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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TAB2
Full Name:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Alias:
KIAA0733; MAP3K7IP2; Mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7 interacting protein 2, isoform 1; TAK1-binding protein 2
Type:
Adapter/scaffold protein
Mass (Da):
76494
Number AA:
693
UniProt ID:
Q9NYJ8
International Prot ID:
IPI00419504
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0043123
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
D
A
C
C
A
V
L
S
Q
E
S
T
R
Y
L
Site 2
T51
A
V
L
S
Q
E
S
T
R
Y
L
Y
G
E
G
Site 3
Y53
L
S
Q
E
S
T
R
Y
L
Y
G
E
G
D
L
Site 4
Y55
Q
E
S
T
R
Y
L
Y
G
E
G
D
L
N
F
Site 5
S63
G
E
G
D
L
N
F
S
D
D
S
G
I
S
G
Site 6
S66
D
L
N
F
S
D
D
S
G
I
S
G
L
R
N
Site 7
T76
S
G
L
R
N
H
M
T
S
L
N
L
D
L
Q
Site 8
S77
G
L
R
N
H
M
T
S
L
N
L
D
L
Q
S
Site 9
S84
S
L
N
L
D
L
Q
S
Q
N
I
Y
H
H
G
Site 10
Y88
D
L
Q
S
Q
N
I
Y
H
H
G
R
E
G
S
Site 11
S95
Y
H
H
G
R
E
G
S
R
M
N
G
S
R
T
Site 12
T102
S
R
M
N
G
S
R
T
L
T
H
S
I
S
D
Site 13
T104
M
N
G
S
R
T
L
T
H
S
I
S
D
G
Q
Site 14
S106
G
S
R
T
L
T
H
S
I
S
D
G
Q
L
Q
Site 15
S108
R
T
L
T
H
S
I
S
D
G
Q
L
Q
G
G
Site 16
S117
G
Q
L
Q
G
G
Q
S
N
S
E
L
F
Q
Q
Site 17
S119
L
Q
G
G
Q
S
N
S
E
L
F
Q
Q
E
P
Site 18
S143
G
F
N
V
F
G
M
S
S
S
S
G
A
S
N
Site 19
S144
F
N
V
F
G
M
S
S
S
S
G
A
S
N
S
Site 20
S145
N
V
F
G
M
S
S
S
S
G
A
S
N
S
A
Site 21
S146
V
F
G
M
S
S
S
S
G
A
S
N
S
A
P
Site 22
S149
M
S
S
S
S
G
A
S
N
S
A
P
H
L
G
Site 23
S151
S
S
S
G
A
S
N
S
A
P
H
L
G
F
H
Site 24
S161
H
L
G
F
H
L
G
S
K
G
T
S
S
L
S
Site 25
S165
H
L
G
S
K
G
T
S
S
L
S
Q
Q
T
P
Site 26
S166
L
G
S
K
G
T
S
S
L
S
Q
Q
T
P
R
Site 27
S168
S
K
G
T
S
S
L
S
Q
Q
T
P
R
F
N
Site 28
T171
T
S
S
L
S
Q
Q
T
P
R
F
N
P
I
M
Site 29
T191
N
I
Q
T
G
R
N
T
P
T
S
L
H
I
H
Site 30
S194
T
G
R
N
T
P
T
S
L
H
I
H
G
V
P
Site 31
S207
V
P
P
P
V
L
N
S
P
Q
G
N
S
I
Y
Site 32
S212
L
N
S
P
Q
G
N
S
I
Y
I
R
P
Y
I
Site 33
Y214
S
P
Q
G
N
S
I
Y
I
R
P
Y
I
T
T
Site 34
Y218
N
S
I
Y
I
R
P
Y
I
T
T
P
G
G
T
Site 35
T221
Y
I
R
P
Y
I
T
T
P
G
G
T
T
R
Q
Site 36
T229
P
G
G
T
T
R
Q
T
Q
Q
H
S
G
W
V
Site 37
Y248
P
M
N
P
Q
Q
V
Y
Q
P
S
Q
P
G
P
Site 38
S251
P
Q
Q
V
Y
Q
P
S
Q
P
G
P
W
T
T
Site 39
T257
P
S
Q
P
G
P
W
T
T
C
P
A
S
N
P
Site 40
T258
S
Q
P
G
P
W
T
T
C
P
A
S
N
P
L
Site 41
S262
P
W
T
T
C
P
A
S
N
P
L
S
H
T
S
Site 42
S266
C
P
A
S
N
P
L
S
H
T
S
S
Q
Q
P
Site 43
S270
N
P
L
S
H
T
S
S
Q
Q
P
N
Q
Q
G
Site 44
Y284
G
H
Q
T
S
H
V
Y
M
P
I
S
S
P
T
Site 45
S288
S
H
V
Y
M
P
I
S
S
P
T
T
S
Q
P
Site 46
S289
H
V
Y
M
P
I
S
S
P
T
T
S
Q
P
P
Site 47
T292
M
P
I
S
S
P
T
T
S
Q
P
P
T
I
H
Site 48
S293
P
I
S
S
P
T
T
S
Q
P
P
T
I
H
S
Site 49
T297
P
T
T
S
Q
P
P
T
I
H
S
S
G
S
S
Site 50
S300
S
Q
P
P
T
I
H
S
S
G
S
S
Q
S
S
Site 51
S301
Q
P
P
T
I
H
S
S
G
S
S
Q
S
S
A
Site 52
S303
P
T
I
H
S
S
G
S
S
Q
S
S
A
H
S
Site 53
S304
T
I
H
S
S
G
S
S
Q
S
S
A
H
S
Q
Site 54
S306
H
S
S
G
S
S
Q
S
S
A
H
S
Q
Y
N
Site 55
S307
S
S
G
S
S
Q
S
S
A
H
S
Q
Y
N
I
Site 56
S310
S
S
Q
S
S
A
H
S
Q
Y
N
I
Q
N
I
Site 57
S338
E
P
P
Q
R
N
N
S
S
K
L
R
S
S
G
Site 58
S339
P
P
Q
R
N
N
S
S
K
L
R
S
S
G
P
Site 59
S343
N
N
S
S
K
L
R
S
S
G
P
R
T
S
S
Site 60
S344
N
S
S
K
L
R
S
S
G
P
R
T
S
S
T
Site 61
T348
L
R
S
S
G
P
R
T
S
S
T
S
S
S
V
Site 62
S349
R
S
S
G
P
R
T
S
S
T
S
S
S
V
N
Site 63
S350
S
S
G
P
R
T
S
S
T
S
S
S
V
N
S
Site 64
T351
S
G
P
R
T
S
S
T
S
S
S
V
N
S
Q
Site 65
S352
G
P
R
T
S
S
T
S
S
S
V
N
S
Q
T
Site 66
S353
P
R
T
S
S
T
S
S
S
V
N
S
Q
T
L
Site 67
S354
R
T
S
S
T
S
S
S
V
N
S
Q
T
L
N
Site 68
S357
S
T
S
S
S
V
N
S
Q
T
L
N
R
N
Q
Site 69
T359
S
S
S
V
N
S
Q
T
L
N
R
N
Q
P
T
Site 70
Y368
N
R
N
Q
P
T
V
Y
I
A
A
S
P
P
N
Site 71
S372
P
T
V
Y
I
A
A
S
P
P
N
T
D
E
L
Site 72
T376
I
A
A
S
P
P
N
T
D
E
L
M
S
R
S
Site 73
S381
P
N
T
D
E
L
M
S
R
S
Q
P
K
V
Y
Site 74
S383
T
D
E
L
M
S
R
S
Q
P
K
V
Y
I
S
Site 75
T406
Q
V
M
R
N
Q
P
T
L
F
I
S
T
N
S
Site 76
S410
N
Q
P
T
L
F
I
S
T
N
S
G
A
S
A
Site 77
S413
T
L
F
I
S
T
N
S
G
A
S
A
A
S
R
Site 78
S419
N
S
G
A
S
A
A
S
R
N
M
S
G
Q
V
Site 79
S423
S
A
A
S
R
N
M
S
G
Q
V
S
M
G
P
Site 80
S427
R
N
M
S
G
Q
V
S
M
G
P
A
F
I
H
Site 81
S440
I
H
H
H
P
P
K
S
R
A
I
G
N
N
S
Site 82
S447
S
R
A
I
G
N
N
S
A
T
S
P
R
V
V
Site 83
T449
A
I
G
N
N
S
A
T
S
P
R
V
V
V
T
Site 84
S450
I
G
N
N
S
A
T
S
P
R
V
V
V
T
Q
Site 85
T456
T
S
P
R
V
V
V
T
Q
P
N
T
K
Y
T
Site 86
Y462
V
T
Q
P
N
T
K
Y
T
F
K
I
T
V
S
Site 87
T463
T
Q
P
N
T
K
Y
T
F
K
I
T
V
S
P
Site 88
T467
T
K
Y
T
F
K
I
T
V
S
P
N
K
P
P
Site 89
S469
Y
T
F
K
I
T
V
S
P
N
K
P
P
A
V
Site 90
S477
P
N
K
P
P
A
V
S
P
G
V
V
S
P
T
Site 91
S482
A
V
S
P
G
V
V
S
P
T
F
E
L
T
N
Site 92
T484
S
P
G
V
V
S
P
T
F
E
L
T
N
L
L
Site 93
Y497
L
L
N
H
P
D
H
Y
V
E
T
E
N
I
Q
Site 94
T510
I
Q
H
L
T
D
P
T
L
A
H
V
D
R
I
Site 95
S518
L
A
H
V
D
R
I
S
E
T
R
K
L
S
M
Site 96
S524
I
S
E
T
R
K
L
S
M
G
S
D
D
A
A
Site 97
S527
T
R
K
L
S
M
G
S
D
D
A
A
Y
T
Q
Site 98
Y532
M
G
S
D
D
A
A
Y
T
Q
A
L
L
V
H
Site 99
S563
K
K
L
D
K
L
K
S
E
V
N
E
M
E
N
Site 100
T573
N
E
M
E
N
N
L
T
R
R
R
L
K
R
S
Site 101
S580
T
R
R
R
L
K
R
S
N
S
I
S
Q
I
P
Site 102
S582
R
R
L
K
R
S
N
S
I
S
Q
I
P
S
L
Site 103
S584
L
K
R
S
N
S
I
S
Q
I
P
S
L
E
E
Site 104
S588
N
S
I
S
Q
I
P
S
L
E
E
M
Q
Q
L
Site 105
Y632
P
S
A
I
H
N
F
Y
D
N
I
G
F
V
G
Site 106
S650
P
K
P
K
D
Q
R
S
I
I
K
T
P
K
T
Site 107
T654
D
Q
R
S
I
I
K
T
P
K
T
Q
D
T
E
Site 108
T657
S
I
I
K
T
P
K
T
Q
D
T
E
D
D
E
Site 109
T660
K
T
P
K
T
Q
D
T
E
D
D
E
G
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation