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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MNK2
Full Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Alias:
EC 2.7.11.1; GPRK7; MKNK2
Type:
Protein-serine kinase, CAMK group, MAPKAPK family, MNK subfamily
Mass (Da):
51875
Number AA:
465
UniProt ID:
Q9HBH9
International Prot ID:
IPI00396114
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007166
GO:0006468
GO:0007243
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
L
Q
G
F
H
R
S
F
K
G
Q
N
P
F
Site 2
S27
N
P
F
E
L
A
F
S
L
D
Q
P
D
H
G
Site 3
S36
D
Q
P
D
H
G
D
S
D
F
G
L
Q
C
S
Site 4
S43
S
D
F
G
L
Q
C
S
A
R
P
D
M
P
A
Site 5
S51
A
R
P
D
M
P
A
S
Q
P
I
D
I
P
D
Site 6
T72
K
K
K
R
G
R
A
T
D
S
F
S
G
R
F
Site 7
S74
K
R
G
R
A
T
D
S
F
S
G
R
F
E
D
Site 8
S76
G
R
A
T
D
S
F
S
G
R
F
E
D
V
Y
Site 9
Y83
S
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
Site 10
S124
K
Q
P
G
H
I
R
S
R
V
F
R
E
V
E
Site 11
Y134
F
R
E
V
E
M
L
Y
Q
C
Q
G
H
R
N
Site 12
Y156
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
Site 13
S166
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
Site 14
S169
M
R
G
G
S
I
L
S
H
I
H
K
R
R
H
Site 15
S220
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
Site 16
S240
I
K
L
N
G
D
C
S
P
I
S
T
P
E
L
Site 17
S243
N
G
D
C
S
P
I
S
T
P
E
L
L
T
P
Site 18
T244
G
D
C
S
P
I
S
T
P
E
L
L
T
P
C
Site 19
T249
I
S
T
P
E
L
L
T
P
C
G
S
A
E
Y
Site 20
S253
E
L
L
T
P
C
G
S
A
E
Y
M
A
P
E
Site 21
Y256
T
P
C
G
S
A
E
Y
M
A
P
E
V
V
E
Site 22
S266
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
Site 23
S270
E
A
F
S
E
E
A
S
I
Y
D
K
R
C
D
Site 24
Y272
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
Site 25
S301
P
F
V
G
R
C
G
S
D
C
G
W
D
R
G
Site 26
Y327
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
Site 27
S358
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
Site 28
T379
A
P
E
N
T
L
P
T
P
M
V
L
Q
R
N
Site 29
S387
P
M
V
L
Q
R
N
S
C
A
K
D
L
T
S
Site 30
S437
T
S
R
C
L
Q
L
S
P
P
S
Q
S
K
L
Site 31
S440
C
L
Q
L
S
P
P
S
Q
S
K
L
A
Q
R
Site 32
S452
A
Q
R
R
Q
R
A
S
L
S
S
A
P
V
V
Site 33
S454
R
R
Q
R
A
S
L
S
S
A
P
V
V
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation