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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPSF2
Full Name:
Cleavage and polyadenylation specificity factor subunit 2
Alias:
Cleavage and polyadenylation specific factor 2, 100kDa; Cleavage and polyadenylation specificity factor subunit 2: Cleavage and polyadenylation specificity factor 100 kDa subunit; Cleavage and polyadenylation specificity factor, 100 kDa subunit; CPSB; CPSF 100 kDa subunit; CPSF100; KIAA1367
Type:
RNA binding protein
Mass (Da):
88487
Number AA:
782
UniProt ID:
Q9P2I0
International Prot ID:
IPI00419531
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0016787
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
Q
E
E
S
A
L
C
Y
L
L
Q
V
D
E
F
Site 2
T87
L
N
C
A
I
Y
A
T
I
P
V
Y
K
M
G
Site 3
Y102
Q
M
F
M
Y
D
L
Y
Q
S
R
H
N
T
E
Site 4
T108
L
Y
Q
S
R
H
N
T
E
D
F
T
L
F
T
Site 5
T112
R
H
N
T
E
D
F
T
L
F
T
L
D
D
V
Site 6
S132
K
I
Q
Q
L
K
F
S
Q
I
V
N
L
K
G
Site 7
S145
K
G
K
G
H
G
L
S
I
T
P
L
P
A
G
Site 8
T147
K
G
H
G
L
S
I
T
P
L
P
A
G
H
M
Site 9
Y172
D
G
E
E
E
I
V
Y
A
V
D
F
N
H
K
Site 10
S188
E
I
H
L
N
G
C
S
L
E
M
L
S
R
P
Site 11
T200
S
R
P
S
L
L
I
T
D
S
F
N
A
T
Y
Site 12
T206
I
T
D
S
F
N
A
T
Y
V
Q
P
R
R
K
Site 13
Y207
T
D
S
F
N
A
T
Y
V
Q
P
R
R
K
Q
Site 14
T221
Q
R
D
E
Q
L
L
T
N
V
L
E
T
L
R
Site 15
S282
N
V
V
E
F
S
K
S
Q
V
E
W
M
S
D
Site 16
S309
P
F
Q
F
R
H
L
S
L
C
H
G
L
S
D
Site 17
S329
S
P
K
V
V
L
A
S
Q
P
D
L
E
C
G
Site 18
T356
P
K
N
S
I
I
L
T
Y
R
T
T
P
G
T
Site 19
T359
S
I
I
L
T
Y
R
T
T
P
G
T
L
A
R
Site 20
T360
I
I
L
T
Y
R
T
T
P
G
T
L
A
R
F
Site 21
T363
T
Y
R
T
T
P
G
T
L
A
R
F
L
I
D
Site 22
S373
R
F
L
I
D
N
P
S
E
K
I
T
E
I
E
Site 23
T377
D
N
P
S
E
K
I
T
E
I
E
L
R
K
R
Site 24
Y395
E
G
K
E
L
E
E
Y
L
E
K
E
K
L
K
Site 25
S412
A
A
K
K
L
E
Q
S
K
E
A
D
I
D
S
Site 26
S419
S
K
E
A
D
I
D
S
S
D
E
S
D
I
E
Site 27
S420
K
E
A
D
I
D
S
S
D
E
S
D
I
E
E
Site 28
S423
D
I
D
S
S
D
E
S
D
I
E
E
D
I
D
Site 29
S433
E
E
D
I
D
Q
P
S
A
H
K
T
K
H
D
Site 30
T437
D
Q
P
S
A
H
K
T
K
H
D
L
M
M
K
Site 31
S448
L
M
M
K
G
E
G
S
R
K
G
S
F
F
K
Site 32
S452
G
E
G
S
R
K
G
S
F
F
K
Q
A
K
K
Site 33
S460
F
F
K
Q
A
K
K
S
Y
P
M
F
P
A
P
Site 34
Y476
E
R
I
K
W
D
E
Y
G
E
I
I
K
P
E
Site 35
T493
L
V
P
E
L
Q
A
T
E
E
E
K
S
K
L
Site 36
S498
Q
A
T
E
E
E
K
S
K
L
E
S
G
L
T
Site 37
S502
E
E
K
S
K
L
E
S
G
L
T
N
G
D
E
Site 38
T505
S
K
L
E
S
G
L
T
N
G
D
E
P
M
D
Site 39
S516
E
P
M
D
Q
D
L
S
D
V
P
T
K
C
I
Site 40
T520
Q
D
L
S
D
V
P
T
K
C
I
S
T
T
E
Site 41
S524
D
V
P
T
K
C
I
S
T
T
E
S
I
E
I
Site 42
S528
K
C
I
S
T
T
E
S
I
E
I
K
A
R
V
Site 43
T536
I
E
I
K
A
R
V
T
Y
I
D
Y
E
G
R
Site 44
Y537
E
I
K
A
R
V
T
Y
I
D
Y
E
G
R
S
Site 45
Y540
A
R
V
T
Y
I
D
Y
E
G
R
S
D
G
D
Site 46
S544
Y
I
D
Y
E
G
R
S
D
G
D
S
I
K
K
Site 47
S548
E
G
R
S
D
G
D
S
I
K
K
I
I
N
Q
Site 48
S571
V
H
G
P
P
E
A
S
Q
D
L
A
E
C
C
Site 49
Y589
G
G
K
D
I
K
V
Y
M
P
K
L
H
E
T
Site 50
T596
Y
M
P
K
L
H
E
T
V
D
A
T
S
E
T
Site 51
S601
H
E
T
V
D
A
T
S
E
T
H
I
Y
Q
V
Site 52
Y606
A
T
S
E
T
H
I
Y
Q
V
R
L
K
D
S
Site 53
S613
Y
Q
V
R
L
K
D
S
L
V
S
S
L
Q
F
Site 54
S617
L
K
D
S
L
V
S
S
L
Q
F
C
K
A
K
Site 55
S660
L
K
D
D
G
E
D
S
E
M
Q
V
E
A
P
Site 56
S668
E
M
Q
V
E
A
P
S
D
S
S
V
I
A
Q
Site 57
S671
V
E
A
P
S
D
S
S
V
I
A
Q
Q
K
A
Site 58
S681
A
Q
Q
K
A
M
K
S
L
F
G
D
D
E
K
Site 59
T699
E
E
S
E
I
I
P
T
L
E
P
L
P
P
H
Site 60
S722
F
M
N
E
P
R
L
S
D
F
K
Q
V
L
L
Site 61
T753
N
Q
V
A
V
R
R
T
E
T
G
R
I
G
L
Site 62
T755
V
A
V
R
R
T
E
T
G
R
I
G
L
E
G
Site 63
Y776
Y
R
I
R
D
L
L
Y
E
Q
Y
A
I
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation