PhosphoNET

           
Protein Info 
   
Short Name:  SH2B1
Full Name:  SH2B adapter protein 1
Alias:  DKFZP727I201; FLJ30542; SH2 domain-containing adaptor SH2-B beta; SH2B; SH2-B; SH2B adapter protein 1: SH2 domain-containing protein 1B: Pro-rich, PH and SH2 domain-containing signaling mediator: SH2B adapter protein 1: SH2 domain-containing protein 1B: Pro-rich, PH and SH2 domain-containing signaling mediator: SH2B adapter protein 1: SH2 domain-containing protein 1B: Pro-rich, PH and SH2 domain-containing signaling mediator; SH2B adaptor protein 1; SH2-B beta signaling protein
Type:  Adapter/scaffold protein
Mass (Da):  79336
Number AA:  756
UniProt ID:  Q9NRF2
International Prot ID:  not found
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0016020  GO:0005634 Uniprot OncoNet
Molecular Function:  GO:0005515  GO:0004871   PhosphoSite+ KinaseNET
Biological Process:  GO:0007242     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S6__MNGAPSPEDGASP
Site 2S12PSPEDGASPSSPPLP
Site 3S14PEDGASPSSPPLPPP
Site 4S15EDGASPSSPPLPPPP
Site 5S25LPPPPPPSWREFCES
Site 6S32SWREFCESHARAAAL
Site 7Y48FARRFRLYLASHPQY
Site 8S51RFRLYLASHPQYAGP
Site 9Y55YLASHPQYAGPGAEA
Site 10S65PGAEAAFSRRFAELF
Site 11S84EAEVARASGSLSPPI
Site 12S88ARASGSLSPPILAPL
Site 13S96PPILAPLSPGAEISP
Site 14S102LSPGAEISPHDLSLE
Site 15S107EISPHDLSLESCRVG
Site 16S110PHDLSLESCRVGGPL
Site 17S123PLAVLGPSRSSEDLA
Site 18S125AVLGPSRSSEDLAGP
Site 19S126VLGPSRSSEDLAGPL
Site 20S135DLAGPLPSSVSSSST
Site 21S136LAGPLPSSVSSSSTT
Site 22S138GPLPSSVSSSSTTSS
Site 23S139PLPSSVSSSSTTSSK
Site 24S140LPSSVSSSSTTSSKP
Site 25S141PSSVSSSSTTSSKPK
Site 26T142SSVSSSSTTSSKPKL
Site 27T143SVSSSSTTSSKPKLK
Site 28S144VSSSSTTSSKPKLKK
Site 29S145SSSSTTSSKPKLKKR
Site 30S154PKLKKRFSLRSVGRS
Site 31S157KKRFSLRSVGRSVRG
Site 32S161SLRSVGRSVRGSVRG
Site 33S165VGRSVRGSVRGILQW
Site 34T175GILQWRGTVDPPSSA
Site 35S180RGTVDPPSSAGPLET
Site 36S181GTVDPPSSAGPLETS
Site 37S188SAGPLETSSGPPVLG
Site 38S189AGPLETSSGPPVLGG
Site 39S198PPVLGGNSNSNSSGG
Site 40S200VLGGNSNSNSSGGAG
Site 41S202GGNSNSNSSGGAGTV
Site 42T208NSSGGAGTVGRGLVS
Site 43S215TVGRGLVSDGTSPGE
Site 44T218RGLVSDGTSPGERWT
Site 45S219GLVSDGTSPGERWTH
Site 46T225TSPGERWTHRFERLR
Site 47S234RFERLRLSRGGGALK
Site 48S254VQREELLSFMGAEEA
Site 49S279GGVAGPPSGGGGQPQ
Site 50S296KCRLLLRSEGEGGGG
Site 51S304EGEGGGGSRLEFFVP
Site 52S315FFVPPKASRPRLSIP
Site 53S320KASRPRLSIPCSSIT
Site 54S324PRLSIPCSSITDVRT
Site 55S325RLSIPCSSITDVRTT
Site 56T327SIPCSSITDVRTTTA
Site 57T331SSITDVRTTTALEMP
Site 58T332SITDVRTTTALEMPD
Site 59T333ITDVRTTTALEMPDR
Site 60T343EMPDRENTFVVKVEG
Site 61S376SDIQECLSPGPCPAT
Site 62T383SPGPCPATSPRPMTL
Site 63S384PGPCPATSPRPMTLP
Site 64T389ATSPRPMTLPLAPGT
Site 65S397LPLAPGTSFLTRENT
Site 66T404SFLTRENTDSLELSC
Site 67S406LTRENTDSLELSCLN
Site 68S410NTDSLELSCLNHSES
Site 69S415ELSCLNHSESLPSQD
Site 70S417SCLNHSESLPSQDLL
Site 71S420NHSESLPSQDLLLGP
Site 72S428QDLLLGPSESNDRLS
Site 73S430LLLGPSESNDRLSQG
Site 74S435SESNDRLSQGAYGGL
Site 75Y439 DRLSQGAYGGLSDRP
Site 76S443QGAYGGLSDRPSASI
Site 77S447GGLSDRPSASISPSS
Site 78S449LSDRPSASISPSSAS
Site 79S451DRPSASISPSSASIA
Site 80S454SASISPSSASIAASH
Site 81S456SISPSSASIAASHFD
Site 82S460SSASIAASHFDSMEL
Site 83S464IAASHFDSMELLPPE
Site 84T486EEGPPAGTVHPLSAP
Site 85S491AGTVHPLSAPYPPLD
Site 86Y494 VHPLSAPYPPLDTPE
Site 87T499APYPPLDTPETATGS
Site 88T502PPLDTPETATGSFLF
Site 89S506TPETATGSFLFQGEP
Site 90S523GEGDQPLSGYPWFHG
Site 91Y525GDQPLSGYPWFHGML
Site 92T543KAAQLVLTGGTGSHG
Site 93S557GVFLVRQSETRRGEY
Site 94Y564SETRRGEYVLTFNFQ
Site 95T567RRGEYVLTFNFQGKA
Site 96S580KAKHLRLSLNEEGQC
Site 97S623SSDVVLVSYVPSSQR
Site 98Y624SDVVLVSYVPSSQRQ
Site 99S627VLVSYVPSSQRQQEP
Site 100S628LVSYVPSSQRQQEPT
Site 101T635SQRQQEPTTSHDPPQ
Site 102S637RQQEPTTSHDPPQPP
Site 103S648PQPPEPPSWTDPPQP
Site 104T650PPEPPSWTDPPQPGA
Site 105S712EEAIAPGSEAQGAGS
Site 106S734PMVQLQQSPLGGDGE
Site 107Y753PRAINNQYSFV____
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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