PhosphoNET

           
Protein Info 
   
Short Name:  EIF2AK3
Full Name:  Eukaryotic translation initiation factor 2-alpha kinase 3
Alias:  E2AK3; EC 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; Kinase PERK; Pancreatic eIF2-alpha kinase; PEK; PRKR-like endoplasmic reticulum kinase
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; PEK family; PEK subfamily
Mass (Da):  125147
Number AA:  1115
UniProt ID:  Q9NZJ5
International Prot ID:  IPI00303053
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005789  GO:0016021   Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004694  GO:0042802 PhosphoSite+ KinaseNET
Biological Process:  GO:0006983  GO:0006919  GO:0030282 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S139GSGSLVSSSLSKPEV
Site 2S140SGSLVSSSLSKPEVF
Site 3S169QWDRDRESMETVPFT
Site 4T172RDRESMETVPFTVES
Site 5S184VESLLESSYKFGDDV
Site 6T201VGGKSLTTYGLSAYS
Site 7S399GQLYLQSSVRISEKF
Site 8S409ISEKFPSSPKALESV
Site 9Y480YPYDNGYYLPYYKRE
Site 10Y484NGYYLPYYKRERNKR
Site 11S575SGEANDSSWNDIKNS
Site 12S685STDWPLSSPSPMDAP
Site 13S703IRRMDPFSTKEHIEI
Site 14S732ISCDQTSSSESQFSP
Site 15S733SCDQTSSSESQFSPL
Site 16S803RSRERTSSSIVFEDS
Site 17S804RSRERTSSSIVFEDS
Site 18S817SGCDNASSKEEPKTN
Site 19S844TAFKPTSSKSSSEAT
Site 20S847KPTSSKSSSEATLSI
Site 21S848PTSSKSSSEATLSIS
Site 22T861ISPPRPTTLSLDLTK
Site 23S878TEKLQPSSPKVYLYI
Site 24S1096QRSRSLSSSGTKHSR
Site 25S1097RSRSLSSSGTKHSRQ
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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