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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF2C2
Full Name:
Eukaryotic translation initiation factor 2C 2
Alias:
AGO2; Argonaute 2; Argonaute-2; Eif2c 2; Eif-2c 2; Eukaryotic translation initiation factor 2c 2; Eukaryotic translation initiation factor 2C, 2; I2c2; PAZ Piwi domain protein; Paz piwi domain protein; Ppd; Protein slicer; Q10; Slicer protein
Type:
Translation; RNA processing
Mass (Da):
97208
Number AA:
859
UniProt ID:
Q9UKV8
International Prot ID:
IPI00220349
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016442
GO:0000932
GO:0005845
Uniprot
OncoNet
Molecular Function:
GO:0000340
GO:0070551
GO:0046872
PhosphoSite+
KinaseNET
Biological Process:
GO:0035279
GO:0035278
GO:0045947
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
P
P
P
P
I
Q
G
Y
A
F
K
P
P
P
R
Site 2
T33
P
P
R
P
D
F
G
T
S
G
R
T
I
K
L
Site 3
S34
P
R
P
D
F
G
T
S
G
R
T
I
K
L
Q
Site 4
Y55
D
I
P
K
I
D
I
Y
H
Y
E
L
D
I
K
Site 5
Y57
P
K
I
D
I
Y
H
Y
E
L
D
I
K
P
E
Site 6
Y101
F
D
G
R
K
N
L
Y
T
A
M
P
L
P
I
Site 7
T102
D
G
R
K
N
L
Y
T
A
M
P
L
P
I
G
Site 8
T118
D
K
V
E
L
E
V
T
L
P
G
E
G
K
D
Site 9
S148
Q
A
L
H
D
A
L
S
G
R
L
P
S
V
P
Site 10
Y174
R
H
L
P
S
M
R
Y
T
P
V
G
R
S
F
Site 11
T175
H
L
P
S
M
R
Y
T
P
V
G
R
S
F
F
Site 12
S180
R
Y
T
P
V
G
R
S
F
F
T
A
S
E
G
Site 13
T183
P
V
G
R
S
F
F
T
A
S
E
G
C
S
N
Site 14
S185
G
R
S
F
F
T
A
S
E
G
C
S
N
P
L
Site 15
S189
F
T
A
S
E
G
C
S
N
P
L
G
G
G
R
Site 16
S242
C
E
V
L
D
F
K
S
I
E
E
Q
Q
K
P
Site 17
T251
E
E
Q
Q
K
P
L
T
D
S
Q
R
V
K
F
Site 18
S253
Q
Q
K
P
L
T
D
S
Q
R
V
K
F
T
K
Site 19
T270
K
G
L
K
V
E
I
T
H
C
G
Q
M
K
R
Site 20
Y279
C
G
Q
M
K
R
K
Y
R
V
C
N
V
T
R
Site 21
T285
K
Y
R
V
C
N
V
T
R
R
P
A
S
H
Q
Site 22
S290
N
V
T
R
R
P
A
S
H
Q
T
F
P
L
Q
Site 23
T293
R
R
P
A
S
H
Q
T
F
P
L
Q
Q
E
S
Site 24
T303
L
Q
Q
E
S
G
Q
T
V
E
C
T
V
A
Q
Site 25
T307
S
G
Q
T
V
E
C
T
V
A
Q
Y
F
K
D
Site 26
Y311
V
E
C
T
V
A
Q
Y
F
K
D
R
H
K
L
Site 27
Y322
R
H
K
L
V
L
R
Y
P
H
L
P
C
L
Q
Site 28
T337
V
G
Q
E
Q
K
H
T
Y
L
P
L
E
V
C
Site 29
Y338
G
Q
E
Q
K
H
T
Y
L
P
L
E
V
C
N
Site 30
T357
Q
R
C
I
K
K
L
T
D
N
Q
T
S
T
M
Site 31
T361
K
K
L
T
D
N
Q
T
S
T
M
I
R
A
T
Site 32
T363
L
T
D
N
Q
T
S
T
M
I
R
A
T
A
R
Site 33
T368
T
S
T
M
I
R
A
T
A
R
S
A
P
D
R
Site 34
S371
M
I
R
A
T
A
R
S
A
P
D
R
Q
E
E
Site 35
S380
P
D
R
Q
E
E
I
S
K
L
M
R
S
A
S
Site 36
S385
E
I
S
K
L
M
R
S
A
S
F
N
T
D
P
Site 37
S387
S
K
L
M
R
S
A
S
F
N
T
D
P
Y
V
Site 38
Y393
A
S
F
N
T
D
P
Y
V
R
E
F
G
I
M
Site 39
T409
K
D
E
M
T
D
V
T
G
R
V
L
Q
P
P
Site 40
S417
G
R
V
L
Q
P
P
S
I
L
Y
G
G
R
N
Site 41
T429
G
R
N
K
A
I
A
T
P
V
Q
G
V
W
D
Site 42
T463
F
A
P
Q
R
Q
C
T
E
V
H
L
K
S
F
Site 43
S469
C
T
E
V
H
L
K
S
F
T
E
Q
L
R
K
Site 44
S478
T
E
Q
L
R
K
I
S
R
D
A
G
M
P
I
Site 45
Y494
G
Q
P
C
F
C
K
Y
A
Q
G
A
D
S
V
Site 46
S500
K
Y
A
Q
G
A
D
S
V
E
P
M
F
R
H
Site 47
Y529
L
P
G
K
T
P
V
Y
A
E
V
K
R
V
G
Site 48
T538
E
V
K
R
V
G
D
T
V
L
G
M
A
T
Q
Site 49
T556
M
K
N
V
Q
R
T
T
P
Q
T
L
S
N
L
Site 50
T559
V
Q
R
T
T
P
Q
T
L
S
N
L
C
L
K
Site 51
S561
R
T
T
P
Q
T
L
S
N
L
C
L
K
I
N
Site 52
Y654
R
E
L
L
I
Q
F
Y
K
S
T
R
F
K
P
Site 53
S656
L
L
I
Q
F
Y
K
S
T
R
F
K
P
T
R
Site 54
Y698
C
I
K
L
E
K
D
Y
Q
P
G
I
T
F
I
Site 55
T703
K
D
Y
Q
P
G
I
T
F
I
V
V
Q
K
R
Site 56
T713
V
V
Q
K
R
H
H
T
R
L
F
C
T
D
K
Site 57
Y749
H
P
T
E
F
D
F
Y
L
C
S
H
A
G
I
Site 58
T759
S
H
A
G
I
Q
G
T
S
R
P
S
H
Y
H
Site 59
S775
L
W
D
D
N
R
F
S
S
D
E
L
Q
I
L
Site 60
S776
W
D
D
N
R
F
S
S
D
E
L
Q
I
L
T
Site 61
T783
S
D
E
L
Q
I
L
T
Y
Q
L
C
H
T
Y
Site 62
T789
L
T
Y
Q
L
C
H
T
Y
V
R
C
T
R
S
Site 63
Y790
T
Y
Q
L
C
H
T
Y
V
R
C
T
R
S
V
Site 64
S798
V
R
C
T
R
S
V
S
I
P
A
P
A
Y
Y
Site 65
Y815
L
V
A
F
R
A
R
Y
H
L
V
D
K
E
H
Site 66
S824
L
V
D
K
E
H
D
S
A
E
G
S
H
T
S
Site 67
S828
E
H
D
S
A
E
G
S
H
T
S
G
Q
S
N
Site 68
T830
D
S
A
E
G
S
H
T
S
G
Q
S
N
G
R
Site 69
S831
S
A
E
G
S
H
T
S
G
Q
S
N
G
R
D
Site 70
T852
A
V
Q
V
H
Q
D
T
L
R
T
M
Y
F
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation