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Updated November 2019
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Protein Info
Short Name:
ACIN1
Full Name:
Apoptotic chromatin condensation inducer in the nucleus
Alias:
ACIN; ACINU; ACINUS; Acinus; Apoptotic chromatin condensation inducer 1; Apoptotic chromatin condensation inducer in the nucleus; FSAP152; Functional spliceosome-associated protein 152; KIAA0670
Type:
Chromatin protein, condensation
Mass (Da):
151888
Number AA:
1341
UniProt ID:
Q9UKV3
International Prot ID:
IPI00007334
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016887
GO:0019899
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0030263
GO:0030218
GO:0045657
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
W
R
R
K
H
P
R
T
S
G
G
T
R
G
V
Site 2
S10
R
R
K
H
P
R
T
S
G
G
T
R
G
V
L
Site 3
S18
G
G
T
R
G
V
L
S
G
N
R
G
V
E
Y
Site 4
Y25
S
G
N
R
G
V
E
Y
G
S
G
R
G
H
L
Site 5
S27
N
R
G
V
E
Y
G
S
G
R
G
H
L
G
T
Site 6
T34
S
G
R
G
H
L
G
T
F
E
G
R
W
R
K
Site 7
T51
K
M
P
E
A
V
G
T
D
P
S
T
S
R
K
Site 8
S54
E
A
V
G
T
D
P
S
T
S
R
K
M
A
E
Site 9
T55
A
V
G
T
D
P
S
T
S
R
K
M
A
E
L
Site 10
S56
V
G
T
D
P
S
T
S
R
K
M
A
E
L
E
Site 11
S92
E
Q
R
G
L
A
K
S
G
Q
K
S
A
L
V
Site 12
S96
L
A
K
S
G
Q
K
S
A
L
V
K
R
L
K
Site 13
S115
L
E
N
L
Q
K
H
S
T
P
H
A
A
F
Q
Site 14
T116
E
N
L
Q
K
H
S
T
P
H
A
A
F
Q
P
Site 15
S125
H
A
A
F
Q
P
N
S
Q
I
G
E
E
M
S
Site 16
S132
S
Q
I
G
E
E
M
S
Q
N
S
F
I
K
Q
Site 17
S135
G
E
E
M
S
Q
N
S
F
I
K
Q
Y
L
E
Site 18
Y140
Q
N
S
F
I
K
Q
Y
L
E
K
Q
Q
E
L
Site 19
S166
A
A
E
L
E
E
A
S
A
E
S
E
D
E
M
Site 20
S169
L
E
E
A
S
A
E
S
E
D
E
M
I
H
P
Site 21
S181
I
H
P
E
G
V
A
S
L
L
P
P
D
F
Q
Site 22
S189
L
L
P
P
D
F
Q
S
S
L
E
R
P
E
L
Site 23
S190
L
P
P
D
F
Q
S
S
L
E
R
P
E
L
E
Site 24
S199
E
R
P
E
L
E
L
S
R
H
S
P
R
K
S
Site 25
S202
E
L
E
L
S
R
H
S
P
R
K
S
S
S
I
Site 26
S206
S
R
H
S
P
R
K
S
S
S
I
S
E
E
K
Site 27
S207
R
H
S
P
R
K
S
S
S
I
S
E
E
K
G
Site 28
S208
H
S
P
R
K
S
S
S
I
S
E
E
K
G
D
Site 29
S210
P
R
K
S
S
S
I
S
E
E
K
G
D
S
D
Site 30
S216
I
S
E
E
K
G
D
S
D
D
E
K
P
R
K
Site 31
S228
P
R
K
G
E
R
R
S
S
R
V
R
Q
A
R
Site 32
S229
R
K
G
E
R
R
S
S
R
V
R
Q
A
R
A
Site 33
S240
Q
A
R
A
A
K
L
S
E
G
S
Q
P
A
E
Site 34
S243
A
A
K
L
S
E
G
S
Q
P
A
E
E
E
E
Site 35
T254
E
E
E
E
D
Q
E
T
P
S
R
N
L
R
V
Site 36
S256
E
E
D
Q
E
T
P
S
R
N
L
R
V
R
A
Site 37
T269
R
A
D
R
N
L
K
T
E
E
E
E
E
E
E
Site 38
S295
G
D
D
E
G
Q
K
S
R
E
A
P
I
L
K
Site 39
T326
M
M
D
E
R
P
K
T
R
S
Q
E
Q
E
V
Site 40
S328
D
E
R
P
K
T
R
S
Q
E
Q
E
V
L
E
Site 41
T341
L
E
R
G
G
R
F
T
R
S
Q
E
E
A
R
Site 42
S343
R
G
G
R
F
T
R
S
Q
E
E
A
R
K
S
Site 43
S350
S
Q
E
E
A
R
K
S
H
L
A
R
Q
Q
Q
Site 44
T363
Q
Q
E
K
E
M
K
T
T
S
P
L
E
E
E
Site 45
T364
Q
E
K
E
M
K
T
T
S
P
L
E
E
E
E
Site 46
S365
E
K
E
M
K
T
T
S
P
L
E
E
E
E
R
Site 47
S376
E
E
E
R
E
I
K
S
S
Q
G
L
K
E
K
Site 48
S377
E
E
R
E
I
K
S
S
Q
G
L
K
E
K
S
Site 49
S384
S
Q
G
L
K
E
K
S
K
S
P
S
P
P
R
Site 50
S386
G
L
K
E
K
S
K
S
P
S
P
P
R
L
T
Site 51
S388
K
E
K
S
K
S
P
S
P
P
R
L
T
E
D
Site 52
T393
S
P
S
P
P
R
L
T
E
D
R
K
K
A
S
Site 53
S400
T
E
D
R
K
K
A
S
L
V
A
L
P
E
Q
Site 54
T408
L
V
A
L
P
E
Q
T
A
S
E
E
E
T
P
Site 55
S410
A
L
P
E
Q
T
A
S
E
E
E
T
P
P
P
Site 56
T414
Q
T
A
S
E
E
E
T
P
P
P
L
L
T
K
Site 57
T420
E
T
P
P
P
L
L
T
K
E
A
S
S
P
P
Site 58
S424
P
L
L
T
K
E
A
S
S
P
P
P
H
P
Q
Site 59
S425
P
L
L
T
K
E
A
S
S
P
P
P
H
P
Q
Site 60
S434
P
P
H
P
Q
L
H
S
E
E
E
I
E
P
M
Site 61
S453
P
P
V
L
I
Q
L
S
P
P
N
T
D
A
D
Site 62
T457
I
Q
L
S
P
P
N
T
D
A
D
T
R
E
L
Site 63
T461
P
P
N
T
D
A
D
T
R
E
L
L
V
S
Q
Site 64
S467
D
T
R
E
L
L
V
S
Q
H
T
V
Q
L
V
Site 65
S478
V
Q
L
V
G
G
L
S
P
L
S
S
P
S
D
Site 66
S481
V
G
G
L
S
P
L
S
S
P
S
D
T
K
A
Site 67
S482
G
G
L
S
P
L
S
S
P
S
D
T
K
A
E
Site 68
S484
L
S
P
L
S
S
P
S
D
T
K
A
E
S
P
Site 69
T486
P
L
S
S
P
S
D
T
K
A
E
S
P
A
E
Site 70
S490
P
S
D
T
K
A
E
S
P
A
E
K
V
P
E
Site 71
S499
A
E
K
V
P
E
E
S
V
L
P
L
V
Q
K
Site 72
T508
L
P
L
V
Q
K
S
T
L
A
D
Y
S
A
Q
Site 73
Y512
Q
K
S
T
L
A
D
Y
S
A
Q
K
D
L
E
Site 74
S513
K
S
T
L
A
D
Y
S
A
Q
K
D
L
E
P
Site 75
S522
Q
K
D
L
E
P
E
S
D
R
S
A
Q
P
L
Site 76
S525
L
E
P
E
S
D
R
S
A
Q
P
L
P
L
K
Site 77
S551
E
E
C
L
K
Q
P
S
L
E
Q
K
E
G
R
Site 78
S561
Q
K
E
G
R
R
A
S
H
T
L
L
P
S
H
Site 79
T563
E
G
R
R
A
S
H
T
L
L
P
S
H
R
L
Site 80
S567
A
S
H
T
L
L
P
S
H
R
L
K
Q
S
A
Site 81
S573
P
S
H
R
L
K
Q
S
A
D
S
S
S
S
R
Site 82
S576
R
L
K
Q
S
A
D
S
S
S
S
R
S
S
S
Site 83
S577
L
K
Q
S
A
D
S
S
S
S
R
S
S
S
S
Site 84
S578
K
Q
S
A
D
S
S
S
S
R
S
S
S
S
S
Site 85
S579
Q
S
A
D
S
S
S
S
R
S
S
S
S
S
S
Site 86
S581
A
D
S
S
S
S
R
S
S
S
S
S
S
S
S
Site 87
S582
D
S
S
S
S
R
S
S
S
S
S
S
S
S
S
Site 88
S583
S
S
S
S
R
S
S
S
S
S
S
S
S
S
R
Site 89
S584
S
S
S
R
S
S
S
S
S
S
S
S
S
R
S
Site 90
S585
S
S
R
S
S
S
S
S
S
S
S
S
R
S
R
Site 91
S586
S
R
S
S
S
S
S
S
S
S
S
R
S
R
S
Site 92
S587
R
S
S
S
S
S
S
S
S
S
R
S
R
S
R
Site 93
S588
S
S
S
S
S
S
S
S
S
R
S
R
S
R
S
Site 94
S589
S
S
S
S
S
S
S
S
R
S
R
S
R
S
P
Site 95
S591
S
S
S
S
S
S
R
S
R
S
R
S
P
D
S
Site 96
S593
S
S
S
S
R
S
R
S
R
S
P
D
S
S
G
Site 97
S595
S
S
R
S
R
S
R
S
P
D
S
S
G
S
R
Site 98
S598
S
R
S
R
S
P
D
S
S
G
S
R
S
H
S
Site 99
S599
R
S
R
S
P
D
S
S
G
S
R
S
H
S
P
Site 100
S601
R
S
P
D
S
S
G
S
R
S
H
S
P
L
R
Site 101
S603
P
D
S
S
G
S
R
S
H
S
P
L
R
S
K
Site 102
S605
S
S
G
S
R
S
H
S
P
L
R
S
K
Q
R
Site 103
S609
R
S
H
S
P
L
R
S
K
Q
R
D
V
A
Q
Site 104
S631
R
G
R
P
K
M
G
S
R
S
T
S
E
S
R
Site 105
S633
R
P
K
M
G
S
R
S
T
S
E
S
R
S
R
Site 106
T634
P
K
M
G
S
R
S
T
S
E
S
R
S
R
S
Site 107
S635
K
M
G
S
R
S
T
S
E
S
R
S
R
S
R
Site 108
S637
G
S
R
S
T
S
E
S
R
S
R
S
R
S
R
Site 109
S639
R
S
T
S
E
S
R
S
R
S
R
S
R
S
R
Site 110
S641
T
S
E
S
R
S
R
S
R
S
R
S
R
S
A
Site 111
S643
E
S
R
S
R
S
R
S
R
S
R
S
A
S
S
Site 112
S645
R
S
R
S
R
S
R
S
R
S
A
S
S
N
S
Site 113
S647
R
S
R
S
R
S
R
S
A
S
S
N
S
R
K
Site 114
S649
R
S
R
S
R
S
A
S
S
N
S
R
K
S
L
Site 115
S650
S
R
S
R
S
A
S
S
N
S
R
K
S
L
S
Site 116
S652
S
R
S
A
S
S
N
S
R
K
S
L
S
P
G
Site 117
S655
A
S
S
N
S
R
K
S
L
S
P
G
V
S
R
Site 118
S657
S
N
S
R
K
S
L
S
P
G
V
S
R
D
S
Site 119
S661
K
S
L
S
P
G
V
S
R
D
S
S
T
S
Y
Site 120
S664
S
P
G
V
S
R
D
S
S
T
S
Y
T
E
T
Site 121
S665
P
G
V
S
R
D
S
S
T
S
Y
T
E
T
K
Site 122
T666
G
V
S
R
D
S
S
T
S
Y
T
E
T
K
D
Site 123
S667
V
S
R
D
S
S
T
S
Y
T
E
T
K
D
P
Site 124
Y668
S
R
D
S
S
T
S
Y
T
E
T
K
D
P
S
Site 125
T669
R
D
S
S
T
S
Y
T
E
T
K
D
P
S
S
Site 126
T671
S
S
T
S
Y
T
E
T
K
D
P
S
S
G
Q
Site 127
S676
T
E
T
K
D
P
S
S
G
Q
E
V
A
T
P
Site 128
T682
S
S
G
Q
E
V
A
T
P
P
V
P
Q
L
Q
Site 129
T697
V
C
E
P
K
E
R
T
S
T
S
S
S
S
V
Site 130
S698
C
E
P
K
E
R
T
S
T
S
S
S
S
V
Q
Site 131
T699
E
P
K
E
R
T
S
T
S
S
S
S
V
Q
A
Site 132
S700
P
K
E
R
T
S
T
S
S
S
S
V
Q
A
R
Site 133
S701
K
E
R
T
S
T
S
S
S
S
V
Q
A
R
R
Site 134
S702
E
R
T
S
T
S
S
S
S
V
Q
A
R
R
L
Site 135
S703
R
T
S
T
S
S
S
S
V
Q
A
R
R
L
S
Site 136
S710
S
V
Q
A
R
R
L
S
Q
P
E
S
A
E
K
Site 137
S714
R
R
L
S
Q
P
E
S
A
E
K
H
V
T
Q
Site 138
T720
E
S
A
E
K
H
V
T
Q
R
L
Q
P
E
R
Site 139
S729
R
L
Q
P
E
R
G
S
P
K
K
C
E
A
E
Site 140
T744
E
A
E
P
P
A
A
T
Q
P
Q
T
S
E
T
Site 141
T748
P
A
A
T
Q
P
Q
T
S
E
T
Q
T
S
H
Site 142
S749
A
A
T
Q
P
Q
T
S
E
T
Q
T
S
H
L
Site 143
T751
T
Q
P
Q
T
S
E
T
Q
T
S
H
L
P
E
Site 144
S754
Q
T
S
E
T
Q
T
S
H
L
P
E
S
E
R
Site 145
S759
Q
T
S
H
L
P
E
S
E
R
I
H
H
T
V
Site 146
T765
E
S
E
R
I
H
H
T
V
E
E
K
E
E
V
Site 147
T776
K
E
E
V
T
M
D
T
S
E
N
R
P
E
N
Site 148
S797
M
P
I
A
D
Q
V
S
N
D
D
R
P
E
G
Site 149
S805
N
D
D
R
P
E
G
S
V
E
D
E
E
K
K
Site 150
S814
E
D
E
E
K
K
E
S
S
L
P
K
S
F
K
Site 151
S815
D
E
E
K
K
E
S
S
L
P
K
S
F
K
R
Site 152
S819
K
E
S
S
L
P
K
S
F
K
R
K
I
S
V
Site 153
S825
K
S
F
K
R
K
I
S
V
V
S
A
T
K
G
Site 154
T830
K
I
S
V
V
S
A
T
K
G
V
P
A
G
N
Site 155
S838
K
G
V
P
A
G
N
S
D
T
E
G
G
Q
P
Site 156
T840
V
P
A
G
N
S
D
T
E
G
G
Q
P
G
R
Site 157
S854
R
K
R
R
W
G
A
S
T
A
T
T
Q
K
K
Site 158
T855
K
R
R
W
G
A
S
T
A
T
T
Q
K
K
P
Site 159
T858
W
G
A
S
T
A
T
T
Q
K
K
P
S
I
S
Site 160
S863
A
T
T
Q
K
K
P
S
I
S
I
T
T
E
S
Site 161
S865
T
Q
K
K
P
S
I
S
I
T
T
E
S
L
K
Site 162
T867
K
K
P
S
I
S
I
T
T
E
S
L
K
S
L
Site 163
S873
I
T
T
E
S
L
K
S
L
I
P
D
I
K
P
Site 164
S895
V
D
L
H
A
D
D
S
R
I
S
E
D
E
T
Site 165
S898
H
A
D
D
S
R
I
S
E
D
E
T
E
R
N
Site 166
T902
S
R
I
S
E
D
E
T
E
R
N
G
D
D
G
Site 167
T910
E
R
N
G
D
D
G
T
H
D
K
G
L
K
I
Site 168
T976
K
K
V
T
L
G
D
T
L
T
R
R
S
I
S
Site 169
T978
V
T
L
G
D
T
L
T
R
R
S
I
S
Q
Q
Site 170
S981
G
D
T
L
T
R
R
S
I
S
Q
Q
K
S
G
Site 171
S983
T
L
T
R
R
S
I
S
Q
Q
K
S
G
V
S
Site 172
S987
R
S
I
S
Q
Q
K
S
G
V
S
I
T
I
D
Site 173
S990
S
Q
Q
K
S
G
V
S
I
T
I
D
D
P
V
Site 174
T992
Q
K
S
G
V
S
I
T
I
D
D
P
V
R
T
Site 175
S1004
V
R
T
A
Q
V
P
S
P
P
R
G
K
I
S
Site 176
S1011
S
P
P
R
G
K
I
S
N
I
V
H
I
S
N
Site 177
T1024
S
N
L
V
R
P
F
T
L
G
Q
L
K
E
L
Site 178
T1058
H
C
F
V
T
Y
S
T
V
E
E
A
V
A
T
Site 179
Y1086
P
K
F
L
C
A
D
Y
A
E
Q
D
E
L
D
Site 180
Y1094
A
E
Q
D
E
L
D
Y
H
R
G
L
L
V
D
Site 181
S1104
G
L
L
V
D
R
P
S
E
T
K
T
E
E
Q
Site 182
T1108
D
R
P
S
E
T
K
T
E
E
Q
G
I
P
R
Site 183
T1159
E
M
E
R
R
E
R
T
R
S
E
R
E
W
D
Site 184
S1161
E
R
R
E
R
T
R
S
E
R
E
W
D
R
D
Site 185
S1176
K
V
R
E
G
P
R
S
R
S
R
S
R
D
R
Site 186
S1178
R
E
G
P
R
S
R
S
R
S
R
D
R
R
R
Site 187
S1180
G
P
R
S
R
S
R
S
R
D
R
R
R
K
E
Site 188
S1191
R
R
K
E
R
A
K
S
K
E
K
K
S
E
K
Site 189
S1196
A
K
S
K
E
K
K
S
E
K
K
E
K
A
Q
Site 190
T1218
L
D
D
L
F
R
K
T
K
A
A
P
C
I
Y
Site 191
Y1225
T
K
A
A
P
C
I
Y
W
L
P
L
T
D
S
Site 192
T1230
C
I
Y
W
L
P
L
T
D
S
Q
I
V
Q
K
Site 193
S1232
Y
W
L
P
L
T
D
S
Q
I
V
Q
K
E
A
Site 194
S1284
R
E
K
R
R
E
H
S
R
E
R
D
R
E
R
Site 195
T1321
R
E
R
D
R
R
D
T
K
R
H
S
R
S
R
Site 196
S1325
R
R
D
T
K
R
H
S
R
S
R
S
R
S
T
Site 197
S1327
D
T
K
R
H
S
R
S
R
S
R
S
T
P
V
Site 198
S1329
K
R
H
S
R
S
R
S
R
S
T
P
V
R
D
Site 199
S1331
H
S
R
S
R
S
R
S
T
P
V
R
D
R
G
Site 200
T1332
S
R
S
R
S
R
S
T
P
V
R
D
R
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation