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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MBD1
Full Name:
Methyl-CpG-binding domain protein 1
Alias:
CXXC3; methyl-CpG binding domain protein 1; PCM1; RFT
Type:
Transcription protein, repressor
Mass (Da):
66607
Number AA:
605
UniProt ID:
Q9UIS9
International Prot ID:
IPI00438701
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0008327
GO:0003714
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0016481
GO:0006366
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
R
R
E
V
F
R
K
S
G
A
T
C
G
R
S
Site 2
T27
V
F
R
K
S
G
A
T
C
G
R
S
D
T
Y
Site 3
T33
A
T
C
G
R
S
D
T
Y
Y
Q
S
P
T
G
Site 4
Y34
T
C
G
R
S
D
T
Y
Y
Q
S
P
T
G
D
Site 5
Y35
C
G
R
S
D
T
Y
Y
Q
S
P
T
G
D
R
Site 6
S37
R
S
D
T
Y
Y
Q
S
P
T
G
D
R
I
R
Site 7
S45
P
T
G
D
R
I
R
S
K
V
E
L
T
R
Y
Site 8
Y52
S
K
V
E
L
T
R
Y
L
G
P
A
C
D
L
Site 9
Y71
F
K
Q
G
I
L
C
Y
P
A
P
K
A
H
P
Site 10
S83
A
H
P
V
A
V
A
S
K
K
R
K
K
P
S
Site 11
S90
S
K
K
R
K
K
P
S
R
P
A
K
T
R
K
Site 12
S104
K
R
Q
V
G
P
Q
S
G
E
V
R
K
E
A
Site 13
T116
K
E
A
P
R
D
E
T
K
A
D
T
D
T
A
Site 14
T120
R
D
E
T
K
A
D
T
D
T
A
P
A
S
F
Site 15
T122
E
T
K
A
D
T
D
T
A
P
A
S
F
P
A
Site 16
S126
D
T
D
T
A
P
A
S
F
P
A
P
G
C
C
Site 17
S141
E
N
C
G
I
S
F
S
G
D
G
T
Q
R
Q
Site 18
T145
I
S
F
S
G
D
G
T
Q
R
Q
R
L
K
T
Site 19
T152
T
Q
R
Q
R
L
K
T
L
C
K
D
C
R
A
Site 20
S276
R
R
K
G
G
C
D
S
K
M
A
A
R
R
R
Site 21
S295
P
L
P
P
P
P
P
S
Q
S
P
E
P
T
E
Site 22
S297
P
P
P
P
P
S
Q
S
P
E
P
T
E
P
H
Site 23
T301
P
S
Q
S
P
E
P
T
E
P
H
P
R
A
L
Site 24
S311
H
P
R
A
L
A
P
S
P
P
A
E
F
I
Y
Site 25
Y318
S
P
P
A
E
F
I
Y
Y
C
V
D
E
D
E
Site 26
Y319
P
P
A
E
F
I
Y
Y
C
V
D
E
D
E
L
Site 27
Y329
D
E
D
E
L
Q
P
Y
T
N
R
R
Q
N
R
Site 28
T330
E
D
E
L
Q
P
Y
T
N
R
R
Q
N
R
K
Site 29
S365
D
K
P
K
F
G
G
S
N
Q
K
R
Q
K
C
Site 30
S388
A
M
K
R
L
L
P
S
V
W
S
E
S
E
D
Site 31
S391
R
L
L
P
S
V
W
S
E
S
E
D
G
A
G
Site 32
S393
L
P
S
V
W
S
E
S
E
D
G
A
G
S
P
Site 33
S399
E
S
E
D
G
A
G
S
P
P
P
Y
R
R
R
Site 34
Y403
G
A
G
S
P
P
P
Y
R
R
R
K
R
P
S
Site 35
S410
Y
R
R
R
K
R
P
S
S
A
R
R
H
H
L
Site 36
S411
R
R
R
K
R
P
S
S
A
R
R
H
H
L
G
Site 37
T420
R
R
H
H
L
G
P
T
L
K
P
T
L
A
T
Site 38
T424
L
G
P
T
L
K
P
T
L
A
T
R
T
A
Q
Site 39
T435
R
T
A
Q
P
D
H
T
Q
A
P
T
K
Q
E
Site 40
S465
F
L
R
E
G
A
S
S
P
V
Q
V
P
G
P
Site 41
T505
V
K
Q
E
K
A
D
T
Q
D
E
W
T
P
G
Site 42
T510
A
D
T
Q
D
E
W
T
P
G
T
A
V
L
T
Site 43
T513
Q
D
E
W
T
P
G
T
A
V
L
T
S
P
V
Site 44
S536
A
V
D
P
G
L
P
S
V
K
Q
E
P
P
D
Site 45
S555
K
E
E
N
K
D
D
S
A
S
K
L
A
P
E
Site 46
S557
E
N
K
D
D
S
A
S
K
L
A
P
E
E
E
Site 47
T570
E
E
A
G
G
A
G
T
P
V
I
T
E
I
F
Site 48
T574
G
A
G
T
P
V
I
T
E
I
F
S
L
G
G
Site 49
T582
E
I
F
S
L
G
G
T
R
F
R
D
T
A
V
Site 50
T587
G
G
T
R
F
R
D
T
A
V
W
L
P
R
S
Site 51
S594
T
A
V
W
L
P
R
S
K
D
L
K
K
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation