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Updated November 2019
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Protein Info
Short Name:
RASAL2
Full Name:
RAS GTPASE-ACTIVATING PROTEIN NGAP.
Alias:
NGAP; Ras GTPase activating protein-like; Ras GTPase-activating protein nGAP; Ras protein activator like 1; RAS protein activator like 2; RAS protein activator-like 1; RAS protein activator-like 2
Type:
GTPase activating protein, Ras
Mass (Da):
128558
Number AA:
1139
UniProt ID:
Q9UJF2
International Prot ID:
IPI00006854
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005099
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
E
V
P
A
E
R
S
P
R
R
R
S
I
S
Site 2
S16
E
R
S
P
R
R
R
S
I
S
G
T
S
T
S
Site 3
S18
S
P
R
R
R
S
I
S
G
T
S
T
S
E
K
Site 4
T20
R
R
R
S
I
S
G
T
S
T
S
E
K
P
N
Site 5
S21
R
R
S
I
S
G
T
S
T
S
E
K
P
N
S
Site 6
T22
R
S
I
S
G
T
S
T
S
E
K
P
N
S
M
Site 7
S23
S
I
S
G
T
S
T
S
E
K
P
N
S
M
D
Site 8
S28
S
T
S
E
K
P
N
S
M
D
T
A
N
T
S
Site 9
T31
E
K
P
N
S
M
D
T
A
N
T
S
P
F
K
Site 10
T34
N
S
M
D
T
A
N
T
S
P
F
K
V
P
G
Site 11
S35
S
M
D
T
A
N
T
S
P
F
K
V
P
G
F
Site 12
S44
F
K
V
P
G
F
F
S
K
R
L
K
G
S
I
Site 13
S50
F
S
K
R
L
K
G
S
I
K
R
T
K
S
Q
Site 14
T54
L
K
G
S
I
K
R
T
K
S
Q
S
K
L
D
Site 15
S56
G
S
I
K
R
T
K
S
Q
S
K
L
D
R
N
Site 16
S58
I
K
R
T
K
S
Q
S
K
L
D
R
N
T
S
Site 17
T64
Q
S
K
L
D
R
N
T
S
F
R
L
P
S
L
Site 18
S65
S
K
L
D
R
N
T
S
F
R
L
P
S
L
R
Site 19
S70
N
T
S
F
R
L
P
S
L
R
S
T
D
D
R
Site 20
S73
F
R
L
P
S
L
R
S
T
D
D
R
S
R
G
Site 21
T74
R
L
P
S
L
R
S
T
D
D
R
S
R
G
L
Site 22
S78
L
R
S
T
D
D
R
S
R
G
L
P
K
L
K
Site 23
S87
G
L
P
K
L
K
E
S
R
S
H
E
S
L
L
Site 24
S89
P
K
L
K
E
S
R
S
H
E
S
L
L
S
P
Site 25
S92
K
E
S
R
S
H
E
S
L
L
S
P
C
S
T
Site 26
S95
R
S
H
E
S
L
L
S
P
C
S
T
V
E
C
Site 27
S112
L
G
R
G
E
P
V
S
V
K
P
L
H
S
S
Site 28
S135
E
V
T
Y
L
S
G
S
K
C
F
S
C
N
S
Site 29
S139
L
S
G
S
K
C
F
S
C
N
S
A
S
E
R
Site 30
S142
S
K
C
F
S
C
N
S
A
S
E
R
D
K
W
Site 31
T156
W
M
E
N
L
R
R
T
V
Q
P
N
K
D
N
Site 32
Y187
D
L
A
P
K
K
K
Y
F
C
E
L
C
L
D
Site 33
T202
D
T
L
F
A
R
T
T
S
K
T
K
A
D
N
Site 34
S203
T
L
F
A
R
T
T
S
K
T
K
A
D
N
I
Site 35
T205
F
A
R
T
T
S
K
T
K
A
D
N
I
F
W
Site 36
S220
G
E
H
F
E
F
F
S
L
P
P
L
H
S
I
Site 37
Y232
H
S
I
T
V
H
I
Y
K
D
V
E
K
K
K
Site 38
Y246
K
K
K
D
K
N
N
Y
V
G
L
V
N
I
P
Site 39
T258
N
I
P
T
A
S
V
T
G
R
Q
F
V
E
K
Site 40
Y267
R
Q
F
V
E
K
W
Y
P
V
S
T
P
T
P
Site 41
S270
V
E
K
W
Y
P
V
S
T
P
T
P
N
K
G
Site 42
T271
E
K
W
Y
P
V
S
T
P
T
P
N
K
G
K
Site 43
T273
W
Y
P
V
S
T
P
T
P
N
K
G
K
T
G
Site 44
T279
P
T
P
N
K
G
K
T
G
G
P
S
I
R
I
Site 45
S283
K
G
K
T
G
G
P
S
I
R
I
K
S
R
F
Site 46
S288
G
P
S
I
R
I
K
S
R
F
Q
T
I
T
I
Site 47
T292
R
I
K
S
R
F
Q
T
I
T
I
L
P
M
E
Site 48
T294
K
S
R
F
Q
T
I
T
I
L
P
M
E
Q
Y
Site 49
Y301
T
I
L
P
M
E
Q
Y
K
E
F
A
E
F
V
Site 50
S324
S
V
L
E
P
V
I
S
V
R
N
K
E
E
L
Site 51
S377
E
N
T
I
A
T
K
S
I
E
E
Y
L
K
L
Site 52
Y381
A
T
K
S
I
E
E
Y
L
K
L
V
G
Q
Q
Site 53
Y389
L
K
L
V
G
Q
Q
Y
L
H
D
A
L
G
E
Site 54
Y402
G
E
F
I
K
A
L
Y
E
S
D
E
N
C
E
Site 55
S413
E
N
C
E
V
D
P
S
K
C
S
S
S
E
L
Site 56
S417
V
D
P
S
K
C
S
S
S
E
L
I
D
H
Q
Site 57
S418
D
P
S
K
C
S
S
S
E
L
I
D
H
Q
S
Site 58
S469
N
R
G
K
Q
D
I
S
E
R
L
I
S
A
S
Site 59
Y498
L
F
N
L
M
Q
E
Y
P
D
D
R
T
S
R
Site 60
T503
Q
E
Y
P
D
D
R
T
S
R
T
L
T
L
I
Site 61
S504
E
Y
P
D
D
R
T
S
R
T
L
T
L
I
A
Site 62
T508
D
R
T
S
R
T
L
T
L
I
A
K
V
I
Q
Site 63
Y529
K
F
G
N
K
E
E
Y
M
A
F
M
N
D
F
Site 64
S552
K
R
F
L
L
E
I
S
N
P
D
T
I
S
N
Site 65
T556
L
E
I
S
N
P
D
T
I
S
N
T
P
G
F
Site 66
S558
I
S
N
P
D
T
I
S
N
T
P
G
F
D
G
Site 67
T560
N
P
D
T
I
S
N
T
P
G
F
D
G
Y
I
Site 68
Y566
N
T
P
G
F
D
G
Y
I
D
L
G
R
E
L
Site 69
S585
S
L
L
W
E
V
V
S
Q
L
D
K
G
E
N
Site 70
S593
Q
L
D
K
G
E
N
S
F
L
Q
A
T
V
A
Site 71
T613
P
R
V
L
A
D
I
T
K
S
L
T
N
P
T
Site 72
T620
T
K
S
L
T
N
P
T
P
I
Q
Q
Q
L
R
Site 73
T630
Q
Q
Q
L
R
R
F
T
E
H
N
S
S
P
N
Site 74
S634
R
R
F
T
E
H
N
S
S
P
N
V
S
G
S
Site 75
S635
R
F
T
E
H
N
S
S
P
N
V
S
G
S
L
Site 76
S639
H
N
S
S
P
N
V
S
G
S
L
S
S
G
L
Site 77
S641
S
S
P
N
V
S
G
S
L
S
S
G
L
Q
K
Site 78
S643
P
N
V
S
G
S
L
S
S
G
L
Q
K
I
F
Site 79
T654
Q
K
I
F
E
D
P
T
D
S
D
L
H
K
L
Site 80
S656
I
F
E
D
P
T
D
S
D
L
H
K
L
K
S
Site 81
S663
S
D
L
H
K
L
K
S
P
S
Q
D
N
T
D
Site 82
S665
L
H
K
L
K
S
P
S
Q
D
N
T
D
S
Y
Site 83
T669
K
S
P
S
Q
D
N
T
D
S
Y
F
R
G
K
Site 84
S671
P
S
Q
D
N
T
D
S
Y
F
R
G
K
T
L
Site 85
Y672
S
Q
D
N
T
D
S
Y
F
R
G
K
T
L
L
Site 86
T677
D
S
Y
F
R
G
K
T
L
L
L
V
Q
Q
A
Site 87
S685
L
L
L
V
Q
Q
A
S
S
Q
S
M
T
Y
S
Site 88
S686
L
L
V
Q
Q
A
S
S
Q
S
M
T
Y
S
E
Site 89
S688
V
Q
Q
A
S
S
Q
S
M
T
Y
S
E
K
D
Site 90
T690
Q
A
S
S
Q
S
M
T
Y
S
E
K
D
E
R
Site 91
S692
S
S
Q
S
M
T
Y
S
E
K
D
E
R
E
S
Site 92
S699
S
E
K
D
E
R
E
S
S
L
P
N
G
R
S
Site 93
S700
E
K
D
E
R
E
S
S
L
P
N
G
R
S
V
Site 94
S706
S
S
L
P
N
G
R
S
V
S
L
M
D
L
Q
Site 95
S708
L
P
N
G
R
S
V
S
L
M
D
L
Q
D
T
Site 96
T715
S
L
M
D
L
Q
D
T
H
A
A
Q
V
E
H
Site 97
T734
L
D
V
P
I
R
L
T
G
S
Q
L
S
I
T
Site 98
S736
V
P
I
R
L
T
G
S
Q
L
S
I
T
Q
V
Site 99
S739
R
L
T
G
S
Q
L
S
I
T
Q
V
A
S
I
Site 100
T741
T
G
S
Q
L
S
I
T
Q
V
A
S
I
K
Q
Site 101
T752
S
I
K
Q
L
R
E
T
Q
S
T
P
Q
S
A
Site 102
S754
K
Q
L
R
E
T
Q
S
T
P
Q
S
A
P
Q
Site 103
T755
Q
L
R
E
T
Q
S
T
P
Q
S
A
P
Q
V
Site 104
S758
E
T
Q
S
T
P
Q
S
A
P
Q
V
R
R
P
Site 105
S780
P
G
G
L
Q
P
L
S
F
Q
N
P
V
Y
H
Site 106
Y786
L
S
F
Q
N
P
V
Y
H
L
N
N
P
I
P
Site 107
S799
I
P
A
M
P
K
A
S
I
D
S
S
L
E
N
Site 108
S802
M
P
K
A
S
I
D
S
S
L
E
N
L
S
T
Site 109
S803
P
K
A
S
I
D
S
S
L
E
N
L
S
T
A
Site 110
S808
D
S
S
L
E
N
L
S
T
A
S
S
R
S
Q
Site 111
T809
S
S
L
E
N
L
S
T
A
S
S
R
S
Q
S
Site 112
S811
L
E
N
L
S
T
A
S
S
R
S
Q
S
N
S
Site 113
S812
E
N
L
S
T
A
S
S
R
S
Q
S
N
S
E
Site 114
S814
L
S
T
A
S
S
R
S
Q
S
N
S
E
D
F
Site 115
S816
T
A
S
S
R
S
Q
S
N
S
E
D
F
K
L
Site 116
S818
S
S
R
S
Q
S
N
S
E
D
F
K
L
S
G
Site 117
S824
N
S
E
D
F
K
L
S
G
P
S
N
S
S
M
Site 118
S830
L
S
G
P
S
N
S
S
M
E
D
F
T
K
R
Site 119
T835
N
S
S
M
E
D
F
T
K
R
S
T
Q
S
E
Site 120
T839
E
D
F
T
K
R
S
T
Q
S
E
D
F
S
R
Site 121
S841
F
T
K
R
S
T
Q
S
E
D
F
S
R
R
H
Site 122
S845
S
T
Q
S
E
D
F
S
R
R
H
T
V
P
D
Site 123
T849
E
D
F
S
R
R
H
T
V
P
D
R
H
I
P
Site 124
S864
L
A
L
P
R
Q
N
S
T
G
Q
A
Q
I
R
Site 125
T865
A
L
P
R
Q
N
S
T
G
Q
A
Q
I
R
K
Site 126
S887
A
R
A
K
A
P
P
S
L
P
H
S
A
S
L
Site 127
S891
A
P
P
S
L
P
H
S
A
S
L
R
S
T
G
Site 128
S893
P
S
L
P
H
S
A
S
L
R
S
T
G
S
M
Site 129
S896
P
H
S
A
S
L
R
S
T
G
S
M
S
V
V
Site 130
T897
H
S
A
S
L
R
S
T
G
S
M
S
V
V
S
Site 131
S916
A
E
P
V
Q
N
G
S
R
S
R
Q
Q
S
S
Site 132
S918
P
V
Q
N
G
S
R
S
R
Q
Q
S
S
S
S
Site 133
S922
G
S
R
S
R
Q
Q
S
S
S
S
R
E
S
P
Site 134
S923
S
R
S
R
Q
Q
S
S
S
S
R
E
S
P
V
Site 135
S924
R
S
R
Q
Q
S
S
S
S
R
E
S
P
V
P
Site 136
S925
S
R
Q
Q
S
S
S
S
R
E
S
P
V
P
K
Site 137
S928
Q
S
S
S
S
R
E
S
P
V
P
K
V
R
A
Site 138
T941
R
A
I
Q
R
Q
Q
T
Q
Q
V
Q
S
P
V
Site 139
S946
Q
Q
T
Q
Q
V
Q
S
P
V
D
S
A
T
M
Site 140
S950
Q
V
Q
S
P
V
D
S
A
T
M
S
P
V
E
Site 141
T952
Q
S
P
V
D
S
A
T
M
S
P
V
E
R
T
Site 142
S954
P
V
D
S
A
T
M
S
P
V
E
R
T
A
A
Site 143
Y989
E
A
K
H
A
E
K
Y
E
Q
E
I
T
K
L
Site 144
T994
E
K
Y
E
Q
E
I
T
K
L
K
E
R
L
R
Site 145
S1003
L
K
E
R
L
R
V
S
S
R
R
L
E
E
Y
Site 146
S1004
K
E
R
L
R
V
S
S
R
R
L
E
E
Y
E
Site 147
Y1010
S
S
R
R
L
E
E
Y
E
R
R
L
L
V
Q
Site 148
S1035
Y
K
A
R
L
E
D
S
E
E
R
L
R
R
Q
Site 149
S1048
R
Q
Q
E
E
K
D
S
Q
M
K
S
I
I
S
Site 150
S1052
E
K
D
S
Q
M
K
S
I
I
S
R
L
M
A
Site 151
S1091
A
Q
E
K
R
I
V
S
L
D
S
A
N
T
R
Site 152
S1094
K
R
I
V
S
L
D
S
A
N
T
R
L
M
S
Site 153
S1101
S
A
N
T
R
L
M
S
A
L
T
Q
V
K
E
Site 154
T1104
T
R
L
M
S
A
L
T
Q
V
K
E
R
Y
S
Site 155
S1111
T
Q
V
K
E
R
Y
S
M
Q
V
R
N
G
I
Site 156
S1119
M
Q
V
R
N
G
I
S
P
T
N
P
T
K
L
Site 157
T1121
V
R
N
G
I
S
P
T
N
P
T
K
L
S
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation