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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LIMA1
Full Name:
ISOFORM BETA OF LIM DOMAIN AND ACTIN-BINDING PROTEIN 1.
Alias:
Epithelial protein lost in neoplasm
Type:
Cytoskeletal protein
Mass (Da):
85226
Number AA:
759
UniProt ID:
Q9UHB6
International Prot ID:
IPI00008918
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005925
GO:0001725
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0003785
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0051017
GO:0030835
GO:0031529
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
E
S
S
P
F
N
R
R
Q
W
Site 2
T12
P
F
N
R
R
Q
W
T
S
L
S
L
R
V
T
Site 3
S13
F
N
R
R
Q
W
T
S
L
S
L
R
V
T
A
Site 4
S15
R
R
Q
W
T
S
L
S
L
R
V
T
A
K
E
Site 5
S24
R
V
T
A
K
E
L
S
L
V
N
K
N
K
S
Site 6
Y41
I
V
E
I
F
S
K
Y
Q
K
A
A
E
E
T
Site 7
S55
T
N
M
E
K
K
R
S
N
T
E
N
L
S
Q
Site 8
T57
M
E
K
K
R
S
N
T
E
N
L
S
Q
H
F
Site 9
S61
R
S
N
T
E
N
L
S
Q
H
F
R
K
G
T
Site 10
T68
S
Q
H
F
R
K
G
T
L
T
V
L
K
K
K
Site 11
T70
H
F
R
K
G
T
L
T
V
L
K
K
K
W
E
Site 12
S85
N
P
G
L
G
A
E
S
H
T
D
S
L
R
N
Site 13
S89
G
A
E
S
H
T
D
S
L
R
N
S
S
T
E
Site 14
S93
H
T
D
S
L
R
N
S
S
T
E
I
R
H
R
Site 15
S94
T
D
S
L
R
N
S
S
T
E
I
R
H
R
A
Site 16
T95
D
S
L
R
N
S
S
T
E
I
R
H
R
A
D
Site 17
T109
D
H
P
P
A
E
V
T
S
H
A
A
S
G
A
Site 18
S110
H
P
P
A
E
V
T
S
H
A
A
S
G
A
K
Site 19
S114
E
V
T
S
H
A
A
S
G
A
K
A
D
Q
E
Site 20
S128
E
E
Q
I
H
P
R
S
R
L
R
S
P
P
E
Site 21
S132
H
P
R
S
R
L
R
S
P
P
E
A
L
V
Q
Site 22
Y142
E
A
L
V
Q
G
R
Y
P
H
I
K
D
G
E
Site 23
S155
G
E
D
L
K
D
H
S
T
E
S
K
K
M
E
Site 24
T156
E
D
L
K
D
H
S
T
E
S
K
K
M
E
N
Site 25
S158
L
K
D
H
S
T
E
S
K
K
M
E
N
C
L
Site 26
S175
S
R
H
E
V
E
K
S
E
I
S
E
N
T
D
Site 27
Y190
A
S
G
K
I
E
K
Y
N
V
P
L
N
R
L
Site 28
T209
E
K
G
E
P
T
Q
T
K
I
L
R
A
Q
S
Site 29
S216
T
K
I
L
R
A
Q
S
R
S
A
S
G
R
K
Site 30
S218
I
L
R
A
Q
S
R
S
A
S
G
R
K
I
S
Site 31
S220
R
A
Q
S
R
S
A
S
G
R
K
I
S
E
N
Site 32
S225
S
A
S
G
R
K
I
S
E
N
S
Y
S
L
D
Site 33
S228
G
R
K
I
S
E
N
S
Y
S
L
D
D
L
E
Site 34
Y229
R
K
I
S
E
N
S
Y
S
L
D
D
L
E
I
Site 35
S230
K
I
S
E
N
S
Y
S
L
D
D
L
E
I
G
Site 36
S242
E
I
G
P
G
Q
L
S
S
S
T
F
D
S
E
Site 37
S243
I
G
P
G
Q
L
S
S
S
T
F
D
S
E
K
Site 38
S244
G
P
G
Q
L
S
S
S
T
F
D
S
E
K
N
Site 39
T245
P
G
Q
L
S
S
S
T
F
D
S
E
K
N
E
Site 40
S248
L
S
S
S
T
F
D
S
E
K
N
E
S
R
R
Site 41
S253
F
D
S
E
K
N
E
S
R
R
N
L
E
L
P
Site 42
S263
N
L
E
L
P
R
L
S
E
T
S
I
K
D
R
Site 43
S266
L
P
R
L
S
E
T
S
I
K
D
R
M
A
K
Site 44
Y274
I
K
D
R
M
A
K
Y
Q
A
A
V
S
K
Q
Site 45
S279
A
K
Y
Q
A
A
V
S
K
Q
S
S
S
T
N
Site 46
S283
A
A
V
S
K
Q
S
S
S
T
N
Y
T
N
E
Site 47
S284
A
V
S
K
Q
S
S
S
T
N
Y
T
N
E
L
Site 48
Y287
K
Q
S
S
S
T
N
Y
T
N
E
L
K
A
S
Site 49
T288
Q
S
S
S
T
N
Y
T
N
E
L
K
A
S
G
Site 50
S294
Y
T
N
E
L
K
A
S
G
G
E
I
K
I
H
Site 51
T318
P
G
P
E
V
C
I
T
H
Q
E
G
E
K
I
Site 52
S331
K
I
S
A
N
E
N
S
L
A
V
R
S
T
P
Site 53
S336
E
N
S
L
A
V
R
S
T
P
A
E
D
D
S
Site 54
T337
N
S
L
A
V
R
S
T
P
A
E
D
D
S
R
Site 55
S343
S
T
P
A
E
D
D
S
R
D
S
Q
V
K
S
Site 56
S346
A
E
D
D
S
R
D
S
Q
V
K
S
E
V
Q
Site 57
S350
S
R
D
S
Q
V
K
S
E
V
Q
Q
P
V
H
Site 58
S362
P
V
H
P
K
P
L
S
P
D
S
R
A
S
S
Site 59
S365
P
K
P
L
S
P
D
S
R
A
S
S
L
S
E
Site 60
S368
L
S
P
D
S
R
A
S
S
L
S
E
S
S
P
Site 61
S369
S
P
D
S
R
A
S
S
L
S
E
S
S
P
P
Site 62
S371
D
S
R
A
S
S
L
S
E
S
S
P
P
K
A
Site 63
S373
R
A
S
S
L
S
E
S
S
P
P
K
A
M
K
Site 64
S374
A
S
S
L
S
E
S
S
P
P
K
A
M
K
K
Site 65
T389
F
Q
A
P
A
R
E
T
C
V
E
C
Q
K
T
Site 66
Y398
V
E
C
Q
K
T
V
Y
P
M
E
R
L
L
A
Site 67
S425
S
Y
C
N
N
K
L
S
L
G
T
Y
A
S
L
Site 68
T428
N
N
K
L
S
L
G
T
Y
A
S
L
H
G
R
Site 69
Y429
N
K
L
S
L
G
T
Y
A
S
L
H
G
R
I
Site 70
S431
L
S
L
G
T
Y
A
S
L
H
G
R
I
Y
C
Site 71
Y437
A
S
L
H
G
R
I
Y
C
K
P
H
F
N
Q
Site 72
Y452
L
F
K
S
K
G
N
Y
D
E
G
F
G
H
R
Site 73
T487
Q
L
A
N
A
R
E
T
P
H
S
P
G
V
E
Site 74
S490
N
A
R
E
T
P
H
S
P
G
V
E
D
A
P
Site 75
S514
S
M
E
A
K
A
S
S
Q
Q
E
K
E
D
K
Site 76
T536
R
I
A
W
P
P
P
T
E
L
G
S
S
G
S
Site 77
S540
P
P
P
T
E
L
G
S
S
G
S
A
L
E
E
Site 78
S541
P
P
T
E
L
G
S
S
G
S
A
L
E
E
G
Site 79
S543
T
E
L
G
S
S
G
S
A
L
E
E
G
I
K
Site 80
S552
L
E
E
G
I
K
M
S
K
P
K
W
P
P
E
Site 81
S563
W
P
P
E
D
E
I
S
K
P
E
V
P
E
D
Site 82
S581
D
L
K
K
L
R
R
S
S
S
L
K
E
R
S
Site 83
S582
L
K
K
L
R
R
S
S
S
L
K
E
R
S
R
Site 84
S583
K
K
L
R
R
S
S
S
L
K
E
R
S
R
P
Site 85
S588
S
S
S
L
K
E
R
S
R
P
F
T
V
A
A
Site 86
T592
K
E
R
S
R
P
F
T
V
A
A
S
F
Q
S
Site 87
S596
R
P
F
T
V
A
A
S
F
Q
S
T
S
V
K
Site 88
S599
T
V
A
A
S
F
Q
S
T
S
V
K
S
P
K
Site 89
T600
V
A
A
S
F
Q
S
T
S
V
K
S
P
K
T
Site 90
S601
A
A
S
F
Q
S
T
S
V
K
S
P
K
T
V
Site 91
S604
F
Q
S
T
S
V
K
S
P
K
T
V
S
P
P
Site 92
T607
T
S
V
K
S
P
K
T
V
S
P
P
I
R
K
Site 93
S609
V
K
S
P
K
T
V
S
P
P
I
R
K
G
W
Site 94
S617
P
P
I
R
K
G
W
S
M
S
E
Q
S
E
E
Site 95
S619
I
R
K
G
W
S
M
S
E
Q
S
E
E
S
V
Site 96
S622
G
W
S
M
S
E
Q
S
E
E
S
V
G
G
R
Site 97
S642
Q
V
E
N
A
K
A
S
K
K
N
G
N
V
G
Site 98
T662
N
K
E
S
K
G
E
T
G
K
R
S
K
E
G
Site 99
S666
K
G
E
T
G
K
R
S
K
E
G
H
S
L
E
Site 100
S671
K
R
S
K
E
G
H
S
L
E
M
E
N
E
N
Site 101
S686
L
V
E
N
G
A
D
S
D
E
D
D
N
S
F
Site 102
S692
D
S
D
E
D
D
N
S
F
L
K
Q
Q
S
P
Site 103
S698
N
S
F
L
K
Q
Q
S
P
Q
E
P
K
S
L
Site 104
S704
Q
S
P
Q
E
P
K
S
L
N
W
S
S
F
V
Site 105
S708
E
P
K
S
L
N
W
S
S
F
V
D
N
T
F
Site 106
S709
P
K
S
L
N
W
S
S
F
V
D
N
T
F
A
Site 107
T714
W
S
S
F
V
D
N
T
F
A
E
E
F
T
T
Site 108
T721
T
F
A
E
E
F
T
T
Q
N
Q
K
S
Q
D
Site 109
S726
F
T
T
Q
N
Q
K
S
Q
D
V
E
L
W
E
Site 110
S741
G
E
V
V
K
E
L
S
V
E
E
Q
I
K
R
Site 111
Y751
E
Q
I
K
R
N
R
Y
Y
D
E
D
E
D
E
Site 112
Y752
Q
I
K
R
N
R
Y
Y
D
E
D
E
D
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation