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Updated November 2019
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Protein Info
Short Name:
CCDC88C
Full Name:
Protein Daple
Alias:
Coiled-coil domain containing 88C; DAPLE; Dvl-associating protein with a high frequency of leucine residues; HkRP2; Hook-related 2; KIAA1509
Type:
Inhibitor protein
Mass (Da):
228214
Number AA:
2028
UniProt ID:
Q9P219
International Prot ID:
IPI00029170
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005626
Uniprot
OncoNet
Molecular Function:
GO:0030165
GO:0043621
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0031648
GO:0051260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
K
T
F
G
P
F
G
S
G
S
Q
D
N
L
T
Site 2
S31
F
G
P
F
G
S
G
S
Q
D
N
L
T
M
Y
Site 3
T36
S
G
S
Q
D
N
L
T
M
Y
M
D
L
V
D
Site 4
Y38
S
Q
D
N
L
T
M
Y
M
D
L
V
D
G
I
Site 5
T59
L
Q
I
D
P
R
P
T
N
Q
R
I
N
K
H
Site 6
T87
I
L
V
R
N
I
K
T
Y
Y
Q
E
V
L
Q
Site 7
Y88
L
V
R
N
I
K
T
Y
Y
Q
E
V
L
Q
Q
Site 8
Y89
V
R
N
I
K
T
Y
Y
Q
E
V
L
Q
Q
L
Site 9
S113
M
I
G
R
D
P
L
S
G
K
S
M
E
E
I
Site 10
S116
R
D
P
L
S
G
K
S
M
E
E
I
K
K
V
Site 11
S189
P
E
E
L
E
A
L
S
R
S
M
V
L
H
L
Site 12
S191
E
L
E
A
L
S
R
S
M
V
L
H
L
R
R
Site 13
T214
T
E
L
I
V
D
L
T
Q
E
R
D
Y
L
Q
Site 14
Y219
D
L
T
Q
E
R
D
Y
L
Q
A
Q
H
P
P
Site 15
S227
L
Q
A
Q
H
P
P
S
P
I
K
S
S
S
A
Site 16
S231
H
P
P
S
P
I
K
S
S
S
A
D
S
T
P
Site 17
S232
P
P
S
P
I
K
S
S
S
A
D
S
T
P
S
Site 18
S233
P
S
P
I
K
S
S
S
A
D
S
T
P
S
P
Site 19
S236
I
K
S
S
S
A
D
S
T
P
S
P
T
S
S
Site 20
T237
K
S
S
S
A
D
S
T
P
S
P
T
S
S
L
Site 21
S239
S
S
A
D
S
T
P
S
P
T
S
S
L
S
S
Site 22
T241
A
D
S
T
P
S
P
T
S
S
L
S
S
E
D
Site 23
S242
D
S
T
P
S
P
T
S
S
L
S
S
E
D
K
Site 24
S243
S
T
P
S
P
T
S
S
L
S
S
E
D
K
Q
Site 25
S245
P
S
P
T
S
S
L
S
S
E
D
K
Q
H
L
Site 26
S246
S
P
T
S
S
L
S
S
E
D
K
Q
H
L
A
Site 27
T259
L
A
V
E
L
A
D
T
K
A
R
L
R
R
V
Site 28
T274
R
Q
E
L
E
D
K
T
E
Q
L
V
D
T
R
Site 29
S307
Q
L
A
A
D
A
R
S
A
R
A
Y
R
D
E
Site 30
Y311
D
A
R
S
A
R
A
Y
R
D
E
L
D
S
L
Site 31
S317
A
Y
R
D
E
L
D
S
L
R
E
K
A
N
R
Site 32
T333
E
R
L
E
L
E
L
T
R
C
K
E
K
L
H
Site 33
Y345
K
L
H
D
V
D
F
Y
K
A
R
M
E
E
L
Site 34
T371
A
M
L
E
E
Q
L
T
A
A
R
A
R
G
D
Site 35
T403
D
L
E
L
D
R
D
T
D
K
K
R
I
E
E
Site 36
S425
L
E
I
A
Q
K
Q
S
M
N
E
S
A
H
L
Site 37
S429
Q
K
Q
S
M
N
E
S
A
H
L
G
W
E
L
Site 38
S440
G
W
E
L
E
Q
L
S
K
N
A
D
L
S
D
Site 39
S446
L
S
K
N
A
D
L
S
D
A
S
R
K
S
F
Site 40
S452
L
S
D
A
S
R
K
S
F
V
F
E
L
N
E
Site 41
S462
F
E
L
N
E
C
A
S
S
R
I
L
K
L
E
Site 42
S463
E
L
N
E
C
A
S
S
R
I
L
K
L
E
K
Site 43
S474
K
L
E
K
E
N
Q
S
L
Q
S
T
I
Q
G
Site 44
T478
E
N
Q
S
L
Q
S
T
I
Q
G
L
R
D
A
Site 45
S486
I
Q
G
L
R
D
A
S
L
V
L
E
E
S
G
Site 46
S507
E
K
E
N
H
Q
L
S
K
K
I
E
K
L
Q
Site 47
T515
K
K
I
E
K
L
Q
T
Q
L
E
R
E
K
Q
Site 48
T529
Q
S
N
Q
D
L
E
T
L
S
E
E
L
I
R
Site 49
S543
R
E
K
E
Q
L
Q
S
D
M
E
T
L
K
A
Site 50
T547
Q
L
Q
S
D
M
E
T
L
K
A
D
K
A
R
Site 51
S572
H
L
N
R
A
M
W
S
L
R
E
R
S
Q
V
Site 52
S577
M
W
S
L
R
E
R
S
Q
V
S
S
E
A
R
Site 53
S580
L
R
E
R
S
Q
V
S
S
E
A
R
M
K
D
Site 54
S581
R
E
R
S
Q
V
S
S
E
A
R
M
K
D
V
Site 55
T598
E
N
K
A
L
H
Q
T
V
T
E
A
N
G
K
Site 56
S607
T
E
A
N
G
K
L
S
Q
L
E
F
E
K
R
Site 57
T652
G
R
L
A
R
K
V
T
S
L
E
T
A
T
E
Site 58
S653
R
L
A
R
K
V
T
S
L
E
T
A
T
E
K
Site 59
T677
G
L
Q
L
E
N
R
T
L
R
K
S
L
D
T
Site 60
S681
E
N
R
T
L
R
K
S
L
D
T
L
Q
N
V
Site 61
T684
T
L
R
K
S
L
D
T
L
Q
N
V
S
L
Q
Site 62
T715
E
L
R
R
L
V
E
T
M
R
F
T
S
T
K
Site 63
S720
V
E
T
M
R
F
T
S
T
K
L
A
Q
M
E
Site 64
S754
L
K
A
L
G
K
K
S
E
R
L
E
L
S
Y
Site 65
S760
K
S
E
R
L
E
L
S
Y
Q
S
V
S
A
E
Site 66
Y761
S
E
R
L
E
L
S
Y
Q
S
V
S
A
E
N
Site 67
S763
R
L
E
L
S
Y
Q
S
V
S
A
E
N
L
R
Site 68
S774
E
N
L
R
L
Q
Q
S
L
E
S
S
S
H
K
Site 69
S778
L
Q
Q
S
L
E
S
S
S
H
K
T
Q
T
L
Site 70
T782
L
E
S
S
S
H
K
T
Q
T
L
E
S
E
L
Site 71
T784
S
S
S
H
K
T
Q
T
L
E
S
E
L
G
E
Site 72
S787
H
K
T
Q
T
L
E
S
E
L
G
E
L
E
A
Site 73
S858
K
D
A
V
L
D
D
S
T
A
K
L
S
A
V
Site 74
T859
D
A
V
L
D
D
S
T
A
K
L
S
A
V
E
Site 75
S863
D
D
S
T
A
K
L
S
A
V
E
K
E
S
R
Site 76
T897
E
K
D
N
R
D
L
T
K
Q
V
T
V
H
A
Site 77
T901
R
D
L
T
K
Q
V
T
V
H
A
R
T
L
T
Site 78
T908
T
V
H
A
R
T
L
T
T
L
R
E
D
L
V
Site 79
S921
L
V
L
E
K
L
K
S
Q
Q
L
S
S
E
L
Site 80
S925
K
L
K
S
Q
Q
L
S
S
E
L
D
K
L
S
Site 81
S926
L
K
S
Q
Q
L
S
S
E
L
D
K
L
S
Q
Site 82
S932
S
S
E
L
D
K
L
S
Q
E
L
E
K
V
G
Site 83
S951
L
L
L
Q
E
D
D
S
G
S
D
T
K
Y
K
Site 84
S953
L
Q
E
D
D
S
G
S
D
T
K
Y
K
I
L
Site 85
T955
E
D
D
S
G
S
D
T
K
Y
K
I
L
E
G
Site 86
Y957
D
S
G
S
D
T
K
Y
K
I
L
E
G
R
N
Site 87
S966
I
L
E
G
R
N
E
S
A
L
K
T
T
L
A
Site 88
T970
R
N
E
S
A
L
K
T
T
L
A
M
K
E
E
Site 89
S991
A
Q
M
E
E
K
A
S
L
N
R
Q
L
E
S
Site 90
S1023
E
G
Q
H
L
Q
N
S
F
K
H
P
A
G
K
Site 91
S1034
P
A
G
K
T
A
A
S
H
Q
G
K
E
A
W
Site 92
T1085
E
Q
L
Q
H
L
E
T
Q
N
V
T
F
S
S
Site 93
T1089
H
L
E
T
Q
N
V
T
F
S
S
Q
I
L
T
Site 94
S1092
T
Q
N
V
T
F
S
S
Q
I
L
T
L
Q
K
Site 95
T1096
T
F
S
S
Q
I
L
T
L
Q
K
Q
S
A
F
Site 96
T1110
F
L
Q
E
H
N
T
T
L
Q
T
Q
T
A
K
Site 97
S1123
A
K
L
Q
V
E
N
S
T
L
S
S
Q
S
A
Site 98
T1124
K
L
Q
V
E
N
S
T
L
S
S
Q
S
A
A
Site 99
S1127
V
E
N
S
T
L
S
S
Q
S
A
A
L
T
A
Site 100
T1133
S
S
Q
S
A
A
L
T
A
Q
Y
T
L
L
Q
Site 101
T1137
A
A
L
T
A
Q
Y
T
L
L
Q
N
H
H
T
Site 102
S1152
A
K
E
T
E
N
E
S
L
Q
R
Q
Q
E
Q
Site 103
T1176
Q
D
H
E
H
L
G
T
L
H
E
R
Q
S
A
Site 104
S1182
G
T
L
H
E
R
Q
S
A
E
Y
E
A
L
I
Site 105
Y1185
H
E
R
Q
S
A
E
Y
E
A
L
I
R
Q
H
Site 106
S1193
E
A
L
I
R
Q
H
S
C
L
K
T
L
H
R
Site 107
T1197
R
Q
H
S
C
L
K
T
L
H
R
N
L
E
L
Site 108
T1231
E
E
R
E
K
V
L
T
T
E
R
E
A
L
Q
Site 109
T1232
E
R
E
K
V
L
T
T
E
R
E
A
L
Q
Q
Site 110
S1285
H
T
K
E
L
K
T
S
L
N
N
A
Q
L
E
Site 111
T1309
E
L
K
E
Q
H
Q
T
M
D
I
S
L
T
K
Site 112
S1340
E
E
N
H
H
L
L
S
Q
I
Q
L
L
S
Q
Site 113
Y1370
Y
H
E
E
Q
K
Q
Y
I
D
K
L
N
A
L
Site 114
Y1392
E
E
K
I
M
D
Q
Y
K
F
Y
D
P
P
P
Site 115
Y1395
I
M
D
Q
Y
K
F
Y
D
P
P
P
K
K
K
Site 116
S1422
I
K
P
K
K
E
G
S
R
E
R
L
K
S
T
Site 117
S1428
G
S
R
E
R
L
K
S
T
V
D
S
P
P
W
Site 118
T1429
S
R
E
R
L
K
S
T
V
D
S
P
P
W
Q
Site 119
S1432
R
L
K
S
T
V
D
S
P
P
W
Q
L
E
S
Site 120
S1439
S
P
P
W
Q
L
E
S
S
D
P
A
S
P
A
Site 121
S1440
P
P
W
Q
L
E
S
S
D
P
A
S
P
A
A
Site 122
S1444
L
E
S
S
D
P
A
S
P
A
A
S
Q
P
L
Site 123
S1448
D
P
A
S
P
A
A
S
Q
P
L
R
S
Q
A
Site 124
S1453
A
A
S
Q
P
L
R
S
Q
A
E
N
P
D
T
Site 125
T1460
S
Q
A
E
N
P
D
T
P
A
L
G
S
N
C
Site 126
S1477
E
R
D
A
H
N
G
S
V
G
K
G
P
G
D
Site 127
S1491
D
L
K
P
K
R
G
S
P
H
R
G
S
L
D
Site 128
S1496
R
G
S
P
H
R
G
S
L
D
R
T
D
A
S
Site 129
T1500
H
R
G
S
L
D
R
T
D
A
S
T
D
L
A
Site 130
S1503
S
L
D
R
T
D
A
S
T
D
L
A
M
R
S
Site 131
T1504
L
D
R
T
D
A
S
T
D
L
A
M
R
S
W
Site 132
S1510
S
T
D
L
A
M
R
S
W
P
S
E
L
G
S
Site 133
S1513
L
A
M
R
S
W
P
S
E
L
G
S
R
T
C
Site 134
S1517
S
W
P
S
E
L
G
S
R
T
C
S
T
S
A
Site 135
T1519
P
S
E
L
G
S
R
T
C
S
T
S
A
T
T
Site 136
S1521
E
L
G
S
R
T
C
S
T
S
A
T
T
T
A
Site 137
S1523
G
S
R
T
C
S
T
S
A
T
T
T
A
P
S
Site 138
T1525
R
T
C
S
T
S
A
T
T
T
A
P
S
N
S
Site 139
T1526
T
C
S
T
S
A
T
T
T
A
P
S
N
S
T
Site 140
T1527
C
S
T
S
A
T
T
T
A
P
S
N
S
T
P
Site 141
S1530
S
A
T
T
T
A
P
S
N
S
T
P
I
A
R
Site 142
S1532
T
T
T
A
P
S
N
S
T
P
I
A
R
H
P
Site 143
T1533
T
T
A
P
S
N
S
T
P
I
A
R
H
P
G
Site 144
T1542
I
A
R
H
P
G
R
T
K
G
Y
N
S
D
D
Site 145
S1547
G
R
T
K
G
Y
N
S
D
D
N
L
C
E
P
Site 146
Y1566
E
V
P
N
H
R
Q
Y
V
S
R
P
S
S
L
Site 147
S1568
P
N
H
R
Q
Y
V
S
R
P
S
S
L
E
S
Site 148
S1571
R
Q
Y
V
S
R
P
S
S
L
E
S
S
R
N
Site 149
S1572
Q
Y
V
S
R
P
S
S
L
E
S
S
R
N
T
Site 150
S1575
S
R
P
S
S
L
E
S
S
R
N
T
S
S
N
Site 151
S1576
R
P
S
S
L
E
S
S
R
N
T
S
S
N
S
Site 152
T1579
S
L
E
S
S
R
N
T
S
S
N
S
S
P
L
Site 153
S1580
L
E
S
S
R
N
T
S
S
N
S
S
P
L
N
Site 154
S1581
E
S
S
R
N
T
S
S
N
S
S
P
L
N
L
Site 155
S1583
S
R
N
T
S
S
N
S
S
P
L
N
L
K
G
Site 156
S1584
R
N
T
S
S
N
S
S
P
L
N
L
K
G
S
Site 157
S1591
S
P
L
N
L
K
G
S
S
E
Q
L
H
G
R
Site 158
S1599
S
E
Q
L
H
G
R
S
E
S
F
S
S
E
D
Site 159
S1601
Q
L
H
G
R
S
E
S
F
S
S
E
D
L
I
Site 160
S1603
H
G
R
S
E
S
F
S
S
E
D
L
I
P
S
Site 161
S1604
G
R
S
E
S
F
S
S
E
D
L
I
P
S
R
Site 162
S1610
S
S
E
D
L
I
P
S
R
D
L
A
T
L
P
Site 163
T1615
I
P
S
R
D
L
A
T
L
P
R
E
A
S
T
Site 164
S1621
A
T
L
P
R
E
A
S
T
P
G
R
N
A
L
Site 165
T1622
T
L
P
R
E
A
S
T
P
G
R
N
A
L
G
Site 166
Y1633
N
A
L
G
R
H
E
Y
P
L
P
R
N
G
P
Site 167
T1651
E
G
A
Q
K
R
G
T
A
P
P
Y
V
G
V
Site 168
Y1655
K
R
G
T
A
P
P
Y
V
G
V
R
P
C
S
Site 169
S1662
Y
V
G
V
R
P
C
S
A
S
P
S
S
E
M
Site 170
S1664
G
V
R
P
C
S
A
S
P
S
S
E
M
V
T
Site 171
S1666
R
P
C
S
A
S
P
S
S
E
M
V
T
L
E
Site 172
S1667
P
C
S
A
S
P
S
S
E
M
V
T
L
E
E
Site 173
T1671
S
P
S
S
E
M
V
T
L
E
E
F
L
E
E
Site 174
S1679
L
E
E
F
L
E
E
S
N
R
S
S
P
T
H
Site 175
S1682
F
L
E
E
S
N
R
S
S
P
T
H
D
T
P
Site 176
S1683
L
E
E
S
N
R
S
S
P
T
H
D
T
P
S
Site 177
T1688
R
S
S
P
T
H
D
T
P
S
C
R
D
D
L
Site 178
S1690
S
P
T
H
D
T
P
S
C
R
D
D
L
L
S
Site 179
S1697
S
C
R
D
D
L
L
S
D
Y
F
R
K
A
S
Site 180
Y1699
R
D
D
L
L
S
D
Y
F
R
K
A
S
D
P
Site 181
S1704
S
D
Y
F
R
K
A
S
D
P
P
A
I
G
G
Site 182
S1740
V
K
M
A
A
P
T
S
E
G
R
P
L
K
P
Site 183
Y1750
R
P
L
K
P
G
Q
Y
V
K
P
N
F
R
L
Site 184
T1758
V
K
P
N
F
R
L
T
E
A
E
A
P
P
S
Site 185
S1765
T
E
A
E
A
P
P
S
V
A
P
R
Q
A
Q
Site 186
S1776
R
Q
A
Q
P
P
Q
S
L
S
L
G
R
P
R
Site 187
S1778
A
Q
P
P
Q
S
L
S
L
G
R
P
R
Q
A
Site 188
S1791
Q
A
P
V
P
P
A
S
H
A
P
A
S
R
S
Site 189
S1796
P
A
S
H
A
P
A
S
R
S
A
S
L
S
R
Site 190
S1798
S
H
A
P
A
S
R
S
A
S
L
S
R
A
F
Site 191
S1800
A
P
A
S
R
S
A
S
L
S
R
A
F
S
L
Site 192
S1802
A
S
R
S
A
S
L
S
R
A
F
S
L
A
S
Site 193
S1806
A
S
L
S
R
A
F
S
L
A
S
A
D
L
L
Site 194
S1816
S
A
D
L
L
R
A
S
G
P
E
A
C
K
Q
Site 195
S1825
P
E
A
C
K
Q
E
S
P
Q
K
L
G
A
P
Site 196
T1840
E
A
L
G
G
R
E
T
G
S
H
T
L
Q
S
Site 197
S1842
L
G
G
R
E
T
G
S
H
T
L
Q
S
P
A
Site 198
S1847
T
G
S
H
T
L
Q
S
P
A
P
P
S
S
H
Site 199
S1852
L
Q
S
P
A
P
P
S
S
H
S
L
A
R
E
Site 200
S1853
Q
S
P
A
P
P
S
S
H
S
L
A
R
E
R
Site 201
S1855
P
A
P
P
S
S
H
S
L
A
R
E
R
T
P
Site 202
T1861
H
S
L
A
R
E
R
T
P
L
V
G
K
A
G
Site 203
S1869
P
L
V
G
K
A
G
S
S
C
Q
G
P
G
P
Site 204
S1870
L
V
G
K
A
G
S
S
C
Q
G
P
G
P
R
Site 205
S1878
C
Q
G
P
G
P
R
S
R
P
L
D
T
R
R
Site 206
T1883
P
R
S
R
P
L
D
T
R
R
F
S
L
A
P
Site 207
S1887
P
L
D
T
R
R
F
S
L
A
P
P
K
E
E
Site 208
S1924
A
A
G
S
G
S
N
S
Q
L
L
H
F
S
P
Site 209
S1947
K
P
K
A
P
P
R
S
G
E
V
A
T
I
T
Site 210
S1961
T
P
V
R
A
G
L
S
L
S
E
G
D
G
V
Site 211
S1963
V
R
A
G
L
S
L
S
E
G
D
G
V
P
G
Site 212
S1981
S
E
G
L
P
A
K
S
P
G
R
S
P
D
L
Site 213
S1985
P
A
K
S
P
G
R
S
P
D
L
A
P
H
P
Site 214
S2000
G
R
A
L
E
D
C
S
R
G
S
V
S
K
S
Site 215
S2003
L
E
D
C
S
R
G
S
V
S
K
S
S
P
A
Site 216
S2005
D
C
S
R
G
S
V
S
K
S
S
P
A
S
P
Site 217
S2007
S
R
G
S
V
S
K
S
S
P
A
S
P
E
P
Site 218
S2008
R
G
S
V
S
K
S
S
P
A
S
P
E
P
G
Site 219
S2011
V
S
K
S
S
P
A
S
P
E
P
G
G
D
P
Site 220
T2020
E
P
G
G
D
P
Q
T
V
W
Y
E
Y
G
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation