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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANAPC4
Full Name:
Anaphase-promoting complex subunit 4
Alias:
Anaphase-promoting complex subunit 4: Cyclosome subunit 4; Cyclosome subunit 4
Type:
Ubiquitin conjugating protein
Mass (Da):
92116
Number AA:
808
UniProt ID:
Q9UJX5
International Prot ID:
IPI00002551
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
GO:0005829
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0004842
GO:0004842
GO:0016874
PhosphoSite+
KinaseNET
Biological Process:
GO:0000086
GO:0031145
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
F
P
T
C
F
P
S
F
R
V
V
G
E
K
Site 2
S57
A
S
F
H
R
V
W
S
F
P
P
N
E
N
T
Site 3
T87
L
A
F
A
L
A
D
T
K
K
I
V
L
C
D
Site 4
S100
C
D
V
E
K
P
E
S
L
H
S
F
S
V
E
Site 5
S103
E
K
P
E
S
L
H
S
F
S
V
E
A
P
V
Site 6
S105
P
E
S
L
H
S
F
S
V
E
A
P
V
S
C
Site 7
S127
V
E
S
S
V
L
T
S
F
Y
N
A
E
D
E
Site 8
Y129
S
S
V
L
T
S
F
Y
N
A
E
D
E
S
N
Site 9
T144
L
L
L
P
K
L
P
T
L
P
K
N
Y
S
N
Site 10
S150
P
T
L
P
K
N
Y
S
N
T
S
K
I
F
S
Site 11
S157
S
N
T
S
K
I
F
S
E
E
N
S
D
E
I
Site 12
S161
K
I
F
S
E
E
N
S
D
E
I
I
K
L
L
Site 13
S218
S
S
D
L
K
S
L
S
V
V
T
E
V
S
T
Site 14
Y233
N
G
A
S
E
V
S
Y
F
Q
L
E
T
N
L
Site 15
T256
T
R
M
A
R
K
F
T
H
I
S
A
L
L
Q
Site 16
S285
E
I
L
M
Q
M
D
S
R
L
T
K
F
V
Q
Site 17
T288
M
Q
M
D
S
R
L
T
K
F
V
Q
E
K
N
Site 18
T297
F
V
Q
E
K
N
T
T
T
S
V
Q
D
E
F
Site 19
S336
G
L
K
K
L
G
Q
S
I
E
S
S
Y
S
S
Site 20
S339
K
L
G
Q
S
I
E
S
S
Y
S
S
I
Q
K
Site 21
S340
L
G
Q
S
I
E
S
S
Y
S
S
I
Q
K
L
Site 22
S342
Q
S
I
E
S
S
Y
S
S
I
Q
K
L
V
I
Site 23
S343
S
I
E
S
S
Y
S
S
I
Q
K
L
V
I
S
Site 24
S350
S
I
Q
K
L
V
I
S
H
L
Q
S
G
S
E
Site 25
S356
I
S
H
L
Q
S
G
S
E
S
L
L
Y
H
L
Site 26
S358
H
L
Q
S
G
S
E
S
L
L
Y
H
L
S
E
Site 27
Y361
S
G
S
E
S
L
L
Y
H
L
S
E
L
K
G
Site 28
S364
E
S
L
L
Y
H
L
S
E
L
K
G
M
A
S
Site 29
S371
S
E
L
K
G
M
A
S
W
K
Q
K
Y
E
P
Site 30
Y376
M
A
S
W
K
Q
K
Y
E
P
L
G
L
D
A
Site 31
S409
E
L
L
Q
V
I
D
S
S
M
K
N
F
K
A
Site 32
T429
Y
V
A
M
L
R
M
T
E
D
H
V
L
P
E
Site 33
Y463
F
N
E
A
P
D
L
Y
N
R
K
G
K
Y
F
Site 34
Y469
L
Y
N
R
K
G
K
Y
F
N
V
E
R
V
G
Site 35
S488
D
E
D
D
D
L
V
S
P
P
N
T
E
G
N
Site 36
T492
D
L
V
S
P
P
N
T
E
G
N
Q
W
Y
D
Site 37
S505
Y
D
F
L
Q
N
S
S
H
L
K
E
S
P
L
Site 38
S510
N
S
S
H
L
K
E
S
P
L
L
F
P
Y
Y
Site 39
Y516
E
S
P
L
L
F
P
Y
Y
P
R
K
S
L
H
Site 40
Y517
S
P
L
L
F
P
Y
Y
P
R
K
S
L
H
F
Site 41
S521
F
P
Y
Y
P
R
K
S
L
H
F
V
K
R
R
Site 42
Y557
Q
A
I
C
I
P
L
Y
R
D
T
R
S
E
D
Site 43
T560
C
I
P
L
Y
R
D
T
R
S
E
D
S
T
R
Site 44
S562
P
L
Y
R
D
T
R
S
E
D
S
T
R
R
L
Site 45
S565
R
D
T
R
S
E
D
S
T
R
R
L
F
K
F
Site 46
T566
D
T
R
S
E
D
S
T
R
R
L
F
K
F
P
Site 47
T580
P
F
L
W
N
N
K
T
S
N
L
H
Y
L
L
Site 48
T605
M
C
I
L
R
R
H
T
D
I
S
Q
S
V
S
Site 49
S608
L
R
R
H
T
D
I
S
Q
S
V
S
N
G
L
Site 50
S610
R
H
T
D
I
S
Q
S
V
S
N
G
L
I
A
Site 51
S634
T
T
E
K
V
R
R
S
I
Y
S
C
L
D
A
Site 52
Y636
E
K
V
R
R
S
I
Y
S
C
L
D
A
Q
F
Site 53
S637
K
V
R
R
S
I
Y
S
C
L
D
A
Q
F
Y
Site 54
Y644
S
C
L
D
A
Q
F
Y
D
D
E
T
V
T
V
Site 55
T648
A
Q
F
Y
D
D
E
T
V
T
V
V
L
K
D
Site 56
T656
V
T
V
V
L
K
D
T
V
G
R
E
G
R
D
Site 57
Y683
N
S
E
D
S
A
E
Y
Q
F
T
G
T
Y
S
Site 58
T686
D
S
A
E
Y
Q
F
T
G
T
Y
S
T
R
L
Site 59
S698
T
R
L
D
E
Q
C
S
A
I
P
T
R
T
M
Site 60
T702
E
Q
C
S
A
I
P
T
R
T
M
H
F
E
K
Site 61
Y721
L
E
S
M
K
A
Q
Y
V
A
G
N
G
F
R
Site 62
S731
G
N
G
F
R
K
V
S
C
V
L
S
S
N
L
Site 63
S735
R
K
V
S
C
V
L
S
S
N
L
R
H
V
R
Site 64
S757
D
E
W
E
L
D
E
S
S
D
E
E
E
E
A
Site 65
S758
E
W
E
L
D
E
S
S
D
E
E
E
E
A
S
Site 66
S765
S
D
E
E
E
E
A
S
N
K
P
V
K
I
K
Site 67
S777
K
I
K
E
E
V
L
S
E
S
E
A
E
N
Q
Site 68
S779
K
E
E
V
L
S
E
S
E
A
E
N
Q
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation