PhosphoNET

           
Protein Info 
   
Short Name:  SPHK2
Full Name:  Sphingosine kinase 2
Alias:  EC 2.7.1.-; EC 2.7.1.91; SK 2; SPK 2
Type:  Lipid Metabolism - sphingolipid; EC 2.7.1.-; EC 2.7.1.91; Kinase, lipid
Mass (Da):  69217
Number AA:  654
UniProt ID:  Q9NRA0
International Prot ID:  IPI00215795
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829  GO:0005624   Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0017016  GO:0004143 PhosphoSite+ KinaseNET
Biological Process:  GO:0007205  GO:0006916  GO:0008283 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T20QRPDQELTGSWGHGP
Site 2S22PDQELTGSWGHGPRS
Site 3S29SWGHGPRSTLVRAKA
Site 4T30WGHGPRSTLVRAKAM
Site 5S47PPPPLAASTPLLHGE
Site 6S57LLHGEFGSYPARGPR
Site 7Y58LHGEFGSYPARGPRF
Site 8T68RGPRFALTLTSQALH
Site 9S71RFALTLTSQALHIQR
Site 10T102AEVSGCCTLRSRSPS
Site 11S105SGCCTLRSRSPSDSA
Site 12S107CCTLRSRSPSDSAAY
Site 13S109TLRSRSPSDSAAYFC
Site 14S111RSRSPSDSAAYFCIY
Site 15Y114SPSDSAAYFCIYTYP
Site 16Y118SAAYFCIYTYPRGRR
Site 17Y120AYFCIYTYPRGRRGA
Site 18T132RGARRRATRTFRADG
Site 19T134ARRRATRTFRADGAA
Site 20T173LPGDGEITPDLLPRP
Site 21T220LSFNLIQTERQNHAR
Site 22S234RELVQGLSLSEWDGI
Site 23S347VSDVDIQSERFRALG
Site 24S355ERFRALGSARFTLGT
Site 25T359ALGSARFTLGTVLGL
Site 26T371LGLATLHTYRGRLSY
Site 27Y372GLATLHTYRGRLSYL
Site 28S377HTYRGRLSYLPATVE
Site 29Y378TYRGRLSYLPATVEP
Site 30T382RLSYLPATVEPASPT
Site 31S387PATVEPASPTPAHSL
Site 32T389TVEPASPTPAHSLPR
Site 33S393ASPTPAHSLPRAKSE
Site 34S399HSLPRAKSELTLTPD
Site 35T402PRAKSELTLTPDPAP
Site 36T404AKSELTLTPDPAPPM
Site 37S414PAPPMAHSPLHRSVS
Site 38S419AHSPLHRSVSDLPLP
Site 39S421SPLHRSVSDLPLPLP
Site 40S434LPQPALASPGSPEPL
Site 41S445PEPLPILSLNGGGPE
Site 42S466GAGDAPLSPDPLLSS
Site 43S472LSPDPLLSSPPGSPK
Site 44S473SPDPLLSSPPGSPKA
Site 45S477LLSSPPGSPKAALHS
Site 46S484SPKAALHSPVSEGAP
Site 47T503SSGLPLPTPDARVGA
Site 48S511PDARVGASTCGPPDH
Site 49T512DARVGASTCGPPDHL
Site 50S594MERGSHFSLGCPQLG
Site 51T614AFRLEPLTPRGVLTV
Site 52T620LTPRGVLTVDGEQVE
Site 53Y628VDGEQVEYGPLQAQM
Site 54T641QMHPGIGTLLTGPPG
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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