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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Daxx
Full Name:
Death domain-associated protein 6
Alias:
BING2; DAP6; Death-domain associated protein; EAP1; ETS1 associated protein 1; Fas DEATH domain- associated protein
Type:
Nuclear receptor co-regulator; Apoptosis; Transcription, coactivator/corepressor
Mass (Da):
81373
Number AA:
740
UniProt ID:
Q9UER7
International Prot ID:
IPI00170867
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0050681
GO:0031072
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0007257
GO:0030521
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
H
P
L
P
N
A
A
S
P
G
A
E
A
P
S
Site 2
S40
S
P
G
A
E
A
P
S
S
S
E
P
H
G
A
Site 3
S41
P
G
A
E
A
P
S
S
S
E
P
H
G
A
R
Site 4
S42
G
A
E
A
P
S
S
S
E
P
H
G
A
R
G
Site 5
S50
E
P
H
G
A
R
G
S
S
S
S
G
G
K
K
Site 6
S51
P
H
G
A
R
G
S
S
S
S
G
G
K
K
C
Site 7
S52
H
G
A
R
G
S
S
S
S
G
G
K
K
C
Y
Site 8
S53
G
A
R
G
S
S
S
S
G
G
K
K
C
Y
K
Site 9
Y89
P
E
V
V
P
F
L
Y
N
R
Q
Q
R
A
H
Site 10
S97
N
R
Q
Q
R
A
H
S
L
F
L
A
S
A
E
Site 11
S114
N
I
L
S
R
V
L
S
R
A
R
S
R
P
A
Site 12
S118
R
V
L
S
R
A
R
S
R
P
A
K
L
Y
V
Site 13
Y124
R
S
R
P
A
K
L
Y
V
Y
I
N
E
L
C
Site 14
Y126
R
P
A
K
L
Y
V
Y
I
N
E
L
C
T
V
Site 15
T150
L
N
L
A
P
A
A
T
T
S
N
E
P
S
G
Site 16
S152
L
A
P
A
A
T
T
S
N
E
P
S
G
N
N
Site 17
S156
A
T
T
S
N
E
P
S
G
N
N
P
P
T
H
Site 18
T162
P
S
G
N
N
P
P
T
H
L
S
L
D
P
T
Site 19
S165
N
N
P
P
T
H
L
S
L
D
P
T
N
A
E
Site 20
T169
T
H
L
S
L
D
P
T
N
A
E
N
T
A
S
Site 21
T174
D
P
T
N
A
E
N
T
A
S
Q
S
P
R
T
Site 22
S176
T
N
A
E
N
T
A
S
Q
S
P
R
T
R
G
Site 23
S178
A
E
N
T
A
S
Q
S
P
R
T
R
G
S
R
Site 24
S184
Q
S
P
R
T
R
G
S
R
R
Q
I
Q
R
L
Site 25
S213
Q
E
K
E
L
D
L
S
E
L
D
D
P
D
S
Site 26
S220
S
E
L
D
D
P
D
S
A
Y
L
Q
E
A
R
Site 27
Y222
L
D
D
P
D
S
A
Y
L
Q
E
A
R
L
K
Site 28
S246
L
C
E
L
K
D
C
S
S
L
T
G
R
V
I
Site 29
S247
C
E
L
K
D
C
S
S
L
T
G
R
V
I
E
Site 30
T249
L
K
D
C
S
S
L
T
G
R
V
I
E
Q
R
Site 31
Y259
V
I
E
Q
R
I
P
Y
R
G
T
R
Y
P
E
Site 32
T262
Q
R
I
P
Y
R
G
T
R
Y
P
E
V
N
R
Site 33
Y264
I
P
Y
R
G
T
R
Y
P
E
V
N
R
R
I
Site 34
T282
I
N
K
P
G
P
D
T
F
P
D
Y
G
D
V
Site 35
Y286
G
P
D
T
F
P
D
Y
G
D
V
L
R
A
V
Site 36
S301
E
K
A
A
A
R
H
S
L
G
L
P
R
Q
Q
Site 37
Y334
R
R
H
L
D
L
I
Y
N
F
G
C
H
L
T
Site 38
Y344
G
C
H
L
T
D
D
Y
R
P
G
V
D
P
A
Site 39
S353
P
G
V
D
P
A
L
S
D
P
V
L
A
R
R
Site 40
S366
R
R
L
R
E
N
R
S
L
A
M
S
R
L
D
Site 41
S370
E
N
R
S
L
A
M
S
R
L
D
E
V
I
S
Site 42
S377
S
R
L
D
E
V
I
S
K
Y
A
M
L
Q
D
Site 43
Y379
L
D
E
V
I
S
K
Y
A
M
L
Q
D
K
S
Site 44
S386
Y
A
M
L
Q
D
K
S
E
E
G
E
R
K
K
Site 45
S402
R
A
R
L
Q
G
T
S
S
H
S
A
D
T
P
Site 46
S403
A
R
L
Q
G
T
S
S
H
S
A
D
T
P
E
Site 47
T408
T
S
S
H
S
A
D
T
P
E
A
S
L
D
S
Site 48
S412
S
A
D
T
P
E
A
S
L
D
S
G
E
G
P
Site 49
S415
T
P
E
A
S
L
D
S
G
E
G
P
S
G
M
Site 50
S420
L
D
S
G
E
G
P
S
G
M
A
S
Q
G
C
Site 51
S424
E
G
P
S
G
M
A
S
Q
G
C
P
S
A
S
Site 52
S431
S
Q
G
C
P
S
A
S
R
A
E
T
D
D
E
Site 53
T435
P
S
A
S
R
A
E
T
D
D
E
D
D
E
E
Site 54
S443
D
D
E
D
D
E
E
S
D
E
E
E
E
E
E
Site 55
T459
E
E
E
E
E
E
A
T
D
S
E
E
E
E
D
Site 56
S461
E
E
E
E
A
T
D
S
E
E
E
E
D
L
E
Site 57
S495
A
G
K
D
G
D
K
S
P
M
S
S
L
Q
I
Site 58
S498
D
G
D
K
S
P
M
S
S
L
Q
I
S
N
E
Site 59
S499
G
D
K
S
P
M
S
S
L
Q
I
S
N
E
K
Site 60
S503
P
M
S
S
L
Q
I
S
N
E
K
N
L
E
P
Site 61
S515
L
E
P
G
K
Q
I
S
R
S
S
G
E
Q
Q
Site 62
S517
P
G
K
Q
I
S
R
S
S
G
E
Q
Q
N
K
Site 63
S518
G
K
Q
I
S
R
S
S
G
E
Q
Q
N
K
G
Site 64
S529
Q
N
K
G
R
I
V
S
P
S
L
L
S
E
E
Site 65
S531
K
G
R
I
V
S
P
S
L
L
S
E
E
P
L
Site 66
S542
E
E
P
L
A
P
S
S
I
D
A
E
S
N
G
Site 67
S547
P
S
S
I
D
A
E
S
N
G
E
Q
P
E
E
Site 68
T556
G
E
Q
P
E
E
L
T
L
E
E
E
S
P
V
Site 69
S561
E
L
T
L
E
E
E
S
P
V
S
Q
L
F
E
Site 70
S564
L
E
E
E
S
P
V
S
Q
L
F
E
L
E
I
Site 71
T578
I
E
A
L
P
L
D
T
P
S
S
V
E
T
D
Site 72
S581
L
P
L
D
T
P
S
S
V
E
T
D
I
S
S
Site 73
T584
D
T
P
S
S
V
E
T
D
I
S
S
S
R
K
Site 74
S587
S
S
V
E
T
D
I
S
S
S
R
K
Q
S
E
Site 75
S588
S
V
E
T
D
I
S
S
S
R
K
Q
S
E
E
Site 76
S589
V
E
T
D
I
S
S
S
R
K
Q
S
E
E
P
Site 77
S593
I
S
S
S
R
K
Q
S
E
E
P
F
T
T
V
Site 78
T598
K
Q
S
E
E
P
F
T
T
V
L
E
N
G
A
Site 79
T599
Q
S
E
E
P
F
T
T
V
L
E
N
G
A
G
Site 80
S609
E
N
G
A
G
M
V
S
S
T
S
F
N
G
G
Site 81
S618
T
S
F
N
G
G
V
S
P
H
N
W
G
D
S
Site 82
S625
S
P
H
N
W
G
D
S
G
P
P
C
K
K
S
Site 83
S632
S
G
P
P
C
K
K
S
R
K
E
K
K
Q
T
Site 84
T639
S
R
K
E
K
K
Q
T
G
S
G
P
L
G
N
Site 85
S647
G
S
G
P
L
G
N
S
Y
V
E
R
Q
R
S
Site 86
Y648
S
G
P
L
G
N
S
Y
V
E
R
Q
R
S
V
Site 87
S654
S
Y
V
E
R
Q
R
S
V
H
E
K
N
G
K
Site 88
T665
K
N
G
K
K
I
C
T
L
P
S
P
P
S
P
Site 89
S668
K
K
I
C
T
L
P
S
P
P
S
P
L
A
S
Site 90
S671
C
T
L
P
S
P
P
S
P
L
A
S
L
A
P
Site 91
S675
S
P
P
S
P
L
A
S
L
A
P
V
A
D
S
Site 92
S682
S
L
A
P
V
A
D
S
S
T
R
V
D
S
P
Site 93
S683
L
A
P
V
A
D
S
S
T
R
V
D
S
P
S
Site 94
T684
A
P
V
A
D
S
S
T
R
V
D
S
P
S
H
Site 95
S688
D
S
S
T
R
V
D
S
P
S
H
G
L
V
T
Site 96
S690
S
T
R
V
D
S
P
S
H
G
L
V
T
S
S
Site 97
T695
S
P
S
H
G
L
V
T
S
S
L
C
I
P
S
Site 98
S697
S
H
G
L
V
T
S
S
L
C
I
P
S
P
A
Site 99
S702
T
S
S
L
C
I
P
S
P
A
R
L
S
Q
T
Site 100
S707
I
P
S
P
A
R
L
S
Q
T
P
H
S
Q
P
Site 101
T709
S
P
A
R
L
S
Q
T
P
H
S
Q
P
P
R
Site 102
S712
R
L
S
Q
T
P
H
S
Q
P
P
R
P
G
T
Site 103
T719
S
Q
P
P
R
P
G
T
C
K
T
S
V
A
T
Site 104
T722
P
R
P
G
T
C
K
T
S
V
A
T
Q
C
D
Site 105
S723
R
P
G
T
C
K
T
S
V
A
T
Q
C
D
P
Site 106
S737
P
E
E
I
I
V
L
S
D
S
D
_
_
_
_
Site 107
S739
E
I
I
V
L
S
D
S
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation