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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYH13
Full Name:
Myosin-13
Alias:
extraocular muscle myosin heavy chain; extraocular myosin heavy chain; MyHC-eo; MYHD; myosin heavy chain, skeletal muscle, extraocular; myosin, heavy chain 13, skeletal muscle; skeletal muscle myosin heavy chain
Type:
Motor protein
Mass (Da):
223680
Number AA:
1938
UniProt ID:
Q9UKX3
International Prot ID:
IPI00007858
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005859
GO:0030016
GO:0032982
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0006936
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
D
A
E
M
A
I
Site 2
S3
_
_
_
_
_
M
S
S
D
A
E
M
A
I
F
Site 3
Y16
I
F
G
E
A
A
P
Y
L
R
K
P
E
K
E
Site 4
Y47
V
A
D
N
K
E
M
Y
V
K
G
M
I
Q
T
Site 5
T64
N
D
K
V
I
V
K
T
L
D
D
R
M
L
T
Site 6
T71
T
L
D
D
R
M
L
T
L
N
N
D
Q
V
F
Site 7
Y104
L
H
E
P
A
V
L
Y
N
L
K
E
R
Y
A
Site 8
Y135
P
Y
K
W
L
P
V
Y
K
P
E
V
V
A
A
Site 9
S157
E
A
P
P
H
I
F
S
I
S
D
N
A
Y
Q
Site 10
Y163
F
S
I
S
D
N
A
Y
Q
F
M
L
T
D
R
Site 11
T168
N
A
Y
Q
F
M
L
T
D
R
D
N
Q
S
I
Site 12
S174
L
T
D
R
D
N
Q
S
I
L
I
T
G
E
S
Site 13
T178
D
N
Q
S
I
L
I
T
G
E
S
G
A
G
K
Site 14
T186
G
E
S
G
A
G
K
T
V
N
T
K
R
V
I
Site 15
T189
G
A
G
K
T
V
N
T
K
R
V
I
Q
Y
F
Site 16
Y195
N
T
K
R
V
I
Q
Y
F
A
T
I
A
V
T
Site 17
T209
T
G
D
K
K
K
E
T
Q
P
G
K
M
Q
G
Site 18
T237
E
A
F
G
N
A
K
T
V
R
N
D
N
S
S
Site 19
S243
K
T
V
R
N
D
N
S
S
R
F
G
K
F
I
Site 20
S244
T
V
R
N
D
N
S
S
R
F
G
K
F
I
R
Site 21
Y268
A
S
A
D
I
E
T
Y
L
L
E
K
S
R
V
Site 22
S273
E
T
Y
L
L
E
K
S
R
V
T
F
Q
L
S
Site 23
T276
L
L
E
K
S
R
V
T
F
Q
L
S
S
E
R
Site 24
S280
S
R
V
T
F
Q
L
S
S
E
R
S
Y
H
I
Site 25
S281
R
V
T
F
Q
L
S
S
E
R
S
Y
H
I
F
Site 26
Y285
Q
L
S
S
E
R
S
Y
H
I
F
Y
Q
I
M
Site 27
Y289
E
R
S
Y
H
I
F
Y
Q
I
M
S
N
K
K
Site 28
S324
Q
G
E
V
T
V
A
S
I
D
D
S
E
E
L
Site 29
S328
T
V
A
S
I
D
D
S
E
E
L
L
A
T
D
Site 30
T355
K
V
G
I
Y
K
L
T
G
A
V
M
H
Y
G
Site 31
Y361
L
T
G
A
V
M
H
Y
G
N
M
K
F
K
Q
Site 32
T380
E
Q
A
E
P
D
G
T
E
V
A
D
K
A
G
Site 33
Y412
R
V
K
V
G
N
E
Y
V
T
K
G
Q
N
V
Site 34
T414
K
V
G
N
E
Y
V
T
K
G
Q
N
V
Q
Q
Site 35
T451
R
I
N
Q
Q
L
D
T
K
Q
P
R
Q
Y
F
Site 36
Y457
D
T
K
Q
P
R
Q
Y
F
I
G
V
L
D
I
Site 37
T483
E
Q
L
C
I
N
F
T
N
E
K
L
Q
Q
F
Site 38
Y503
F
V
L
E
Q
E
E
Y
K
K
E
G
I
E
W
Site 39
S534
E
K
P
M
G
I
F
S
I
L
E
E
E
C
M
Site 40
S549
F
P
K
A
T
D
T
S
F
K
N
K
L
Y
D
Site 41
Y555
T
S
F
K
N
K
L
Y
D
Q
H
L
G
K
S
Site 42
S580
G
K
A
E
A
H
F
S
L
V
H
Y
A
G
T
Site 43
Y584
A
H
F
S
L
V
H
Y
A
G
T
V
D
Y
N
Site 44
Y590
H
Y
A
G
T
V
D
Y
N
I
A
G
W
L
D
Site 45
T606
N
K
D
P
L
N
E
T
V
V
G
L
Y
Q
K
Site 46
Y611
N
E
T
V
V
G
L
Y
Q
K
S
S
L
K
L
Site 47
S634
A
G
A
E
T
G
D
S
G
G
S
K
K
G
G
Site 48
S646
K
G
G
K
K
K
G
S
S
F
Q
T
V
S
A
Site 49
S647
G
G
K
K
K
G
S
S
F
Q
T
V
S
A
V
Site 50
T650
K
K
G
S
S
F
Q
T
V
S
A
V
F
R
E
Site 51
T664
E
N
L
N
K
L
M
T
N
L
R
S
T
H
P
Site 52
T669
L
M
T
N
L
R
S
T
H
P
H
F
V
R
C
Site 53
T682
R
C
L
I
P
N
E
T
K
T
P
G
V
M
D
Site 54
T684
L
I
P
N
E
T
K
T
P
G
V
M
D
H
Y
Site 55
Y691
T
P
G
V
M
D
H
Y
L
V
M
H
Q
L
R
Site 56
Y719
G
F
P
S
R
I
L
Y
A
D
F
K
Q
R
Y
Site 57
S732
R
Y
R
I
L
N
A
S
A
I
P
E
G
Q
F
Site 58
S742
P
E
G
Q
F
I
D
S
K
N
A
S
E
K
L
Site 59
S746
F
I
D
S
K
N
A
S
E
K
L
L
N
S
I
Site 60
T787
M
R
D
E
K
L
V
T
L
M
T
S
T
Q
A
Site 61
Y799
T
Q
A
V
C
R
G
Y
L
M
R
V
E
F
K
Site 62
Y820
D
S
I
F
C
I
Q
Y
N
I
R
S
F
M
N
Site 63
S846
K
I
K
P
L
L
K
S
A
E
A
E
K
E
M
Site 64
S870
T
K
E
E
L
A
R
S
E
A
R
R
K
E
L
Site 65
S883
E
L
E
E
K
M
V
S
L
L
Q
E
K
N
D
Site 66
S915
R
C
E
G
L
I
K
S
K
I
L
L
E
A
K
Site 67
S938
E
E
E
E
E
M
N
S
E
L
V
A
K
K
R
Site 68
S952
R
N
L
E
D
K
C
S
S
L
K
R
D
I
D
Site 69
S953
N
L
E
D
K
C
S
S
L
K
R
D
I
D
D
Site 70
T964
D
I
D
D
L
E
L
T
L
T
K
V
E
K
E
Site 71
T966
D
D
L
E
L
T
L
T
K
V
E
K
E
K
H
Site 72
T975
V
E
K
E
K
H
A
T
E
N
K
V
K
N
L
Site 73
T987
K
N
L
S
E
E
M
T
A
L
E
E
N
I
S
Site 74
S994
T
A
L
E
E
N
I
S
K
L
T
K
E
K
K
Site 75
S1002
K
L
T
K
E
K
K
S
L
Q
E
A
H
Q
Q
Site 76
S1066
L
E
G
D
L
K
M
S
Q
E
S
I
M
D
L
Site 77
S1092
K
K
K
E
F
E
L
S
Q
L
Q
A
R
I
D
Site 78
S1105
I
D
D
E
Q
V
H
S
L
Q
F
Q
K
K
I
Site 79
T1131
E
E
I
E
A
E
H
T
L
R
A
K
I
E
K
Site 80
S1141
A
K
I
E
K
Q
R
S
D
L
A
R
E
L
E
Site 81
S1151
A
R
E
L
E
E
I
S
E
R
L
E
E
A
S
Site 82
S1158
S
E
R
L
E
E
A
S
G
A
T
S
A
Q
I
Site 83
S1162
E
E
A
S
G
A
T
S
A
Q
I
E
M
N
K
Site 84
T1195
Q
H
E
A
T
A
A
T
L
R
K
K
Q
A
D
Site 85
S1203
L
R
K
K
Q
A
D
S
V
A
E
L
G
E
Q
Site 86
S1226
Q
K
L
E
K
E
K
S
E
L
K
M
E
I
D
Site 87
S1237
M
E
I
D
D
M
A
S
N
I
E
A
L
S
K
Site 88
S1243
A
S
N
I
E
A
L
S
K
S
K
S
N
I
E
Site 89
S1245
N
I
E
A
L
S
K
S
K
S
N
I
E
R
T
Site 90
S1247
E
A
L
S
K
S
K
S
N
I
E
R
T
C
R
Site 91
T1252
S
K
S
N
I
E
R
T
C
R
T
V
E
D
Q
Site 92
S1261
R
T
V
E
D
Q
F
S
E
I
K
A
K
D
E
Site 93
T1286
M
Q
K
A
R
L
Q
T
Q
N
G
E
L
S
H
Site 94
S1292
Q
T
Q
N
G
E
L
S
H
R
V
E
E
K
E
Site 95
S1300
H
R
V
E
E
K
E
S
L
I
S
Q
L
T
K
Site 96
S1303
E
E
K
E
S
L
I
S
Q
L
T
K
S
K
Q
Site 97
T1306
E
S
L
I
S
Q
L
T
K
S
K
Q
A
L
T
Site 98
S1308
L
I
S
Q
L
T
K
S
K
Q
A
L
T
Q
Q
Site 99
S1339
A
M
A
H
A
L
Q
S
S
R
H
D
C
D
L
Site 100
Y1351
C
D
L
L
R
E
Q
Y
E
E
E
Q
E
A
K
Site 101
S1366
A
E
L
Q
R
A
L
S
K
A
N
S
E
V
A
Site 102
S1370
R
A
L
S
K
A
N
S
E
V
A
Q
W
K
T
Site 103
T1377
S
E
V
A
Q
W
K
T
K
Y
E
T
D
A
I
Site 104
Y1379
V
A
Q
W
K
T
K
Y
E
T
D
A
I
Q
R
Site 105
T1387
E
T
D
A
I
Q
R
T
E
E
L
E
E
A
K
Site 106
T1410
E
A
E
E
K
T
E
T
A
N
S
K
C
A
S
Site 107
S1413
E
K
T
E
T
A
N
S
K
C
A
S
L
E
K
Site 108
S1417
T
A
N
S
K
C
A
S
L
E
K
T
K
Q
R
Site 109
T1421
K
C
A
S
L
E
K
T
K
Q
R
L
Q
G
E
Site 110
S1439
L
M
R
D
L
E
R
S
H
T
A
C
A
T
L
Site 111
T1441
R
D
L
E
R
S
H
T
A
C
A
T
L
D
K
Site 112
T1445
R
S
H
T
A
C
A
T
L
D
K
K
Q
R
N
Site 113
S1467
W
K
Q
K
L
D
E
S
Q
A
E
L
E
A
A
Site 114
S1478
L
E
A
A
Q
K
E
S
R
S
L
S
T
E
L
Site 115
S1480
A
A
Q
K
E
S
R
S
L
S
T
E
L
F
K
Site 116
S1482
Q
K
E
S
R
S
L
S
T
E
L
F
K
M
R
Site 117
Y1492
L
F
K
M
R
N
A
Y
E
E
V
V
D
Q
L
Site 118
T1501
E
V
V
D
Q
L
E
T
L
R
R
E
N
K
N
Site 119
S1514
K
N
L
Q
E
E
I
S
D
L
T
E
Q
I
A
Site 120
T1517
Q
E
E
I
S
D
L
T
E
Q
I
A
E
T
G
Site 121
T1533
N
L
Q
E
A
E
K
T
K
K
L
V
E
Q
E
Site 122
S1542
K
L
V
E
Q
E
K
S
D
L
Q
V
A
L
E
Site 123
S1554
A
L
E
E
V
E
G
S
L
E
H
E
E
S
K
Site 124
S1560
G
S
L
E
H
E
E
S
K
I
L
R
V
Q
L
Site 125
S1570
L
R
V
Q
L
E
L
S
Q
V
K
S
E
L
D
Site 126
S1574
L
E
L
S
Q
V
K
S
E
L
D
R
K
V
I
Site 127
S1594
I
E
Q
L
K
R
N
S
Q
R
A
A
E
A
L
Site 128
S1603
R
A
A
E
A
L
Q
S
V
L
D
A
E
I
R
Site 129
T1643
S
N
R
Q
M
A
E
T
Q
R
H
L
R
T
V
Site 130
T1649
E
T
Q
R
H
L
R
T
V
Q
G
Q
L
K
D
Site 131
S1657
V
Q
G
Q
L
K
D
S
Q
L
H
L
D
D
A
Site 132
S1706
T
E
R
T
R
R
L
S
E
Q
E
L
L
D
A
Site 133
S1714
E
Q
E
L
L
D
A
S
D
R
V
Q
L
L
H
Site 134
S1722
D
R
V
Q
L
L
H
S
Q
N
T
S
L
I
N
Site 135
S1726
L
L
H
S
Q
N
T
S
L
I
N
T
K
K
K
Site 136
S1748
C
Q
A
E
V
E
N
S
I
Q
E
S
R
N
A
Site 137
S1752
V
E
N
S
I
Q
E
S
R
N
A
E
E
K
A
Site 138
S1780
L
K
K
E
Q
D
T
S
A
H
L
E
R
M
K
Site 139
T1793
M
K
K
N
L
E
Q
T
V
K
D
L
Q
H
R
Site 140
Y1847
A
L
K
G
A
H
K
Y
E
R
K
V
K
E
M
Site 141
Y1856
R
K
V
K
E
M
T
Y
Q
A
E
E
D
R
K
Site 142
S1881
K
L
Q
A
K
V
K
S
Y
K
R
Q
A
E
E
Site 143
T1895
E
A
E
E
Q
A
N
T
Q
L
S
R
C
R
R
Site 144
S1898
E
Q
A
N
T
Q
L
S
R
C
R
R
V
Q
H
Site 145
S1919
E
R
A
D
I
A
E
S
Q
V
N
K
L
R
A
Site 146
S1928
V
N
K
L
R
A
K
S
R
D
V
G
S
Q
K
Site 147
S1933
A
K
S
R
D
V
G
S
Q
K
M
E
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation