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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDEF1
Full Name:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Alias:
Type:
GTPase-activating protein for G protein
Mass (Da):
125471
Number AA:
956
UniProt ID:
Q9ULH1
International Prot ID:
IPI00376976
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0032312
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
R
S
S
A
S
R
L
S
S
F
S
S
Site 2
S9
R
S
S
A
S
R
L
S
S
F
S
S
R
D
S
Site 3
S10
S
S
A
S
R
L
S
S
F
S
S
R
D
S
L
Site 4
S12
A
S
R
L
S
S
F
S
S
R
D
S
L
W
N
Site 5
S13
S
R
L
S
S
F
S
S
R
D
S
L
W
N
R
Site 6
S16
S
S
F
S
S
R
D
S
L
W
N
R
M
P
D
Site 7
S26
N
R
M
P
D
Q
I
S
V
S
E
F
I
A
E
Site 8
Y38
I
A
E
T
T
E
D
Y
N
S
P
T
T
S
S
Site 9
S40
E
T
T
E
D
Y
N
S
P
T
T
S
S
F
T
Site 10
T42
T
E
D
Y
N
S
P
T
T
S
S
F
T
T
R
Site 11
S44
D
Y
N
S
P
T
T
S
S
F
T
T
R
L
H
Site 12
S45
Y
N
S
P
T
T
S
S
F
T
T
R
L
H
N
Site 13
T56
R
L
H
N
C
R
N
T
V
T
L
L
E
E
A
Site 14
T69
E
A
L
D
Q
D
R
T
A
L
Q
K
V
K
K
Site 15
S77
A
L
Q
K
V
K
K
S
V
K
A
I
Y
N
S
Site 16
Y82
K
K
S
V
K
A
I
Y
N
S
G
Q
D
H
V
Site 17
S104
Q
V
L
D
K
F
G
S
N
F
L
S
R
D
N
Site 18
S108
K
F
G
S
N
F
L
S
R
D
N
P
D
L
G
Site 19
T116
R
D
N
P
D
L
G
T
A
F
V
K
F
S
T
Site 20
Y173
F
D
K
A
W
K
D
Y
E
T
K
F
T
K
I
Site 21
T178
K
D
Y
E
T
K
F
T
K
I
E
K
E
K
R
Site 22
Y244
L
Q
N
L
I
K
Y
Y
H
A
Q
C
S
F
F
Site 23
Y273
E
K
L
A
A
D
L
Y
N
I
K
Q
T
Q
D
Site 24
S295
A
L
R
D
L
I
K
S
S
L
Q
L
D
Q
K
Site 25
S296
L
R
D
L
I
K
S
S
L
Q
L
D
Q
K
E
Site 26
S305
Q
L
D
Q
K
E
D
S
Q
S
R
Q
G
G
Y
Site 27
S307
D
Q
K
E
D
S
Q
S
R
Q
G
G
Y
S
M
Site 28
Y312
S
Q
S
R
Q
G
G
Y
S
M
H
Q
L
Q
G
Site 29
S313
Q
S
R
Q
G
G
Y
S
M
H
Q
L
Q
G
N
Site 30
S325
Q
G
N
K
E
Y
G
S
E
K
K
G
Y
L
L
Site 31
Y330
Y
G
S
E
K
K
G
Y
L
L
K
K
S
D
G
Site 32
S335
K
G
Y
L
L
K
K
S
D
G
I
R
K
V
W
Site 33
T355
S
V
K
N
G
I
L
T
I
S
H
A
T
S
N
Site 34
S357
K
N
G
I
L
T
I
S
H
A
T
S
N
R
Q
Site 35
S361
L
T
I
S
H
A
T
S
N
R
Q
P
A
K
L
Site 36
T372
P
A
K
L
N
L
L
T
C
Q
V
K
P
N
A
Site 37
S384
P
N
A
E
D
K
K
S
F
D
L
I
S
H
N
Site 38
T393
D
L
I
S
H
N
R
T
Y
H
F
Q
A
E
D
Site 39
Y394
L
I
S
H
N
R
T
Y
H
F
Q
A
E
D
E
Site 40
Y404
Q
A
E
D
E
Q
D
Y
V
A
W
I
S
V
L
Site 41
S409
Q
D
Y
V
A
W
I
S
V
L
T
N
S
K
E
Site 42
S414
W
I
S
V
L
T
N
S
K
E
E
A
L
T
M
Site 43
T420
N
S
K
E
E
A
L
T
M
A
F
R
G
E
Q
Site 44
T438
E
N
S
L
E
D
L
T
K
A
I
I
E
D
V
Site 45
T463
D
C
G
S
S
E
P
T
W
L
S
T
N
L
G
Site 46
S466
S
S
E
P
T
W
L
S
T
N
L
G
I
L
T
Site 47
S489
R
E
M
G
V
H
I
S
R
I
Q
S
L
E
L
Site 48
S493
V
H
I
S
R
I
Q
S
L
E
L
D
K
L
G
Site 49
S514
A
K
N
V
G
N
N
S
F
N
D
I
M
E
A
Site 50
S525
I
M
E
A
N
L
P
S
P
S
P
K
P
T
P
Site 51
S527
E
A
N
L
P
S
P
S
P
K
P
T
P
S
S
Site 52
T531
P
S
P
S
P
K
P
T
P
S
S
D
M
T
V
Site 53
S533
P
S
P
K
P
T
P
S
S
D
M
T
V
R
K
Site 54
S534
S
P
K
P
T
P
S
S
D
M
T
V
R
K
E
Site 55
T537
P
T
P
S
S
D
M
T
V
R
K
E
Y
I
T
Site 56
Y542
D
M
T
V
R
K
E
Y
I
T
A
K
Y
V
D
Site 57
T544
T
V
R
K
E
Y
I
T
A
K
Y
V
D
H
R
Site 58
Y547
K
E
Y
I
T
A
K
Y
V
D
H
R
F
S
R
Site 59
S553
K
Y
V
D
H
R
F
S
R
K
T
C
S
T
S
Site 60
T556
D
H
R
F
S
R
K
T
C
S
T
S
S
A
K
Site 61
S558
R
F
S
R
K
T
C
S
T
S
S
A
K
L
N
Site 62
T559
F
S
R
K
T
C
S
T
S
S
A
K
L
N
E
Site 63
S560
S
R
K
T
C
S
T
S
S
A
K
L
N
E
L
Site 64
T603
P
G
Q
E
L
G
E
T
A
L
H
L
A
V
R
Site 65
Y643
L
G
N
T
V
L
H
Y
C
S
M
Y
S
K
P
Site 66
Y647
V
L
H
Y
C
S
M
Y
S
K
P
E
C
L
K
Site 67
S690
T
Q
C
E
D
L
L
S
Q
A
K
S
G
K
F
Site 68
S694
D
L
L
S
Q
A
K
S
G
K
F
N
P
H
V
Site 69
S717
R
Q
E
E
I
D
E
S
D
D
D
L
D
D
K
Site 70
S726
D
D
L
D
D
K
P
S
P
I
K
K
E
R
S
Site 71
S733
S
P
I
K
K
E
R
S
P
R
P
Q
S
F
C
Site 72
S738
E
R
S
P
R
P
Q
S
F
C
H
S
S
S
I
Site 73
S742
R
P
Q
S
F
C
H
S
S
S
I
S
P
Q
D
Site 74
S743
P
Q
S
F
C
H
S
S
S
I
S
P
Q
D
K
Site 75
S744
Q
S
F
C
H
S
S
S
I
S
P
Q
D
K
L
Site 76
S746
F
C
H
S
S
S
I
S
P
Q
D
K
L
A
L
Site 77
T758
L
A
L
P
G
F
S
T
P
R
D
K
Q
R
L
Site 78
S766
P
R
D
K
Q
R
L
S
Y
G
A
F
T
N
Q
Site 79
Y767
R
D
K
Q
R
L
S
Y
G
A
F
T
N
Q
I
Site 80
T778
T
N
Q
I
F
V
S
T
S
T
D
S
P
T
S
Site 81
S779
N
Q
I
F
V
S
T
S
T
D
S
P
T
S
P
Site 82
T780
Q
I
F
V
S
T
S
T
D
S
P
T
S
P
T
Site 83
S782
F
V
S
T
S
T
D
S
P
T
S
P
T
T
E
Site 84
S785
T
S
T
D
S
P
T
S
P
T
T
E
A
P
P
Site 85
T788
D
S
P
T
S
P
T
T
E
A
P
P
L
P
P
Site 86
T803
R
N
A
G
K
G
P
T
G
P
P
S
T
L
P
Site 87
S807
K
G
P
T
G
P
P
S
T
L
P
L
S
T
Q
Site 88
T808
G
P
T
G
P
P
S
T
L
P
L
S
T
Q
T
Site 89
S812
P
P
S
T
L
P
L
S
T
Q
T
S
S
G
S
Site 90
T813
P
S
T
L
P
L
S
T
Q
T
S
S
G
S
S
Site 91
T815
T
L
P
L
S
T
Q
T
S
S
G
S
S
T
L
Site 92
S816
L
P
L
S
T
Q
T
S
S
G
S
S
T
L
S
Site 93
S817
P
L
S
T
Q
T
S
S
G
S
S
T
L
S
K
Site 94
S819
S
T
Q
T
S
S
G
S
S
T
L
S
K
K
R
Site 95
S820
T
Q
T
S
S
G
S
S
T
L
S
K
K
R
P
Site 96
T821
Q
T
S
S
G
S
S
T
L
S
K
K
R
P
P
Site 97
S823
S
S
G
S
S
T
L
S
K
K
R
P
P
P
P
Site 98
T837
P
P
P
G
H
K
R
T
L
S
D
P
P
S
P
Site 99
S839
P
G
H
K
R
T
L
S
D
P
P
S
P
L
P
Site 100
S843
R
T
L
S
D
P
P
S
P
L
P
H
G
P
P
Site 101
S864
W
G
N
D
G
G
P
S
S
S
S
K
T
T
N
Site 102
S865
G
N
D
G
G
P
S
S
S
S
K
T
T
N
K
Site 103
T869
G
P
S
S
S
S
K
T
T
N
K
F
E
G
L
Site 104
T870
P
S
S
S
S
K
T
T
N
K
F
E
G
L
S
Site 105
S877
T
N
K
F
E
G
L
S
Q
Q
S
S
T
S
S
Site 106
S881
E
G
L
S
Q
Q
S
S
T
S
S
A
K
T
A
Site 107
S884
S
Q
Q
S
S
T
S
S
A
K
T
A
L
G
P
Site 108
T887
S
S
T
S
S
A
K
T
A
L
G
P
R
V
L
Site 109
T906
Q
K
V
A
L
R
K
T
D
H
L
S
L
D
K
Site 110
S910
L
R
K
T
D
H
L
S
L
D
K
A
T
I
P
Site 111
T915
H
L
S
L
D
K
A
T
I
P
P
E
I
F
Q
Site 112
S924
P
P
E
I
F
Q
K
S
S
Q
L
A
E
L
P
Site 113
S925
P
E
I
F
Q
K
S
S
Q
L
A
E
L
P
Q
Site 114
S978
L
P
P
K
P
Q
L
S
D
L
P
P
K
P
Q
Site 115
S1002
L
G
D
L
L
A
K
S
Q
T
G
D
V
S
P
Site 116
T1004
D
L
L
A
K
S
Q
T
G
D
V
S
P
K
A
Site 117
S1008
K
S
Q
T
G
D
V
S
P
K
A
Q
Q
P
S
Site 118
S1021
P
S
E
V
T
L
K
S
H
P
L
D
L
S
P
Site 119
S1027
K
S
H
P
L
D
L
S
P
N
V
Q
S
R
D
Site 120
S1041
D
A
I
Q
K
Q
A
S
E
D
S
N
D
L
T
Site 121
S1044
Q
K
Q
A
S
E
D
S
N
D
L
T
P
T
L
Site 122
T1048
S
E
D
S
N
D
L
T
P
T
L
P
E
T
P
Site 123
T1050
D
S
N
D
L
T
P
T
L
P
E
T
P
V
P
Site 124
T1054
L
T
P
T
L
P
E
T
P
V
P
L
P
R
K
Site 125
T1074
N
K
V
R
R
V
K
T
I
Y
D
C
Q
A
D
Site 126
Y1076
V
R
R
V
K
T
I
Y
D
C
Q
A
D
N
D
Site 127
T1087
A
D
N
D
D
E
L
T
F
I
E
G
E
V
I
Site 128
T1097
E
G
E
V
I
I
V
T
G
E
E
D
Q
E
W
Site 129
S1128
V
S
F
V
H
I
L
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation