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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DAPK2
Full Name:
Death-associated protein kinase 2
Alias:
DAP-kinase related protein 1; DRP-1; EC 2.7.11.1
Type:
Protein-serine kinase, CAMK group, DAPK family
Mass (Da):
42898
Number AA:
370
UniProt ID:
Q9UIK4
International Prot ID:
IPI00033388
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005516
GO:0004683
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0006917
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
MYL9 (12-23) KinSub - Myosin light chain 9 (A12-S23, human) peptide; PHKG protein kinase substrate peptide - Powder PE-01ADE95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADE95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
F
Q
A
S
M
R
S
P
N
M
E
P
F
K
Site 2
Y23
Q
Q
K
V
E
D
F
Y
D
I
G
E
E
L
G
Site 3
S44
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
Site 4
Y49
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
Site 5
S59
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
Site 6
S62
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
Site 7
S67
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
Site 8
S76
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
Site 9
S120
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
Site 10
S122
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
Site 11
T127
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
Site 12
S128
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
Site 13
Y139
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
Site 14
T190
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
Site 15
T231
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
Site 16
T235
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
Site 17
S252
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
Site 18
T275
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
Site 19
T286
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
Site 20
S299
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
Site 21
Y310
L
E
N
F
R
K
Q
Y
V
R
R
R
W
K
L
Site 22
S318
V
R
R
R
W
K
L
S
F
S
I
V
S
L
C
Site 23
S320
R
R
W
K
L
S
F
S
I
V
S
L
C
N
H
Site 24
S331
L
C
N
H
L
T
R
S
L
M
K
K
V
H
L
Site 25
S349
E
D
L
R
N
C
E
S
D
T
E
E
D
I
A
Site 26
T351
L
R
N
C
E
S
D
T
E
E
D
I
A
R
R
Site 27
S367
A
L
H
P
R
R
R
S
S
T
S
_
_
_
_
Site 28
S368
L
H
P
R
R
R
S
S
T
S
_
_
_
_
_
Site 29
T369
H
P
R
R
R
S
S
T
S
_
_
_
_
_
_
Site 30
S370
P
R
R
R
S
S
T
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation