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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPARGC1A
Full Name:
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Alias:
LEM6; Ligand effect modulator 6; Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC1; PGC1A; PPAR gamma coactivator; PPAR gamma coactivator-1; PPARGC1; PRGC1
Type:
Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
91027
Number AA:
798
UniProt ID:
Q9UBK2
International Prot ID:
IPI00033138
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005665
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003723
GO:0016455
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0030521
GO:0050873
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
Q
D
S
E
S
V
W
S
D
I
E
C
A
A
L
Site 2
S39
D
L
P
E
L
D
L
S
E
L
D
V
N
D
L
Site 3
S50
V
N
D
L
D
T
D
S
F
L
G
G
L
K
W
Site 4
S59
L
G
G
L
K
W
C
S
D
Q
S
E
I
I
S
Site 5
S66
S
D
Q
S
E
I
I
S
N
Q
Y
N
N
E
P
Site 6
S98
V
L
T
E
T
L
D
S
L
P
V
D
E
D
G
Site 7
S108
V
D
E
D
G
L
P
S
F
D
A
L
T
D
G
Site 8
T113
L
P
S
F
D
A
L
T
D
G
D
V
T
T
D
Site 9
T119
L
T
D
G
D
V
T
T
D
N
E
A
S
P
S
Site 10
S124
V
T
T
D
N
E
A
S
P
S
S
M
P
D
G
Site 11
S126
T
D
N
E
A
S
P
S
S
M
P
D
G
T
P
Site 12
S127
D
N
E
A
S
P
S
S
M
P
D
G
T
P
P
Site 13
T132
P
S
S
M
P
D
G
T
P
P
P
Q
E
A
E
Site 14
S142
P
Q
E
A
E
E
P
S
L
L
K
K
L
L
L
Site 15
S157
A
P
A
N
T
Q
L
S
Y
N
E
C
S
G
L
Site 16
Y158
P
A
N
T
Q
L
S
Y
N
E
C
S
G
L
S
Site 17
T178
N
H
N
H
R
I
R
T
N
P
A
I
V
K
T
Site 18
T185
T
N
P
A
I
V
K
T
E
N
S
W
S
N
K
Site 19
S188
A
I
V
K
T
E
N
S
W
S
N
K
A
K
S
Site 20
S195
S
W
S
N
K
A
K
S
I
C
Q
Q
Q
K
P
Site 21
S208
K
P
Q
R
R
P
C
S
E
L
L
K
Y
L
T
Site 22
Y213
P
C
S
E
L
L
K
Y
L
T
T
N
D
D
P
Site 23
T215
S
E
L
L
K
Y
L
T
T
N
D
D
P
P
H
Site 24
T216
E
L
L
K
Y
L
T
T
N
D
D
P
P
H
T
Site 25
T226
D
P
P
H
T
K
P
T
E
N
R
N
S
S
R
Site 26
S231
K
P
T
E
N
R
N
S
S
R
D
K
C
T
S
Site 27
S232
P
T
E
N
R
N
S
S
R
D
K
C
T
S
K
Site 28
T237
N
S
S
R
D
K
C
T
S
K
K
K
S
H
T
Site 29
S238
S
S
R
D
K
C
T
S
K
K
K
S
H
T
Q
Site 30
S242
K
C
T
S
K
K
K
S
H
T
Q
S
Q
S
Q
Site 31
T244
T
S
K
K
K
S
H
T
Q
S
Q
S
Q
H
L
Site 32
S246
K
K
K
S
H
T
Q
S
Q
S
Q
H
L
Q
A
Site 33
S248
K
S
H
T
Q
S
Q
S
Q
H
L
Q
A
K
P
Site 34
T257
H
L
Q
A
K
P
T
T
L
S
L
P
L
T
P
Site 35
S259
Q
A
K
P
T
T
L
S
L
P
L
T
P
E
S
Site 36
T263
T
T
L
S
L
P
L
T
P
E
S
P
N
D
P
Site 37
S266
S
L
P
L
T
P
E
S
P
N
D
P
K
G
S
Site 38
S273
S
P
N
D
P
K
G
S
P
F
E
N
K
T
I
Site 39
T279
G
S
P
F
E
N
K
T
I
E
R
T
L
S
V
Site 40
T283
E
N
K
T
I
E
R
T
L
S
V
E
L
S
G
Site 41
S285
K
T
I
E
R
T
L
S
V
E
L
S
G
T
A
Site 42
T295
L
S
G
T
A
G
L
T
P
P
T
T
P
P
H
Site 43
T298
T
A
G
L
T
P
P
T
T
P
P
H
K
A
N
Site 44
T299
A
G
L
T
P
P
T
T
P
P
H
K
A
N
Q
Site 45
S313
Q
D
N
P
F
R
A
S
P
K
L
K
S
S
C
Site 46
S318
R
A
S
P
K
L
K
S
S
C
K
T
V
V
P
Site 47
T322
K
L
K
S
S
C
K
T
V
V
P
P
P
S
K
Site 48
S328
K
T
V
V
P
P
P
S
K
K
P
R
Y
S
E
Site 49
Y333
P
P
S
K
K
P
R
Y
S
E
S
S
G
T
Q
Site 50
S334
P
S
K
K
P
R
Y
S
E
S
S
G
T
Q
G
Site 51
S337
K
P
R
Y
S
E
S
S
G
T
Q
G
N
N
S
Site 52
T339
R
Y
S
E
S
S
G
T
Q
G
N
N
S
T
K
Site 53
S344
S
G
T
Q
G
N
N
S
T
K
K
G
P
E
Q
Site 54
Y355
G
P
E
Q
S
E
L
Y
A
Q
L
S
K
S
S
Site 55
S359
S
E
L
Y
A
Q
L
S
K
S
S
V
L
T
G
Site 56
S361
L
Y
A
Q
L
S
K
S
S
V
L
T
G
G
H
Site 57
S362
Y
A
Q
L
S
K
S
S
V
L
T
G
G
H
E
Site 58
T365
L
S
K
S
S
V
L
T
G
G
H
E
E
R
K
Site 59
T373
G
G
H
E
E
R
K
T
K
R
P
S
L
R
L
Site 60
S377
E
R
K
T
K
R
P
S
L
R
L
F
G
D
H
Site 61
Y386
R
L
F
G
D
H
D
Y
C
Q
S
I
N
S
K
Site 62
S401
T
E
I
L
I
N
I
S
Q
E
L
Q
D
S
R
Site 63
S407
I
S
Q
E
L
Q
D
S
R
Q
L
E
N
K
D
Site 64
S416
Q
L
E
N
K
D
V
S
S
D
W
Q
G
Q
I
Site 65
S417
L
E
N
K
D
V
S
S
D
W
Q
G
Q
I
C
Site 66
T427
Q
G
Q
I
C
S
S
T
D
S
D
Q
C
Y
L
Site 67
S429
Q
I
C
S
S
T
D
S
D
Q
C
Y
L
R
E
Site 68
Y433
S
T
D
S
D
Q
C
Y
L
R
E
T
L
E
A
Site 69
T437
D
Q
C
Y
L
R
E
T
L
E
A
S
K
Q
V
Site 70
S441
L
R
E
T
L
E
A
S
K
Q
V
S
P
C
S
Site 71
S445
L
E
A
S
K
Q
V
S
P
C
S
T
R
K
Q
Site 72
S448
S
K
Q
V
S
P
C
S
T
R
K
Q
L
Q
D
Site 73
S470
N
K
H
F
G
H
P
S
Q
A
V
F
D
D
E
Site 74
T481
F
D
D
E
A
D
K
T
G
E
L
R
D
S
D
Site 75
S487
K
T
G
E
L
R
D
S
D
F
S
N
E
Q
F
Site 76
S490
E
L
R
D
S
D
F
S
N
E
Q
F
S
K
L
Site 77
S514
M
D
G
L
F
D
D
S
E
D
E
S
D
K
L
Site 78
S518
F
D
D
S
E
D
E
S
D
K
L
S
Y
P
W
Site 79
S522
E
D
E
S
D
K
L
S
Y
P
W
D
G
T
Q
Site 80
Y523
D
E
S
D
K
L
S
Y
P
W
D
G
T
Q
S
Site 81
T528
L
S
Y
P
W
D
G
T
Q
S
Y
S
L
F
N
Site 82
S532
W
D
G
T
Q
S
Y
S
L
F
N
V
S
P
S
Site 83
S537
S
Y
S
L
F
N
V
S
P
S
C
S
S
F
N
Site 84
S539
S
L
F
N
V
S
P
S
C
S
S
F
N
S
P
Site 85
S541
F
N
V
S
P
S
C
S
S
F
N
S
P
C
R
Site 86
S542
N
V
S
P
S
C
S
S
F
N
S
P
C
R
D
Site 87
S545
P
S
C
S
S
F
N
S
P
C
R
D
S
V
S
Site 88
S550
F
N
S
P
C
R
D
S
V
S
P
P
K
S
L
Site 89
S552
S
P
C
R
D
S
V
S
P
P
K
S
L
F
S
Site 90
S556
D
S
V
S
P
P
K
S
L
F
S
Q
R
P
Q
Site 91
S559
S
P
P
K
S
L
F
S
Q
R
P
Q
R
M
R
Site 92
S567
Q
R
P
Q
R
M
R
S
R
S
R
S
F
S
R
Site 93
S569
P
Q
R
M
R
S
R
S
R
S
F
S
R
H
R
Site 94
S571
R
M
R
S
R
S
R
S
F
S
R
H
R
S
C
Site 95
S573
R
S
R
S
R
S
F
S
R
H
R
S
C
S
R
Site 96
S577
R
S
F
S
R
H
R
S
C
S
R
S
P
Y
S
Site 97
S579
F
S
R
H
R
S
C
S
R
S
P
Y
S
R
S
Site 98
S581
R
H
R
S
C
S
R
S
P
Y
S
R
S
R
S
Site 99
Y583
R
S
C
S
R
S
P
Y
S
R
S
R
S
R
S
Site 100
S584
S
C
S
R
S
P
Y
S
R
S
R
S
R
S
P
Site 101
S586
S
R
S
P
Y
S
R
S
R
S
R
S
P
G
S
Site 102
S588
S
P
Y
S
R
S
R
S
R
S
P
G
S
R
S
Site 103
S590
Y
S
R
S
R
S
R
S
P
G
S
R
S
S
S
Site 104
S593
S
R
S
R
S
P
G
S
R
S
S
S
R
S
C
Site 105
S595
S
R
S
P
G
S
R
S
S
S
R
S
C
Y
Y
Site 106
S596
R
S
P
G
S
R
S
S
S
R
S
C
Y
Y
Y
Site 107
S597
S
P
G
S
R
S
S
S
R
S
C
Y
Y
Y
E
Site 108
S599
G
S
R
S
S
S
R
S
C
Y
Y
Y
E
S
S
Site 109
Y601
R
S
S
S
R
S
C
Y
Y
Y
E
S
S
H
Y
Site 110
Y602
S
S
S
R
S
C
Y
Y
Y
E
S
S
H
Y
R
Site 111
Y603
S
S
R
S
C
Y
Y
Y
E
S
S
H
Y
R
H
Site 112
Y608
Y
Y
Y
E
S
S
H
Y
R
H
R
T
H
R
N
Site 113
T612
S
S
H
Y
R
H
R
T
H
R
N
S
P
L
Y
Site 114
S616
R
H
R
T
H
R
N
S
P
L
Y
V
R
S
R
Site 115
Y619
T
H
R
N
S
P
L
Y
V
R
S
R
S
R
S
Site 116
S622
N
S
P
L
Y
V
R
S
R
S
R
S
P
Y
S
Site 117
S624
P
L
Y
V
R
S
R
S
R
S
P
Y
S
R
R
Site 118
S626
Y
V
R
S
R
S
R
S
P
Y
S
R
R
P
R
Site 119
Y628
R
S
R
S
R
S
P
Y
S
R
R
P
R
Y
D
Site 120
S629
S
R
S
R
S
P
Y
S
R
R
P
R
Y
D
S
Site 121
Y634
P
Y
S
R
R
P
R
Y
D
S
Y
E
E
Y
Q
Site 122
S636
S
R
R
P
R
Y
D
S
Y
E
E
Y
Q
H
E
Site 123
Y637
R
R
P
R
Y
D
S
Y
E
E
Y
Q
H
E
R
Site 124
Y640
R
Y
D
S
Y
E
E
Y
Q
H
E
R
L
K
R
Site 125
Y650
E
R
L
K
R
E
E
Y
R
R
E
Y
E
K
R
Site 126
Y654
R
E
E
Y
R
R
E
Y
E
K
R
E
S
E
R
Site 127
S659
R
E
Y
E
K
R
E
S
E
R
A
K
Q
R
E
Site 128
Y680
I
E
E
R
R
V
I
Y
V
G
K
I
R
P
D
Site 129
T688
V
G
K
I
R
P
D
T
T
R
T
E
L
R
D
Site 130
T707
F
G
E
I
E
E
C
T
V
N
L
R
D
D
G
Site 131
S716
N
L
R
D
D
G
D
S
Y
G
F
I
T
Y
R
Site 132
Y717
L
R
D
D
G
D
S
Y
G
F
I
T
Y
R
Y
Site 133
T721
G
D
S
Y
G
F
I
T
Y
R
Y
T
C
D
A
Site 134
Y722
D
S
Y
G
F
I
T
Y
R
Y
T
C
D
A
F
Site 135
T737
A
A
L
E
N
G
Y
T
L
R
R
S
N
E
T
Site 136
S741
N
G
Y
T
L
R
R
S
N
E
T
D
F
E
L
Site 137
T744
T
L
R
R
S
N
E
T
D
F
E
L
Y
F
C
Site 138
Y749
N
E
T
D
F
E
L
Y
F
C
G
R
K
Q
F
Site 139
S759
G
R
K
Q
F
F
K
S
N
Y
A
D
L
D
S
Site 140
Y761
K
Q
F
F
K
S
N
Y
A
D
L
D
S
N
S
Site 141
S766
S
N
Y
A
D
L
D
S
N
S
D
D
F
D
P
Site 142
S768
Y
A
D
L
D
S
N
S
D
D
F
D
P
A
S
Site 143
S775
S
D
D
F
D
P
A
S
T
K
S
K
Y
D
S
Site 144
S778
F
D
P
A
S
T
K
S
K
Y
D
S
L
D
F
Site 145
Y780
P
A
S
T
K
S
K
Y
D
S
L
D
F
D
S
Site 146
S782
S
T
K
S
K
Y
D
S
L
D
F
D
S
L
L
Site 147
S787
Y
D
S
L
D
F
D
S
L
L
K
E
A
Q
R
Site 148
S795
L
L
K
E
A
Q
R
S
L
R
R
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation