
F
P
Q
L
Q
V
E
Site 114
S1100
P
Q
L
Q
V
E
Q
S
G
E
G
S
P
E
E
Site 115
S1104
V
E
Q
S
G
E
G
S
P
E
E
G
A
V
R
Site 116
Y1119
L
R
P
A
G
E
P
Y
N
R
K
T
L
S
K
Site 117
T1123
G
E
P
Y
N
R
K
T
L
S
K
L
K
R
S
Site 118
S1125
P
Y
N
R
K
T
L
S
K
L
K
R
S
V
V
Site 119
S1130
T
L
S
K
L
K
R
S
V
V
R
A
Q
E
F
Site 120
Y1146
V
E
L
E
K
S
G
Y
Y
T
L
Y
H
S
L
Site 121
T1148
L
E
K
S
G
Y
Y
T
L
Y
H
S
L
H
H
Site 122
Y1150
K
S
G
Y
Y
T
L
Y
H
S
L
H
H
Y
K
Site 123
Y1156
L
Y
H
S
L
H
H
Y
K
Y
H
T
F
L
R
Site 124
T1168
F
L
R
C
R
D
Q
T
L
A
I
E
G
G
A
Site 125
S1202
E
Q
L
F
D
S
F
S
D
L
L
A
Q
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation