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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLK4
Full Name:
Dual specificity protein kinase CLK4
Alias:
EC 2.7.12.1
Type:
Protein-serine kinase, CMGC group, CLK family
Mass (Da):
57492
Number AA:
481
UniProt ID:
Q9HAZ1
International Prot ID:
IPI00180143
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
GO:0004713
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
P
D
W
D
S
R
E
S
W
G
H
E
S
Y
R
Site 2
S22
R
E
S
W
G
H
E
S
Y
R
G
S
H
K
R
Site 3
S26
G
H
E
S
Y
R
G
S
H
K
R
K
R
R
S
Site 4
S33
S
H
K
R
K
R
R
S
H
S
S
T
Q
E
N
Site 5
S35
K
R
K
R
R
S
H
S
S
T
Q
E
N
R
H
Site 6
S36
R
K
R
R
S
H
S
S
T
Q
E
N
R
H
C
Site 7
T37
K
R
R
S
H
S
S
T
Q
E
N
R
H
C
K
Site 8
Y56
F
K
E
S
D
C
H
Y
L
E
A
R
S
L
N
Site 9
S61
C
H
Y
L
E
A
R
S
L
N
E
R
D
Y
R
Site 10
Y67
R
S
L
N
E
R
D
Y
R
D
R
R
Y
V
D
Site 11
Y72
R
D
Y
R
D
R
R
Y
V
D
E
Y
R
N
D
Site 12
Y76
D
R
R
Y
V
D
E
Y
R
N
D
Y
C
E
G
Site 13
Y80
V
D
E
Y
R
N
D
Y
C
E
G
Y
V
P
R
Site 14
Y84
R
N
D
Y
C
E
G
Y
V
P
R
H
Y
H
R
Site 15
Y89
E
G
Y
V
P
R
H
Y
H
R
D
I
E
S
G
Site 16
S102
S
G
Y
R
I
H
C
S
K
S
S
V
R
S
R
Site 17
S104
Y
R
I
H
C
S
K
S
S
V
R
S
R
R
S
Site 18
S105
R
I
H
C
S
K
S
S
V
R
S
R
R
S
S
Site 19
S108
C
S
K
S
S
V
R
S
R
R
S
S
P
K
R
Site 20
S111
S
S
V
R
S
R
R
S
S
P
K
R
K
R
N
Site 21
S112
S
V
R
S
R
R
S
S
P
K
R
K
R
N
R
Site 22
S122
R
K
R
N
R
H
C
S
S
H
Q
S
R
S
K
Site 23
S123
K
R
N
R
H
C
S
S
H
Q
S
R
S
K
S
Site 24
S126
R
H
C
S
S
H
Q
S
R
S
K
S
H
R
R
Site 25
S128
C
S
S
H
Q
S
R
S
K
S
H
R
R
K
R
Site 26
S130
S
H
Q
S
R
S
K
S
H
R
R
K
R
S
R
Site 27
S136
K
S
H
R
R
K
R
S
R
S
I
E
D
D
E
Site 28
S138
H
R
R
K
R
S
R
S
I
E
D
D
E
E
G
Site 29
Y159
G
D
V
L
R
A
R
Y
E
I
V
D
T
L
G
Site 30
S203
R
Y
R
E
A
A
R
S
E
I
Q
V
L
E
H
Site 31
S213
Q
V
L
E
H
L
N
S
T
D
P
N
S
V
F
Site 32
T214
V
L
E
H
L
N
S
T
D
P
N
S
V
F
R
Site 33
Y247
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
S
Site 34
Y299
I
L
F
V
K
S
D
Y
V
V
K
Y
N
S
K
Site 35
Y303
K
S
D
Y
V
V
K
Y
N
S
K
M
K
R
D
Site 36
T313
K
M
K
R
D
E
R
T
L
K
N
T
D
I
K
Site 37
T317
D
E
R
T
L
K
N
T
D
I
K
V
V
D
F
Site 38
S326
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
Site 39
T328
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
Site 40
Y329
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
Site 41
S335
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Site 42
T336
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
Site 43
S339
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
Site 44
T340
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
Site 45
Y343
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
Site 46
T404
P
Q
H
M
I
Q
K
T
R
K
R
K
Y
F
H
Site 47
Y409
Q
K
T
R
K
R
K
Y
F
H
H
N
Q
L
D
Site 48
Y426
E
H
S
S
A
G
R
Y
V
R
R
R
C
K
P
Site 49
Y458
L
V
R
R
M
L
E
Y
D
P
T
Q
R
I
T
Site 50
T461
R
M
L
E
Y
D
P
T
Q
R
I
T
L
D
E
Site 51
T465
Y
D
P
T
Q
R
I
T
L
D
E
A
L
Q
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation